A Fluid-Cell Interaction and Adhesion Algorithm for Tissue Coating of Cardiovascular Implants

In this manuscript we develop a fluid-cell interaction and adhesion algorithm applied to modeling the cell coating of artificial surfaces of cardiovascular implants for improved biocompatibility. The fluid-cell interaction and adhesion algorithm proposed in this manuscript is a multiscale model that captures the process of cell adhesion which occurs at a scale of a few nanometers and couples it with fluid-cell interaction which occurs at a scale of a few hundred microns. Cells are assumed rigid and neutrally buoyant. Cell adhesion is modeled using a kinetics-based dynamic adhesion algorithm. Fluid-cell interaction is modeled using the fictitious domain method with distributed Lagrange multipliers. The coupling between the two is achieved through a time-splitting scheme. Novel results regarding the influence of certain fluid dynamic parameters and adhesion parameters on the generation of a stable and strong tissue coating of artificial surfaces are presented. The modular nature of this algorithm makes it e...

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