In This study, a label-free detection method by using a novel Optofluidic ring resonator sensor (OFRR) structure is presented. Optofluidic is a developed young research subject suitable to create an appropriate cooperation between optics and fluidics. The combination of fluidic and optical methods achievable. by using the optofluidic methods makes it expedient to obtain an inventive type of sensors, which have been tried to have an ameliorate sensitivity, denseness and adaptivity. OFRR is a recent detection method that integrates Optic and fluid technologies with low-limit and low-cost and small- sample volume detection sensitivity. The objective of this article is the detection of the tuberculosis by offering a unique and a novel useful structure that is able to fabricate. The material of the proposed structure is PDMA that is completely flexible polymer. The width of the waveguide, the waveguide length and width of the ring of the proposed structure respectively is 500nm, 250 nm, 1500 nm. Also, the inner radius of the resonator ring in 4700 nm. The simulation Result of proposed structure by Opti-FDTD software shown 649 nm/RIS for the slope of the sensitivity curve.