Does nodular lymphocyte predominant Hodgkin's disease arise from progressively transformed germinal centres? A case report with an unusually prolonged history

A case is reported of nodular lymphocyte predominant Hodgkin's disease arising 13 years after the removal of a lymph node from the same site which showed marked progressive transformation of germinal centres. The morphological evidence for a histogenetic relationship between the two conditions is presented and discussed.

[1]  S. Poppema,et al.  Nodular lymphocyte predominance type of Hodgkin's disease is a germinal center lymphoma. , 1986, Laboratory investigation; a journal of technical methods and pathology.

[2]  A. Norton,et al.  Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues. , 1986, Journal of clinical pathology.

[3]  B. Osborne,et al.  Clinical implications of progressive transformation of germinal centers , 1984, The American journal of surgical pathology.

[4]  T. Colby,et al.  Differential diagnostic features of nodular L&H Hodgkin's disease, including progressive transformation of germinal centers , 1984, The American journal of surgical pathology.

[5]  H Stein,et al.  Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). , 1984, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[6]  H. Stein,et al.  An immunohistological study of the cellular constituents of Hodgkin's disease using a monoclonal antibody panel , 1984, Histopathology.

[7]  R. Warnke,et al.  Diagnosis of human lymphoma with monoclonal antileukocyte antibodies. , 1983, The New England journal of medicine.

[8]  H. Stein,et al.  Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue. , 1983, Journal of clinical pathology.

[9]  J. Kearney,et al.  A monoclonal antibody (MMA) that identifies a differentiation antigen on human myelomonocytic cells. , 1982, Clinical immunology and immunopathology.

[10]  H. Stein,et al.  Human complement (C3b) receptors defined by a mouse monoclonal antibody. , 1982, Immunology.

[11]  M. R. Halie,et al.  The localization of Hodgkin's disease in lymph nodes. A study with immunohistological, enzyme histochemical and rosetting techniques on frozen sections , 1979, International journal of cancer.

[12]  K. Lennert,et al.  Hodgkin's disease with lymphocytic predominance, nodular type (nodular paragranuloma) and progressively transformed germinal centres—a cytohistological study , 1979, Histopathology.

[13]  R. Callard,et al.  Distinctive functional characteristics of human „T”︁ lymphocytes defined by E rosetting or a monoclonal anti‐T cell antibody , 1981, European journal of immunology.