Resonance Raman based skin carotenoid measurements in newborns and infants

We describe Resonance Raman based skin carotenoid measurements in newborns and infants. Skin- and serum carotenoid levels correlate with high statistical significance in healthy newborns and infants, and with reduced accuracy also in prematurely born infants, who in general feature very low carotenoid levels and thin transparent skin giving rise to large background absorption effects. Skin carotenoid levels can be easily compared among subjects and/or tracked in longitudinal studies with the highly molecule-specific Raman method. It therefore holds promise as a rapid, non-invasive, carotenoid antioxidant assessment method for newborns and infants in the field of pediatrics.

[1]  O. Sommerburg,et al.  Carotenoid supply in breast-fed and formula-fed neonates , 2000, European Journal of Pediatrics.

[2]  F. Ferris,et al.  The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No. 22. , 2007, Archives of ophthalmology.

[3]  F. Khachik,et al.  Non-invasive raman spectroscopic detection of carotenoids in human skin. , 2000, The Journal of investigative dermatology.

[4]  Haiqun Lin,et al.  Skin carotenoid status measured by resonance Raman spectroscopy as a biomarker of fruit and vegetable intake in preschool children , 2012, European Journal of Clinical Nutrition.

[5]  D. Thurnham,et al.  Nutritional factors and visual function in premature infants , 2001, Proceedings of the Nutrition Society.

[6]  Werner Gellermann,et al.  In vivo resonant Raman measurement of macular carotenoid pigments in the young and the aging human retina. , 2002, Journal of the Optical Society of America. A, Optics, image science, and vision.

[7]  A. N. Bashkatov,et al.  Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm , 2005 .

[8]  P. Auld,et al.  Skin Reflectance in the Newborn Infant , 1976, Pediatric Research.

[9]  E. Rimm,et al.  Intake of specific carotenoids and risk of lung cancer in 2 prospective US cohorts. , 2000, The American journal of clinical nutrition.

[10]  G A Colditz,et al.  Intake of carotenoids and retinol in relation to risk of prostate cancer. , 1995, Journal of the National Cancer Institute.

[11]  M. Barzilai,et al.  Isocratic non-aqueous reversed-phase high-performance liquid chromatographic separation of capsanthin and capsorubin in red peppers (Capsicum annuum L.), paprika and oleoresin. , 1997, Journal of chromatography. A.

[12]  J. Buring,et al.  Associations of plasma carotenoids with risk factors and biomarkers related to cardiovascular disease in middle-aged and older women. , 2008, The American journal of clinical nutrition.

[13]  I. Ermakov,et al.  Validation model for Raman based skin carotenoid detection. , 2010, Archives of biochemistry and biophysics.

[14]  R. Parker.  Analysis of carotenoids in human plasma and tissues. , 1993, Methods in enzymology.

[15]  Werner Gellermann,et al.  Resonance Raman imaging of macular pigment distributions in the human retina. , 2008, Journal of the Optical Society of America. A, Optics, image science, and vision.

[16]  E. Ostrea,et al.  Influence of breast-feeding on the restoration of the low serum concentration of vitamin E and beta-carotene in the newborn infant. , 1986, American journal of obstetrics and gynecology.

[17]  S. Mayne,et al.  Carotenoids in Health and Disease , 2004 .

[18]  P. Bernstein,et al.  Resonance Raman Spectroscopy and the Preterm Infant Carotenoid Status , 2013, Journal of pediatric gastroenterology and nutrition.

[19]  U. Blume-Peytavi,et al.  Stratum Corneum Maturation , 2004, Skin Pharmacology and Physiology.

[20]  L. Ferrucci,et al.  Low serum selenium and total carotenoids predict mortality among older women living in the community: the women's health and aging studies. , 2006, The Journal of nutrition.

[21]  Werner Gellermann,et al.  Simple Raman Instrument for in vivo Detection of Macular Pigments , 2005, Applied spectroscopy.

[22]  Werner Gellermann,et al.  Dermal carotenoid measurements via pressure mediated reflection spectroscopy , 2012, Journal of biophotonics.

[23]  I. Ermakov,et al.  Resonance Raman detection of carotenoid antioxidants in living human tissues. , 2001, Optics letters.

[24]  C. Holman,et al.  Intake of specific carotenoids and the risk of epithelial ovarian cancer , 2007, British Journal of Nutrition.

[25]  Werner Gellermann,et al.  Noninvasive assessment of dermal carotenoids as a biomarker of fruit and vegetable intake. , 2010, The American journal of clinical nutrition.

[26]  D. Thibeault.  THE PRECARIOUS ANTIOXIDANT DEFENSES OF THE PRETERM INFANT , 2000, American journal of perinatology.

[27]  L. P. Zhao,et al.  Intake of specific carotenoids and lung cancer risk. , 1993, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[28]  T. Nurmi,et al.  Simultaneous measurement of retinol, alpha-tocopherol and six carotenoids in human plasma by using an isocratic reversed-phase HPLC method. , 2008, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[29]  C. Rock,et al.  Plasma carotenoid levels in human subjects fed a low carotenoid diet. , 1992, The Journal of nutrition.