Biomagnetic activity in prostate cancer and BPH.

OBJECTIVE The aim of this study was to investigate the role of biomagnetic activity measurements in detecting prostate malignancies, in differentiating cancerous from benign prostate lesions and in generally improving our understanding of prostate cancer biology. METHODS Magnetic recordings were obtained from 47 patients with palpable prostate lesions. Twenty-four had prostate carcinoma and 23 benign prostatic hyperplasia (BPH). RESULTS The magnetic field recorded in the 2-7 Hz frequency range was of high amplitude in most (95%) malignant lesions 248 +/- 82 Ft/Hz) and of low amplitude in most (95%) benign ones (166 +/-31 Ft/Hz). These findings displayed significant difference (p = 0.0021). CONCLUSIONS Prostate cancer emits higher biomagnetic activity than BPH. This finding confirms the higher angiogenic activity of prostate cancer. The use of this method is safe and seems promising.

[1]  G. Botchkina,et al.  Noninvasive Detection of Prostate Cancer by Quantitative Analysis of Telomerase Activity , 2005, Clinical Cancer Research.

[2]  J. McGary Theoretical foundation for real‐time prostate localization using an inductively coupled transmitter and a superconducting quantum interference device (SQUID) magnetometer system , 2004, Journal of applied clinical medical physics.

[3]  M. Stöckle,et al.  Artificial neural network analysis (ANNA) of prostatic transrectal ultrasound , 1999, The Prostate.

[4]  J. Overgaard,et al.  Microvessel density predicts survival in prostate cancer patients subjected to watchful waiting. , 1998, British Journal of Cancer.

[5]  P. Anninos,et al.  Biomagnetic activity in ovarian lesions. , 1998, Anticancer research.

[6]  P Anninos,et al.  The hemodynamics of the umbilical artery in normal and pre-eclamptic pregnancies. A new application of SQUID biomagnetometry , 1997, Journal of perinatal medicine.

[7]  Fetal magnetoencephalographic mapping in normal and pre-eclamptic pregnancies. , 1997, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[8]  P. A. Anninos,et al.  Biomagnetic activity in breast lesions , 1994 .

[9]  W Blumenfeld,et al.  Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. , 1993, The American journal of pathology.

[10]  M. Klagsbrun,et al.  Regulators of angiogenesis. , 1991, Annual review of physiology.

[11]  J. Folkman,et al.  ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS , 1971, The Journal of experimental medicine.