Plasma Proinsulin-Like Components and Insulin in Chronic Liver Disease

In order to explain the increase of total IRI frequently observed at basal status, and after glucose administration, in patients with chronic liver disease, plasma proinsulin-like component and insulin levels have been studied in fourteen patients with liver cirrhosis associated or not with clinical or subclinical diabetes mellitus. A significative increase of plasma insulin was observed at basal status and after a glucose load not only in subjects with clinical or subclinical diabetes but also in those patients without carbohydrate abnormalities. This increase is apparently not correlated to any clinical characteristic and is associated in fasting and after glucose load with increased proinsulin-like component levels especially in patients with clinical or subclinical diabetes.

[1]  D. Steiner,et al.  The metabolism of proinsulin and insulin by the liver. , 1972, The Journal of clinical investigation.

[2]  D. Steiner,et al.  Human serum proinsulin. , 1970, The Journal of clinical investigation.

[3]  J. Roth,et al.  Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli. , 1969, The Journal of clinical investigation.

[4]  S. Berson,et al.  Significance of Human Plasma Insulin Sephadex Fractions , 1969, Diabetes.

[5]  N. Samaan,et al.  Serum glucose, insulin, and growth hormone in chronic hepatic cirrhosis. , 1969, Archives of internal medicine.

[6]  I. Pastan,et al.  "Big insulin": a new component of plasma insulin detected by immunoassay. , 1968, Proceedings of the National Academy of Sciences of the United States of America.

[7]  V. Marks,et al.  Glucose tolerance and diabetes in chronic liver disease. , 1967, Lancet.

[8]  K. Kosaka,et al.  Plasma insulin responses to glucose in femoral, hepatic, and pancreatic veins in dogs. , 1966, The American journal of physiology.

[9]  K. Seige.  [LIVER DISEASES AND DIABETES MELLITUS]. , 1963, Zeitschrift fur arztliche Fortbildung.

[10]  P. Davoren.  The isolation of insulin from a single cat pancreas. , 1962, Biochimica et biophysica acta.

[11]  P. Gorden,et al.  Glucose intolerance with hypokalemia: an increased proportion of circulating proinsulin-like component. , 1972, The Journal of clinical endocrinology and metabolism.

[12]  A. Vannotti,et al.  Tolérance au glucose diminuée et réponse insulinique élevée dans la cirrhose. , 1967 .