Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom.

The occurrence of 12 selected pharmaceutical compounds and pharmaceutical compound metabolites in sewage treatment works (STW) effluents and surface waters was investigated. The substances selected for the monitoring programme were identified by a risk ranking procedure to identify those substances with the greatest potential to pose a risk to the aquatic environment. STW final effluent and surface water samples were collected from Corby, Great Billing, East Hyde, Harpenden and Ryemeads STWs. Ten of the 12 pharmaceutical compounds were detected in the STW effluent samples: propranolol (100%, median = 76 ng/l), diclofenac (86%, median = 424 ng/l), ibuprofen (84%, median = 3086 ng/l), mefenamic acid (81%, median = 133 ng/l), dextropropoxyphene (74%, median = 195 ng/l), trimethoprim (65%, 70 ng/l), erythromycin (44%, < 10 ng/l), acetyl-sulfamethoxazole (33%, median =< 50 ng/l), sulfamethoxazole (9%, median =< 50 ng/l), tamoxifen (4%, median =< 10 ng/l). In the corresponding receiving streams, fewer compounds and lower concentrations were found: propranolol (87%, median = 29 ng/l), ibuprofen (69%, median = 826 ng/l), mefenamic acid (60%, median = 62 ng/l), dextropropoxyphene (53%, median = 58 ng/l), diclofenac (47%, median =< 20 ng/l), erythromycin (38%, median =< 10 ng/l), trimethoprim (38%, median =< 10 ng/l), acetyl sulfamethoxazole (38%, median =< 50 ng/l). Four human pharmaceutical compounds were detected in samples upstream of the STWs sampled: ibuprofen (57%, median = 181 ng/l), trimethoprim (36%, median < 10 ng/l), erythromycin (17%, median =< 10 ng/l), propranolol (14%, median =< 10 ng/l), suggesting that longer range stream transport of some compounds is possible. The particular STW that was sampled and the month that it was sampled significantly influenced the measured concentrations of several, but not all, substances. There was no significant relationship between usage data and the overall frequency with which different substances were detected. There was however, some evidence to suggest that usage data are positively associated with concentrations of pharmaceuticals in effluent and, particularly, with concentrations measured in surface waters below STWs. These results suggest that most sewage treatment works in England and Wales are likely to be routinely discharging small quantities of pharmaceuticals into UK rivers. None of the pharmaceuticals were found at concentrations that were high enough to cause acute toxic impacts to aquatic organisms. However, insufficient data were available to be able to comment on whether the concentrations measured have the potential to result in more subtle long-term effects on aquatic organisms (e.g. effects on growth, ability to reproduce).

[1]  T. Ternes,et al.  Pharmaceuticals and personal care products in the environment: agents of subtle change? , 1999, Environmental health perspectives.

[2]  M. Slattery,et al.  Waterborne and sediment toxicity of fluoxetine to select organisms. , 2003, Chemosphere.

[3]  T. Poiger,et al.  Occurrence and Fate of the Pharmaceutical Drug Diclofenac in Surface Waters: Rapid Photodegradation in a Lake , 1998 .

[4]  M. C. Newman,et al.  Quantitative methods in aquatic ecotoxicology , 1995 .

[5]  T. Heberer,et al.  Occurrence and Distribution of Organic Contaminants in the Aquatic System in Berlin. Part I: Drug Residues and other Polar Contaminants in Berlin Surface and Groundwater , 1998 .

[6]  T. Ternes Occurrence of drugs in German sewage treatment plants and rivers 1 Dedicated to Professor Dr. Klaus , 1998 .

[7]  M. Waldock,et al.  Contaminants in seawater around England and Wales: results from monitoring surveys, 1990-1992 , 1994 .

[8]  T. Ternes,et al.  Behaviour and occurrence of estrogens in municipal sewage treatment plants--II. Aerobic batch experiments with activated sludge. , 1999, The Science of the total environment.

[9]  H. Singer,et al.  Simultaneous quantification of neutral and acidic pharmaceuticals and pesticides at the low-ng/l level in surface and waste water. , 2001, Journal of chromatography. A.

[10]  K. Kümmerer Pharmaceuticals in the Environment , 2001 .

[11]  T. Heberer,et al.  Pharmaceuticals in the aquatic environment , 1997 .

[12]  C. Müller,et al.  Do pharmaceuticals affect freshwater invertebrates? A study with the cnidarian Hydra vulgaris. , 2003, Chemosphere.

[13]  E. Thurman,et al.  Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. , 2002 .

[14]  M L Richardson,et al.  The fate of pharmaceutical chemicals in the aquatic environment , 1985, The Journal of pharmacy and pharmacology.

[15]  W. Buchberger,et al.  Determination of drug residues in water by the combination of liquid chromatography or capillary electrophoresis with electrospray mass spectrometry. , 2001, Journal of chromatography. A.

[16]  Martin Kampmann,et al.  Ozonation: a tool for removal of pharmaceuticals, contrast media and musk fragrances from wastewater? , 2003, Water research.

[17]  T. Poiger,et al.  Occurrence and Environmental Behavior of the Chiral Pharmaceutical Drug Ibuprofen in Surface Waters and in Wastewater , 1999 .

[18]  Oliver A.H. Jones,et al.  Aquatic environmental assessment of the top 25 English prescription pharmaceuticals. , 2002, Water research.

[19]  S. Jørgensen,et al.  Occurrence, fate and effects of pharmaceutical substances in the environment--a review. , 1998, Chemosphere.

[20]  D. Barceló,et al.  Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. , 2001, Journal of chromatography. A.

[21]  Christian G. Daughton,et al.  Pharmaceuticals and Personal Care Products in the Environment: Overarching Issues and Overview , 2001 .

[22]  Richard J. Williams,et al.  Steroid estrogens profiles along river stretches arising from sewage treatment works discharges. , 2003, Environmental science & technology.

[23]  R Hirsch,et al.  Occurrence of antibiotics in the aquatic environment. , 1999, The Science of the total environment.

[24]  R. Wakeman,et al.  Consumption and Environmental Hazards of Pharmaceutical Substances in the UK , 2003 .

[25]  T. Ternes,et al.  Determination of antibiotics in different water compartments via liquid chromatography-electrospray tandem mass spectrometry. , 1998, Journal of chromatography. A.

[26]  T. Ternes,et al.  Polar drug residues in sewage and natural waters in the state of Rio de Janeiro, Brazil. , 1999, The Science of the total environment.

[27]  T. Ternes,et al.  Nachweis von Betablockern und Bronchospasmolytika in der aquatischen Umwelt , 1996 .

[28]  K. Thomas,et al.  Determination of selected human pharmaceutical compounds in effluent and surface water samples by high-performance liquid chromatography-electrospray tandem mass spectrometry. , 2003, Journal of chromatography. A.