Cell‐Specific Imd‐NF‐&kgr;B Responses Enable Simultaneous Antibacterial Immunity and Intestinal Epithelial Cell Shedding upon Bacterial Infection

[1]  João H. F. Pedra,et al.  p47 licenses activation of the immune deficiency pathway in the tick Ixodes scapularis , 2018, Proceedings of the National Academy of Sciences.

[2]  B. Lemaître,et al.  Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster , 2018, Genetics.

[3]  Yulong Yin,et al.  Beyond immunity: The Imd pathway as a coordinator of host defense, organismal physiology and behavior. , 2017, Developmental and comparative immunology.

[4]  A. Watson,et al.  Deciphering the Complex Signaling Systems That Regulate Intestinal Epithelial Cell Death Processes and Shedding , 2017, Front. Immunol..

[5]  L. E. O’Brien,et al.  Feedback regulation of steady-state epithelial turnover and organ size , 2017, Nature.

[6]  B. Lemaître,et al.  A genetic framework controlling the differentiation of intestinal stem cells during regeneration in Drosophila , 2017, PLoS genetics.

[7]  I. Brodsky,et al.  NAIP‐NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL‐18 Release via Activation of Caspase‐1 and ‐8 , 2017, Immunity.

[8]  I. Kounatidis,et al.  Interaction Between Familial Transmission and a Constitutively Active Immune System Shapes Gut Microbiota in Drosophila melanogaster , 2017, Genetics.

[9]  B. Edgar,et al.  ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration , 2017, Nature Communications.

[10]  M. Soares,et al.  Disease tolerance and immunity in host protection against infection , 2017, Nature Reviews Immunology.

[11]  D. Walker,et al.  Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis , 2016, Nature Cell Biology.

[12]  F. Dalle,et al.  Enterocyte Purge and Rapid Recovery Is a Resilience Reaction of the Gut Epithelium to Pore-Forming Toxin Attack. , 2016, Cell host & microbe.

[13]  Elena M. Lucchetta,et al.  Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. , 2016, Current opinion in genetics & development.

[14]  B. Lemaître,et al.  Accumulation of differentiating intestinal stem cell progenies drives tumorigenesis , 2015, Nature Communications.

[15]  W. Hardt,et al.  Inflammasomes of the intestinal epithelium. , 2015, Trends in immunology.

[16]  B. Edgar,et al.  Niche Appropriation by Drosophila Intestinal Stem Cell Tumors , 2015, Nature Cell Biology.

[17]  Y. Tsujimoto,et al.  Role of RIP1 in physiological enterocyte turnover in mouse small intestine via nonapoptotic death , 2015, Genes to cells : devoted to molecular & cellular mechanisms.

[18]  L. Johnston,et al.  An ancient defense system eliminates unfit cells from developing tissues during cell competition , 2014, Science.

[19]  S. Cherry,et al.  Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology , 2014, Nature Reviews Immunology.

[20]  W. Hardt,et al.  Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. , 2014, Cell host & microbe.

[21]  B. Lemaître,et al.  Methods to study Drosophila immunity. , 2014, Methods.

[22]  E. Fuchs,et al.  Plasticity of epithelial stem cells in tissue regeneration , 2014, Science.

[23]  Nichole A. Broderick,et al.  Microbiota-Induced Changes in Drosophila melanogaster Host Gene Expression and Gut Morphology , 2014, mBio.

[24]  D. Puthier,et al.  Drosophila Microbiota Modulates Host Metabolic Gene Expression via IMD/NF-κB Signaling , 2014, PloS one.

[25]  N. Barker Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration , 2013, Nature Reviews Molecular Cell Biology.

[26]  B. Edgar,et al.  RNA expression profiling from FACS-isolated cells of the Drosophila intestine. , 2013, Current protocols in stem cell biology.

[27]  A. Spradling,et al.  Physiological and stem cell compartmentalization within the Drosophila midgut , 2013, eLife.

[28]  R. Sutton,et al.  A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide , 2013, Disease Models & Mechanisms.

[29]  Nichole A. Broderick,et al.  Gut homeostasis in a microbial world: insights from Drosophila melanogaster , 2013, Nature Reviews Microbiology.

[30]  Hsiao Yu Fang,et al.  Morphological and molecular characterization of adult midgut compartmentalization in Drosophila. , 2013, Cell reports.

[31]  J. Ryu,et al.  Bacterial-Derived Uracil as a Modulator of Mucosal Immunity and Gut-Microbe Homeostasis in Drosophila , 2013, Cell.

[32]  B. Charroux,et al.  Peptidoglycan sensing by the receptor PGRP-LE in the Drosophila gut induces immune responses to infectious bacteria and tolerance to microbiota. , 2012, Cell host & microbe.

[33]  B. Lemaître,et al.  Tissue- and Ligand-Specific Sensing of Gram-Negative Infection in Drosophila by PGRP-LC Isoforms and PGRP-LE , 2012, The Journal of Immunology.

[34]  B. Edgar,et al.  Intestinal stem cell function in Drosophila and mice. , 2012, Current opinion in genetics & development.

[35]  Johannes E. Schindelin,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[36]  H. Horvitz,et al.  Programmed elimination of cells by caspase-independent cell extrusion in C. elegans , 2012, Nature.

[37]  D. Wassarman,et al.  ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila , 2012, Proceedings of the National Academy of Sciences.

[38]  B. Lemaître,et al.  Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection. , 2011, Immunity.

[39]  Rudi Beyaert,et al.  Enterocyte death and intestinal barrier maintenance in homeostasis and disease. , 2011, Trends in molecular medicine.

[40]  A. Watson,et al.  The epithelial barrier is maintained by in vivo tight junction expansion during pathologic intestinal epithelial shedding. , 2011, Gastroenterology.

[41]  B. Edgar,et al.  EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. , 2011, Cell stem cell.

[42]  B. Lemaître,et al.  Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection , 2010, BMC Biology.

[43]  J. Celli,et al.  Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia , 2010, Proceedings of the National Academy of Sciences.

[44]  Maria T. Abreu,et al.  Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function , 2010, Nature Reviews Immunology.

[45]  M. Birnbaum,et al.  The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling , 2009, Proceedings of the National Academy of Sciences.

[46]  Nichole A. Broderick,et al.  Invasive and indigenous microbiota impact intestinal stem cell activity through multiple pathways in Drosophila. , 2009, Genes & development.

[47]  B. Edgar,et al.  Cytokine/Jak/Stat Signaling Mediates Regeneration and Homeostasis in the Drosophila Midgut , 2009, Cell.

[48]  Sylvain Pradervand,et al.  Drosophila intestinal response to bacterial infection: activation of host defense and stem cell proliferation. , 2009, Cell host & microbe.

[49]  Y. Ip,et al.  Tissue damage-induced intestinal stem cell division in Drosophila. , 2009, Cell stem cell.

[50]  Heinrich Jasper,et al.  JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. , 2008, Cell stem cell.

[51]  G. Rubin,et al.  Tools for neuroanatomy and neurogenetics in Drosophila , 2008, Proceedings of the National Academy of Sciences.

[52]  J. Ryu,et al.  Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila , 2008, Science.

[53]  William C Earnshaw,et al.  Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis. , 2007, Experimental cell research.

[54]  D. Bohmann,et al.  JNK‐ and Fos‐regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila , 2006, The EMBO journal.

[55]  B. Lemaître,et al.  Prevalence of Local Immune Response against Oral Infection in a Drosophila/Pseudomonas Infection Model , 2006, PLoS pathogens.

[56]  N. Perrimon,et al.  Evidence that stem cells reside in the adult Drosophila midgut epithelium , 2006, Nature.

[57]  A. Garcı́a-Bellido,et al.  Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade. , 2004, Developmental cell.

[58]  Ronald L. Davis,et al.  Spatiotemporal Gene Expression Targeting with the TARGET and Gene-Switch Systems in Drosophila , 2004, Science's STKE.

[59]  T. Maniatis,et al.  Immune Activation of NF-κB and JNK Requires Drosophila TAK1* , 2003, Journal of Biological Chemistry.

[60]  B. Lemaître,et al.  Inducible Expression of Double-Stranded RNA Reveals a Role for dFADD in the Regulation of the Antibacterial Response in Drosophila Adults , 2002, Current Biology.

[61]  D. Zachary,et al.  Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. , 2001, Developmental cell.

[62]  B. Lemaître,et al.  Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-kappaB-dependent innate immune responses. , 2001, Genes & development.

[63]  B. Lemaître,et al.  The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[64]  C. Coopersmith,et al.  Bcl-2 inhibits ischemia-reperfusion-induced apoptosis in the intestinal epithelium of transgenic mice. , 1999, American journal of physiology. Gastrointestinal and liver physiology.

[65]  Jane Guo,et al.  TNF‐induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53 , 1998, European journal of immunology.

[66]  S. Ohsawa,et al.  Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis. , 2018, Developmental cell.

[67]  Anni Kleino,et al.  The Drosophila IMD pathway in the activation of the humoral immune response. , 2014, Developmental and comparative immunology.