An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

[1]  Anjanabha Saha,et al.  Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation , 2008, Molecular cell.

[2]  Daniel C. Scott,et al.  Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation , 2008, Cell.

[3]  Anindya Dutta,et al.  ATR Pathway Is the Primary Pathway for Activating G2/M Checkpoint Induction After Re-replication* , 2007, Journal of Biological Chemistry.

[4]  Richard Pazdur,et al.  Bortezomib for the Treatment of Mantle Cell Lymphoma , 2007, Clinical Cancer Research.

[5]  Youngjo Kim,et al.  Cdt1 degradation to prevent DNA re-replication: conserved and non-conserved pathways , 2007, Cell Division.

[6]  M. Hochstrasser,et al.  Modification of proteins by ubiquitin and ubiquitin-like proteins. , 2006, Annual review of cell and developmental biology.

[7]  D. Cortez,et al.  DDB1 Maintains Genome Integrity through Regulation of Cdt1 , 2006, Molecular and Cellular Biology.

[8]  J. Wade Harper,et al.  Drug discovery in the ubiquitin–proteasome system , 2006, Nature Reviews Drug Discovery.

[9]  K. Nakayama,et al.  Two E3 ubiquitin ligases, SCF‐Skp2 and DDB1‐Cul4, target human Cdt1 for proteolysis , 2006, The EMBO journal.

[10]  Keith D Wilkinson,et al.  The discovery of ubiquitin-dependent proteolysis , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Anindya Dutta,et al.  Right Place, Right Time, and Only Once: Replication Initiation in Metazoans , 2005, Cell.

[12]  A. Hershko,et al.  The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle* , 2005, Cell Death and Differentiation.

[13]  F. Cross,et al.  Disruption of Mechanisms That Prevent Rereplication Triggers a DNA Damage Response , 2005, Molecular and Cellular Biology.

[14]  Raymond J. Deshaies,et al.  Function and regulation of cullin–RING ubiquitin ligases , 2005, Nature Reviews Molecular Cell Biology.

[15]  J. Walter,et al.  Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. , 2005, Genes & development.

[16]  S. Elledge,et al.  Recognition of Phosphodegron Motifs in Human Cyclin E by the SCFFbw7 Ubiquitin Ligase* , 2004, Journal of Biological Chemistry.

[17]  C. McCall,et al.  Targeted ubiquitination of CDT1 by the DDB1–CUL4A–ROC1 ligase in response to DNA damage , 2004, Nature Cell Biology.

[18]  Masayuki Yamamoto,et al.  Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 , 2004, Molecular and Cellular Biology.

[19]  Anindya Dutta,et al.  Rereplication by Depletion of Geminin Is Seen Regardless of p53 Status and Activates a G2/M Checkpoint , 2004, Molecular and Cellular Biology.

[20]  Y. Minami,et al.  Rapid Degradation of Cdt1 upon UV-induced DNA Damage Is Mediated by SCFSkp2 Complex* , 2004, Journal of Biological Chemistry.

[21]  Keiji Tanaka,et al.  Cullin-based ubiquitin ligase and its control by NEDD8-conjugating system. , 2004, Current protein & peptide science.

[22]  J. Bartek,et al.  Loss of Geminin induces rereplication in the presence of functional p53 , 2004, The Journal of cell biology.

[23]  D. C. Dias,et al.  Nedd8 on cullin: building an expressway to protein destruction , 2004, Oncogene.

[24]  A. Behrens,et al.  The Ubiquitin Ligase SCFFbw7 Antagonizes Apoptotic JNK Signaling , 2004, Science.

[25]  Richard Pazdur,et al.  Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy. , 2003, The oncologist.

[26]  David W. Miller,et al.  The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. , 2003, Molecular cell.

[27]  Jianyu Zheng,et al.  Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint , 2003, Nature Cell Biology.

[28]  Xiaohua Wu,et al.  The SCFSkp2 Ubiquitin Ligase Complex Interacts with the Human Replication Licensing Factor Cdt1 and Regulates Cdt1 Degradation* , 2003, Journal of Biological Chemistry.

[29]  A. Haas,et al.  Conservation in the Mechanism of Nedd8 Activation by the Human AppBp1-Uba3 Heterodimer* , 2003, Journal of Biological Chemistry.

[30]  P. Jackson,et al.  Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. , 2003, Developmental cell.

[31]  Anindya Dutta,et al.  Geminin and p53: Deterrents to Re-replication in Human Cancer Cells , 2003, Cell cycle.

[32]  Anindya Dutta,et al.  A p53-dependent checkpoint pathway prevents rereplication. , 2003, Molecular cell.

[33]  B. Schulman,et al.  Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8 , 2003, Nature.

[34]  M. Pagano,et al.  Dual mode of degradation of Cdc25 A phosphatase , 2002, The EMBO journal.

[35]  Alexander Varshavsky,et al.  The ubiquitin system. , 1998, Annual review of biochemistry.

[36]  R. Conaway,et al.  Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[37]  E. Lightcap,et al.  A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[38]  V. Chau,et al.  Nedd8 Modification of Cul-1 Activates SCFβTrCP-Dependent Ubiquitination of IκBα , 2000, Molecular and Cellular Biology.

[39]  R. Neve,et al.  The Amyloid Precursor Protein-binding Protein APP-BP1 Drives the Cell Cycle through the S-M Checkpoint and Causes Apoptosis in Neurons* , 2000, The Journal of Biological Chemistry.

[40]  E. Yeh,et al.  Identification of the Activating and Conjugating Enzymes of the NEDD8 Conjugation Pathway* , 1999, The Journal of Biological Chemistry.

[41]  Stephen J. Elledge,et al.  The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro , 1999 .

[42]  S. Elledge,et al.  The SCF–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkBa and b-catenin and stimulates IkBa ubiquitination in vitro , 1999 .

[43]  Andrea C. Carrano,et al.  SKP 2 is required for ubiquitin-mediated degradation of the CDK inhibitor p 27 , 1999 .

[44]  A. Goldberg,et al.  Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules , 1994, Cell.

[45]  H. Weintraub,et al.  The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1 , 1992, Cell.

[46]  A. Haas,et al.  The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. , 1982, The Journal of biological chemistry.

[47]  C. Coutsogeorgopoulos,et al.  Inhibition of protein synthesis by 5'-sulfamoyladenosine. , 1971, Biochemistry.