Personality, Dopamine Receptor D4 Exon III Polymorphisms, and Academic Achievement in Medical Students

This study investigated the relationships between genetic polymorphisms, personality traits, and academic achievement in medical school students. Study subjects were 220 1st-year medical students at Korea University Medical School during two consecutive academic years (2003–2004). Grade-point averages (GPA) during the second semester of the 1st year of the medical school were obtained as a measure of academic achievement. In addition, all participants completed the Temperament and Character Inventory and questionnaires on depression and anxiety. The polymorphisms in exon III of the dopamine D4 receptor (DRD4) were determined using the polymerase chain reaction. Our results revealed that both male and female subjects with a higher GPA may be characterized as having higher persistence and lower novelty seeking traits. In addition, male subjects with high GPA had higher scores in self directedness and female subjects with a higher GPA may be characterized as having higher scores in harm avoidance. Male students with 4-repeat alleles had a significantly lower GPA than male students without 4-repeat alleles.This relationship also remained after controlling for the personality variables, none of which showed a relationship with the polymorphism after Bonferroni correction. For females, however, no associations could be found between GPA and the polymorphism. Thus, the present study demonstrated for the first time a possible influence of the DRD4 48 bp variable number of tandem repeats polymorphism on academic achievement and proved that this was not mediated by performance-associated personality traits.

[1]  B. Ham,et al.  Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population , 2005, Psychiatric genetics.

[2]  M. Schmidt,et al.  The dopamine D4 receptor gene exon III polymorphism is associated with novelty seeking in 15-year-old males from a high-risk community sample , 2005, Journal of Neural Transmission.

[3]  J. Wilding,et al.  The relation of depression and anxiety to life-stress and achievement in students. , 2004, British journal of psychology.

[4]  J. Swanson,et al.  The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. , 2004, American journal of human genetics.

[5]  Seung-hyun Kim,et al.  Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[6]  Filip Lievens,et al.  Medical students' personality characteristics and academic performance: a five‐factor model perspective , 2002, Medical education.

[7]  C. Robert Cloninger,et al.  Temperament, character, and personality disorders: etiologic, diagnostic, treatment issues , 2002, Acta psychiatrica Scandinavica.

[8]  In Kyoon Lyoo,et al.  Reliability and validity of the Korean version of the Temperament and Character Inventory. , 2002, Comprehensive psychiatry.

[9]  Y. Fukumaki,et al.  Novel polymorphisms in the upstream region of the human dopamine D4 receptor (DRD4) gene , 1999, Journal of Human Genetics.

[10]  M. Jarvelin,et al.  Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. , 1999, The American journal of psychiatry.

[11]  T. Belin,et al.  D2 and D4 dopamine receptor polymorphisms and personality. , 1998, American journal of medical genetics.

[12]  S. Kanba,et al.  Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. , 1997, American journal of medical genetics.

[13]  J. Koz̆ený,et al.  Predicting academic performance of medical students: the first three years. , 1997, The American journal of psychiatry.

[14]  Diane Musgrave-Marquart,et al.  Personality, academic attribution, and substance use as predictors of academic achievement in college students. , 1997 .

[15]  R. Ebstein,et al.  5-HT2C (HTR2C) serotonin receptor gene polymorphism associated with the human personality trait of reward dependence: interaction with dopamine D4 receptor (D4DR) and dopamine D3 receptor (D3DR) polymorphisms. , 1997, American journal of medical genetics.

[16]  Ivan Mervielde,et al.  Personality and interests as predictors of educational streaming and achievement , 1996 .

[17]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[18]  M Linnoila,et al.  The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. , 1996, Molecular psychiatry.

[19]  K. Herman,et al.  Depression and academic impairment in college students. , 1996, Journal of American college health : J of ACH.

[20]  H. V. Van Tol,et al.  Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants , 1995, Journal of neurochemistry.

[21]  C. R. Cloninger,et al.  A psychobiological model of temperament and character. , 1993, Archives of general psychiatry.

[22]  K K Kidd,et al.  A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. , 1993, Human molecular genetics.

[23]  S. Dollinger,et al.  Personality and performance in "personality": Conscientiousness and openness. , 1991 .

[24]  Philip Seeman,et al.  Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine , 1991, Nature.

[25]  R. McCrae.  Creativity, divergent thinking, and openness to experience. , 1987 .

[26]  Y. Fukumaki,et al.  Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits , 2001, Journal of Human Genetics.

[27]  T. Arinami,et al.  Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait , 2000, Molecular Psychiatry.

[28]  P. Sullivan,et al.  No association between novelty seeking and the type 4 dopamine receptor gene (DRD4) in two New Zealand samples. , 1998, The American journal of psychiatry.

[29]  C. Robert Cloninger,et al.  Genetic and environmental structure of the Tridimensional Personality Questionnaire: three or four temperament dimensions? , 1996, Journal of personality and social psychology.

[30]  R. Ebstein,et al.  Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking , 1996, Nature Genetics.

[31]  Dw Hahn,et al.  Korean adaptation of Spielberger's STAI (K-STAI) , 1996 .

[32]  D. Murphy,et al.  Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking , 1996, Nature Genetics.

[33]  R. R. Abidin.  Psychological Assessment Resources , 1995 .

[34]  Judith L. Johnson,et al.  Personality and chronic procrastination by university students during an academic examination period , 1991 .

[35]  James McKenzie.  Neuroticism and academic achievement: the furneaux factor , 1989 .

[36]  Hm Hahn,et al.  A Standardization study of Beck Depression Inventory in Korea , 1982 .

[37]  E. Ferguson,et al.  Learning in practice Factors associated with success in medical school: systematic review of the literature , 2022 .