Simple Method for Evaluation of Planum Temporale Pyramidal Neurons Shrinkage in Postmortem Tissue of Alzheimer Disease Patients

We measured the length of the pyramidal neurons in the cortical layer III in four subregions of the planum temporale (transitions into superior temporal gyrus, Heschl's gyrus, insular cortex, and Sylvian fissure) in control group and Alzheimer disease patients. Our hypothesis was that overall length of the pyramidal neurons would be smaller in the Alzheimer disease group compared to controls and also there would be right-left asymmetry in both the control and Alzheimer disease groups. We found pyramidal neuron length asymmetry only in controls—in the transition into the Sylvian fissure—and the rest of the subregions in the control group and Alzheimer disease patients did not show size difference. However, control-Alzheimer disease group pyramidal neuron length comparison revealed (a) no length difference in superior temporal gyrus transition area, (b) reversal of asymmetry in the insular transition area with left insular transition significantly shorter in the Alzheimer disease group compared to the control group, (c) both right and left Heschl's gyrus transitions significantly shorter in the Alzheimer disease group compared to the control group, and (d) right Sylvian fissure transition significantly shorter in the Alzheimer disease group compared to the control group. This neuronal length measurement method could supplement already existing neuropathological criteria for postmortem Alzheimer disease diagnostics.

[1]  Iiro P. Jääskeläinen,et al.  Psychophysics and neuronal bases of sound localization in humans , 2014, Hearing Research.

[2]  T. Crow,et al.  Minicolumn thinning in temporal lobe association cortex but not primary auditory cortex in normal human ageing , 2006, Acta Neuropathologica.

[3]  J. Hutsler.  The specialized structure of human language cortex: Pyramidal cell size asymmetries within auditory and language-associated regions of the temporal lobes , 2003, Brain and Language.

[4]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[5]  David A Lewis,et al.  Reduced Pyramidal Cell Somal Volume in Auditory Association Cortex of Subjects with Schizophrenia , 2003, Neuropsychopharmacology.

[6]  S. Chance,et al.  Microanatomical correlates of cognitive ability and decline: normal ageing, MCI, and Alzheimer's disease. , 2011, Cerebral cortex.

[7]  M. West.  Tissue shrinkage and stereological studies. , 2013, Cold Spring Harbor Protocols.

[8]  Sabine Landau,et al.  Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders , 2005, Schizophrenia Research.

[9]  G. G. Stokes.  "J." , 1890, The New Yale Book of Quotations.

[10]  H J Gundersen,et al.  The nucleator , 1988, Journal of microscopy.

[11]  D. Řípová,et al.  Volumetric Analysis of the Pons, Cerebellum and Hippocampi in Patients with Alzheimer’s Disease , 2012, Dementia and Geriatric Cognitive Disorders.

[12]  A. David,et al.  The planum temporale: a systematic, quantitative review of its structural, functional and clinical significance , 1999, Brain Research Reviews.

[13]  D. Javitt,et al.  Altered volume and hemispheric asymmetry of the superficial cortical layers in the schizophrenia planum temporale , 2009, The European journal of neuroscience.

[14]  Gregory Hickok,et al.  Redefining the Functional Organization of the Planum Temporale Region: Space, Objects, and Sensory–Motor Integration , 2012 .

[15]  D. Poeppel,et al.  The Human Auditory Cortex , 2012, Springer Handbook of Auditory Research.

[16]  Grey Giddins.  Statistics , 2016, The Journal of hand surgery, European volume.

[17]  J. Tilak Ratnanather,et al.  Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder , 2013, Schizophrenia Research.

[18]  F. Španiel,et al.  Planum temporale analysis via a new volumetric method in autoptic brains of demented and psychotic patients. , 2009, Current Alzheimer research.