In Vitro and In Vivo Assessment of Linezolid Combined with Ertapenem: a Highly Synergistic Combination against Methicillin-Resistant Staphylococcus aureus

ABSTRACT Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.

[1]  D. Hoban,et al.  Ertapenem: review of a new carbapenem , 2005, Expert review of anti-infective therapy.

[2]  E. Batard,et al.  In Vitro and In Vivo Synergistic Activities of Linezolid Combined with Subinhibitory Concentrations of Imipenem against Methicillin-Resistant Staphylococcus aureus , 2005, Antimicrobial Agents and Chemotherapy.

[3]  V. Lorian Antibiotics in laboratory medicine , 2005 .

[4]  E. Batard,et al.  In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus. , 2004, International journal of antimicrobial agents.

[5]  John S. Bradley,et al.  Practice Guidelines for Outpatient Parenteral Antimicrobial Therapy , 2004 .

[6]  P. Deutsch,et al.  Pharmacokinetics of Total and Unbound Ertapenem in Healthy Elderly Subjects , 2004, Antimicrobial Agents and Chemotherapy.

[7]  Fu-Yu Chiang,et al.  Efficacy of Linezolid Alone or in Combination with Vancomycin for Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus , 2003, Antimicrobial Agents and Chemotherapy.

[8]  J. K. Gibson,et al.  Efficacy of Linezolid plus Rifampin in an Experimental Model of Methicillin-Susceptible Staphylococcus aureus Endocarditis , 2003, Antimicrobial Agents and Chemotherapy.

[9]  E. Batard,et al.  In Vivo Efficacy of Continuous Infusion versus Intermittent Dosing of Linezolid Compared to Vancomycin in a Methicillin-Resistant Staphylococcus aureus Rabbit Endocarditis Model , 2002, Antimicrobial Agents and Chemotherapy.

[10]  Mary Jane Ferraro,et al.  Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically : approved standard , 2000 .

[11]  N. Ozawa,et al.  Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography. , 1999, Journal of pharmaceutical and biomedical analysis.

[12]  D. Musson,et al.  High-performance liquid chromatographic methods for the determination of a new carbapenem antibiotic, L-749,345, in human plasma and urine. , 1998, Journal of chromatography. B, Biomedical sciences and applications.

[13]  J. Caillon,et al.  In vivo simulation of human pharmacokinetics in the rabbit , 1998, Bulletin of mathematical biology.

[14]  J. Waitz Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically , 1990 .

[15]  J. Caillon,et al.  Dynamics of ceftazidime-pefloxacin interaction shown by a new killing curve-chequerboard method. , 1987, The Journal of antimicrobial chemotherapy.

[16]  R. Pearson,et al.  Method of reliable determination of minimal lethal antibiotic concentrations , 1980, Antimicrobial Agents and Chemotherapy.

[17]  E. Bruck,et al.  National Committee for Clinical Laboratory Standards. , 1980, Pediatrics.

[18]  R. Rucker,et al.  Outpatient intravenous medications in the management of cystic fibrosis. , 1974, Pediatrics.

[19]  D. Durack,et al.  Experimental Bacterial Endocarditis: II. Survival of Bacteria in Endocardial Vegetations , 1972 .

[20]  B. Perlman,et al.  Experimental endocarditis. II. Staphylococcal infection of the aortic valve following placement of a polyethylene catheter in the left side of the heart. , 1971, The Yale journal of biology and medicine.

[21]  L. Garrod,et al.  Methods of testing combined antibiotic bactericidal action and the significance of the results , 1962, Journal of clinical pathology.