Prenatal diagnosis of fetal cerebral abnormalities by ultrasonography and magnetic resonance imaging.

We found magnetic resonance imaging (MRI) of the fetal brain to be effective in confirming or denying diagnosis of fetal cerebral defects when ultrasonography was inconclusive or incomplete. In this paper we describe 31 cases in which ultrasonographic evidence of fetal brain defects was verified by MRI. MRI was performed after curarization of the fetus. In 21 cases, ultrasonographic evidence was confirmed by histological study of the fetus or postnatal radiological examination. In 10 cases, ultrasonographic diagnosis was denied by MRI and healthy infants were born. In one case of cerebral toxoplasmosis, ultrasonography detected periventricular calcifications but MRI was normal. In 20 cases MRI ascertained or further documented the ultrasonographic findings. However in 4 of these 20 cases autopsy of the fetus was required to determine the exact nature of the lesion.

[1]  N. Girard,et al.  In vivo MRI of fetal brain cellular migration. , 1992, Journal of computer assisted tomography.

[2]  J. Weinreb,et al.  Human fetal anatomy: MR imaging. , 1985, Radiology.

[3]  P Mansfield,et al.  Rapid biomedical imaging by NMR. , 1981, The British journal of radiology.

[4]  W. Yuh,et al.  Magnetic Resonance Imaging of Fetuses With Intracranial Defects , 1991, Obstetrics and gynecology.

[5]  R. Deter,et al.  The use of fetal neuromuscular blockade during intrauterine procedures. , 1987, American journal of obstetrics and gynecology.

[6]  J. Weinreb,et al.  Magnetic resonance imaging in obstetric diagnosis. , 1985, Radiology.

[7]  F. Daffos,et al.  Fetal blood sampling during pregnancy with use of a needle guided by ultrasound: a study of 606 consecutive cases. , 1985, American journal of obstetrics and gynecology.

[8]  P. Morris,et al.  The effects of NMR exposure on living organisms. I. A microbial assay. , 1981, The British journal of radiology.

[9]  Magnetic resonance imaging (MRI) in obstetrics. II. Fetal anatomy , 1988 .

[10]  B. Corke,et al.  Prevention of fetal movement during invasive procedures with pancuronium bromide. , 1986, American journal of obstetrics and gynecology.

[11]  L. Doyle,et al.  Ultrasound-Guided Fetal Blood Transfusion for Severe Rhesus Isoimmunization , 1985, Obstetrics and gynecology.

[12]  E. Cabanis,et al.  Fetal curarization for prenatal magnetic resonance imaging , 1988, Prenatal diagnosis.

[13]  B S Worthington,et al.  Imaging the pregnant human uterus with nuclear magnetic resonance. , 1984, American journal of obstetrics and gynecology.

[14]  H. Kressel,et al.  MR Imaging of Cerebral Abnormalities In Utero , 1984, Journal of computer assisted tomography.

[15]  T W Lowe,et al.  Magnetic Resonance Imaging in Human Pregnancy , 1985, Obstetrics and gynecology.

[16]  M. Cariati,et al.  Hydrocephalus and porencephaly: prenatal diagnosis by ultrasonography and MR imaging. , 1990, Journal of computer assisted tomography.

[17]  L. Crooks,et al.  NMR imaging produces no observable mutations or cytotoxicity in mammalian cells. , 1982, AJR. American journal of roentgenology.

[18]  J. Minogue,et al.  Fetal heart rate changes after fetal intravascular treatment with pancuronium bromide. , 1988, American journal of obstetrics and gynecology.

[19]  R. Dominguez,et al.  Intrauterine diagnosis of hydranencephaly by magnetic resonance. , 1989, Magnetic resonance imaging.

[20]  N. Girard,et al.  MRI study of brain myelination. , 1991, Journal of neuroradiology. Journal de neuroradiologie.

[21]  P. Morris,et al.  The effects of NMR exposure on living organisms. II. A genetic study of human lymphocytes. , 1981, The British journal of radiology.

[22]  J. Hutchison,et al.  Nuclear magnetic resonance imaging and its safety implications: follow-up of 181 patients. , 1982, The British journal of radiology.