SEXUAL DEPENDENCY OF RAT SCIATIC NERVE FIBER CONDUCTION VELOCITY DISTRIBUTIONS

Gender differences, either with the structural or through with hormones, dictate how the corresponding organ or organ system responses to physiological signals. Current study aims to investigate gender dependent differences in conduction related parameters of rat sciatic nerve. Compound action potentials (CAP) were recorded via suction electrode whereas the conduction velocity distributions (CVD) were performed using the method known as collision technique in the literature. Studied CAP parameters, namely conduction velocities (CV), area of the CAPs and time required to reach the maximum depolarization (TP) have been found significantly different for female and male rats. Detailed analyses have shown that sex dependent differences were more remarkable in the right leg responses of female and male rats. Additionally, CVDs indicate that the number of fibers having CVs between 5–30 m/s is much more in male right sciatic nerve trunk when compared to age matched female rats. The present study, for the first time clearly shows that shift in the contribution of nerve fibers to lower CVs is the main causal of the sex dependent differences seen in rat sciatic nerve fibers.

[1]  T. Miyatake,et al.  A new method to measure the distribution of motor conduction velocity in man. , 1991, Electroencephalography and clinical neurophysiology.

[2]  S. McMahon,et al.  Physiological properties of primary sensory neurons appropriately and inappropriately innervating skeletal muscle in adult rats. , 1991, Journal of neurophysiology.

[3]  S. Gozani,et al.  A method to improve the estimation of conduction velocity distributions over a short segment of nerve , 1999, IEEE Transactions on Biomedical Engineering.

[4]  J. H. Leal-Cardoso,et al.  Effects of estragole on the compound action potential of the rat sciatic nerve. , 2001, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[5]  I. Nadelhaft,et al.  Conduction velocity distribution of afferent fibers innervating the rat urinary bladder , 1990, Brain Research.

[6]  S. Panas,et al.  Bispectral de-noising of the compound action potential for estimation of the nerve conduction velocity distribution. , 1999, Medical engineering & physics.

[7]  M. Caccia,et al.  An electrophysiological method to assess the distribution of the sensory propagation velocity of the digital nerve in normal and diabetic subjects. , 1993, Electroencephalography and clinical neurophysiology.

[8]  L. Haberly,et al.  Membrane currents evoked by afferent fiber stimulation in rat piriform cortex. II. Analysis with a system model. , 1993, Journal of neurophysiology.

[9]  N. Dalkilic,et al.  A CORRECTION PROCEDURE FOR THE VOLUME CONDUCTOR EFFECT IN THE COMPOUND ACTION POTENTIAL RECORDED FROM ISOLATED NERVE TRUNK , 2002, The International journal of neuroscience.

[10]  P. Vera,et al.  Reduced urinary bladder afferent conduction velocities in streptozotocin diabetic rats , 1992, Neuroscience Letters.

[11]  Ü. Tan,et al.  Sex Differences in Verbal and Spatial Ability Reconsidered in Relation to Body Size Lung Volume, and Sex Hormones , 2003, Perceptual and motor skills.

[12]  Thomas Stretch Dowse,et al.  MUSCLE AND NERVE , 1903 .

[13]  L J Dorfman,et al.  The distribution of conduction velocities (DCV) in peripheral nerves: A review , 1984, Muscle & nerve.

[14]  T. Miyatake,et al.  A new method to measure the distribution of motor conducgtion velocity in man , 1991 .

[15]  I. Nadelhaft,et al.  The conduction velocity and segmental distribution of afferent fibers in the rectal nerves of the female rat , 1990, Brain Research.

[16]  S. Waxman.  Determinants of conduction velocity in myelinated nerve fibers , 1980, Muscle & nerve.

[17]  N. Forger.  Cell Death and Sexual Differentiation of the Nervous System , 2006 .

[18]  H. Hopf.  [Studies on the difference in the conductivity rate of motor nerve fibers in man]. , 1962, Deutsche Zeitschrift fur Nervenheilkunde.

[19]  R.E. Gander,et al.  Determination of nerve conduction velocity distribution from sampled compound action potential signals , 1996, IEEE Transactions on Biomedical Engineering.

[20]  Barkin Ilhan,et al.  SOMATOSENSORY CONDUCTION VELOCITY DISTRIBUTION OF MEDIAN NERVE MIDDLE PALMAR DIGITAL COMPONENT , 2004, The International journal of neuroscience.

[21]  G. R. Davis,et al.  The double collision technique: a new method for measurement of the motor nerve refractory period distribution in man. , 1987, Electroencephalography and clinical neurophysiology.

[22]  Ü. Tan,et al.  Covariation of Sex Differences in Mental Rotation with Body Size , 2003, Perceptual and motor skills.

[23]  Ü. Tan,et al.  DIFFERENTIAL CONTRIBUTIONS OF RIGHT AND LEFT BRAINS TO PAW SKILL IN RIGHT- AND LEFT-PAWED FEMALE RATS , 2003, The International journal of neuroscience.