Blunt-head trauma associated with widespread water-diffusion changes

of Microbiology at the All India Institute of Medical Sciences, New Delhi, was carried out. 5 mL of blood in 50 mL of brain h e a rt infusion (BHI) broth was received in the laborat o ry for culture from patients clinically suspected of enteric fever and processed by standard bacteri o l o gical techniques. Antimicrobial susceptibility was done by Stokes method as d e s c ribed by the Working Pa rty on Antibiotic Sensitivity Testing of the British Society for A n t i m i c r o b i a l C h e m o t h e r a p y. Whereas isolates remained sensitive to c i p r o f l oxacin and ceftri a x o n e , there has been a significant increase in the sensitivity of S typhi to chloramphenicol and a m oxycillin over the ye a rs (table). Our study shows that 91·6% strains of S typhi were sensitive to chloramphenicol in 1998 as compared with 71·9% in 1994. The resurgence of chloramphenicol-sensitive S typhi m ay have been because of restricted usage of this drug in the community for the treatment of typhoid. It appears that chloramphenicol m ay re-emerge as the drug of choice. It is cheaper than thirdg e n e r ation cephalosporins and its clinical efficacy is already well established.