Coregulation of pathways in lung cancer patients with EGFR mutation: therapeutic opportunities
暂无分享,去创建一个
R. Rosell | A. Cardona | M. Santarpia | O. Arrieta | J. Codony-Servat | A. Aguilar | M. Ito | C. Pedraz
[1] Daosheng Huang,et al. Chimeric STAR receptors using TCR machinery mediate robust responses against solid tumors , 2021, Science Translational Medicine.
[2] B. Cao,et al. Epiregulin confers EGFR-TKI resistance via EGFR/ErbB2 heterodimer in non-small cell lung cancer , 2021, Oncogene.
[3] James M. McFarland,et al. Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition , 2021, Nature.
[4] G. Goodall,et al. Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling , 2021, The Journal of cell biology.
[5] Jing Wang,et al. Characterization of the immune landscape of EGFR-mutant NSCLC identifies CD73/adenosine pathway as a potential therapeutic target. , 2020, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[6] M. Huang,et al. Selective exosome exclusion of miR-375 by glioma cells promotes glioma progression by activating the CTGF-EGFR pathway , 2020, Journal of experimental & clinical cancer research : CR.
[7] Ashutosh Kumar Singh,et al. Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK directed activation of NF-κB , 2020, Oncogene.
[8] Ying Liang,et al. Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. , 2020, Cancer cell.
[9] Yi-Wen Chang,et al. STAT3 phosphorylation at Ser727 and Tyr705 differentially regulates the EMT–MET switch and cancer metastasis , 2020, Oncogene.
[10] R. Birge,et al. Axl and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Antitumor Immunity , 2020, Cancer Research.
[11] M. Vasconcelos,et al. Chitinase 3-like-1 and fibronectin in the cargo of extracellular vesicles shed by human macrophages influence pancreatic cancer cellular response to gemcitabine. , 2020, Cancer letters.
[12] Yang Zhang,et al. KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway , 2020, Cell Death & Differentiation.
[13] M. Sos,et al. The next tier of EGFR resistance mutations in lung cancer , 2020, Oncogene.
[14] Ying Cheng,et al. Refined Stratification Based on Baseline Concomitant Mutations and Longitudinal circulating tumor DNA Monitoring in Advanced EGFR-mutant Lung Adenocarcinoma under Gefitinib Treatment. , 2020, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[15] E. Dmitrovsky,et al. A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components , 2020, Science Translational Medicine.
[16] Maohui Luo,et al. Multi-organ proteomic landscape of COVID-19 autopsies , 2020, Cell.
[17] S. Chiou,et al. Cross-talk between SOX2 and TGFβ Signaling Regulates EGFR–TKI Tolerance and Lung Cancer Dissemination , 2020, Cancer Research.
[18] Jian Ma,et al. Interaction of non-coding RNAs and Hippo signaling: Implications for tumorigenesis. , 2020, Cancer letters.
[19] Joshua D. Campbell,et al. Whole genome doubling confers unique genetic vulnerabilities on tumor cells , 2020, Nature.
[20] E. Jho,et al. MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis , 2020, Proceedings of the National Academy of Sciences.
[21] M. Hung,et al. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. , 2020, Cancer cell.
[22] Oliver Fiehn,et al. A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors , 2020, Cell.
[23] A. Gemma,et al. Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study. , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[24] A. Dutt,et al. Gefitinib Versus Gefitinib Plus Pemetrexed and Carboplatin Chemotherapy in EGFR-Mutated Lung Cancer. , 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] D. Pe’er,et al. Tumor Analyses Reveal Squamous Transformation and Off-Target Alterations As Early Resistance Mechanisms to First-line Osimertinib in EGFR-Mutant Lung Cancer , 2020, Clinical Cancer Research.
[26] Henry W. Long,et al. Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway. , 2020, Cancer cell.
[27] M. Okada,et al. Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma , 2019, Cell Communication and Signaling.
[28] M. Tschan,et al. Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma , 2019, Cell Death & Disease.
[29] D. Pe’er,et al. Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes. , 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[30] E. Giovannetti,et al. Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer , 2019, British Journal of Cancer.
[31] Hongzhuan Chen,et al. Acquired Resistance to EGFR TKIs Mediated by TGFβ1/Integrin β3 Signaling in EGFR-Mutant Lung Cancer , 2019, Molecular Cancer Therapeutics.
[32] K. Guan,et al. The Hippo Pathway: Biology and Pathophysiology. , 2019, Annual review of biochemistry.
[33] R. Rosell,et al. AURKB as a target in non-small cell lung cancer with acquired resistance to anti-EGFR therapy , 2019, Nature Communications.
[34] Emanuel J. V. Gonçalves,et al. Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening , 2019, Nature Communications.
[35] J. Ahn,et al. Concurrent Genetic Alterations Predict the Progression to Target Therapy in EGFR‐Mutated Advanced NSCLC , 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.
[36] S. Yano,et al. AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells , 2019, Nature Communications.
[37] N. Yang,et al. NTRK1 is a positive regulator of YAP oncogenic function , 2018, Oncogene.
[38] Kwok-Kin Wong,et al. Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. , 2018, Cancer cell.
[39] Sourav Bandyopadhyay,et al. Aurora kinase A drives the evolution of resistance to third generation EGFR inhibitors in lung cancer , 2018, Nature Medicine.
[40] S. Bicciato,et al. Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4 , 2018, Nature Medicine.
[41] Ying Cheng,et al. Detection of EGFR mutations in plasma circulating tumour DNA as a selection criterion for first-line gefitinib treatment in patients with advanced lung adenocarcinoma (BENEFIT): a phase 2, single-arm, multicentre clinical trial. , 2018, The Lancet. Respiratory medicine.
[42] H. Hondermarck,et al. The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung , 2018, Scientific Reports.
[43] Sarah J. Kurley,et al. Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer , 2018, Nature Medicine.
[44] M. Ladanyi,et al. Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of Resistance , 2018, Clinical Cancer Research.
[45] S. Cascinu,et al. Resistance to EGFR inhibitors in non-small cell lung cancer: Clinical management and future perspectives. , 2018, Critical reviews in oncology/hematology.
[46] M. Okada,et al. Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-Small Cell Lung Cancer Associated With Poor Prognosis , 2018, EBioMedicine.
[47] A. Shaw,et al. Tumour heterogeneity and resistance to cancer therapies , 2018, Nature Reviews Clinical Oncology.
[48] C. Zahnow,et al. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells , 2018, Proceedings of the National Academy of Sciences.
[49] J. Werner,et al. β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer. , 2018, Cancer cell.
[50] Edward S. Kim,et al. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers , 2017, Science Translational Medicine.
[51] W. Park,et al. Antifibrotic effects of pentoxifylline improve the efficacy of gemcitabine in human pancreatic tumor xenografts , 2017, Cancer science.
[52] T. Bivona,et al. Understanding and targeting resistance mechanisms in NSCLC , 2017, Nature Reviews Cancer.
[53] Maximilian Diehn,et al. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers , 2017, Nature Genetics.
[54] H. Ditzel,et al. Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer , 2017, Nature Communications.
[55] Amanda R. Kulick,et al. SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer. , 2017, Cancer research.
[56] Xianming Deng,et al. Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2. , 2017, Cancer cell.
[57] R. Rosell,et al. Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC) , 2017, Oncotarget.
[58] M. Kirschner,et al. Hippo pathway mediates resistance to cytotoxic drugs , 2017, Proceedings of the National Academy of Sciences.
[59] Zhike Lu,et al. m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program. , 2017, Cancer cell.
[60] H. Ditzel,et al. Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC , 2017, Journal of the National Cancer Institute.
[61] Yan Liang,et al. Autocrine activity of BDNF induced by the STAT3 signaling pathway causes prolonged TrkB activation and promotes human non-small-cell lung cancer proliferation , 2016, Scientific Reports.
[62] Xiaoxiao Sun,et al. Receptor Tyrosine Kinase Phosphorylation Pattern–Based Multidrug Combination Is an Effective Approach for Personalized Cancer Treatment , 2016, Molecular Cancer Therapeutics.
[63] L. Richard,et al. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells , 2016, Oncotarget.
[64] N. Tonks,et al. HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer , 2016, Genes & development.
[65] Tzu-chin Wu,et al. PAK1 Is a Novel Therapeutic Target in Tyrosine Kinase Inhibitor–Resistant Lung Adenocarcinoma Activated by the PI3K/AKT Signaling Regardless of EGFR Mutation , 2016, Clinical Cancer Research.
[66] J. Arbiser,et al. Inhibition of FoxM1-Mediated DNA Repair by Imipramine Blue Suppresses Breast Cancer Growth and Metastasis , 2016, Clinical Cancer Research.
[67] Suyun Huang,et al. HGF/Met and FOXM1 Form a Positive Feedback Loop and Render Pancreatic Cancer Cells Resistance to Met Inhibition and Aggressive Phenotypes , 2015, Oncogene.
[68] P. Jänne,et al. Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer. , 2015, Cancer discovery.
[69] Angela Tam,et al. AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas. , 2015, Cancer cell.
[70] John T. Chang,et al. A gp130–Src–YAP module links inflammation to epithelial regeneration , 2015, Nature.
[71] Naveid A Ali,et al. The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking , 2015, Science Signaling.
[72] T. Golub,et al. Genetic modifiers of EGFR dependence in non-small cell lung cancer , 2014, Proceedings of the National Academy of Sciences.
[73] E. Haura,et al. Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer , 2014, Clinical Cancer Research.
[74] G. Kéri,et al. Connective tissue growth factor is a new ligand of epidermal growth factor receptor. , 2013, Journal of molecular cell biology.
[75] A. Ullrich,et al. HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitors , 2013, Oncogene.
[76] Li Zhang,et al. Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial. , 2013, The Lancet. Oncology.
[77] R. Rosell. Mediating resistance in oncogene-driven cancers. , 2013, The New England journal of medicine.
[78] R. Bernards,et al. MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling , 2012, Cell.
[79] Peijing Zhang,et al. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker , 2012, Nature Medicine.
[80] P. Bunn,et al. Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition. , 2012, Cancer research.
[81] Jae Cheol Lee,et al. Activation of the AXL Kinase Causes Resistance to EGFR-Targeted Therapy in Lung Cancer , 2012, Nature Genetics.
[82] B. Halmos,et al. MET-independent lung cancer cells evading EGFR kinase inhibitors are therapeutically susceptible to BH3 mimetic agents. , 2011, Cancer research.
[83] A. Stemmer-Rachamimov,et al. A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions. , 2011, Cancer cell.
[84] H. Hieronymus,et al. FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR , 2011, Nature.
[85] S. Digumarthy,et al. Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors , 2011, Science Translational Medicine.
[86] M. Rao,et al. Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase , 2011, Cell.
[87] M. Meyerson,et al. PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR. , 2009, Cancer research.
[88] W. Gerald,et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas. , 2007, The Journal of clinical investigation.
[89] Keith L. Ligon,et al. Coactivation of Receptor Tyrosine Kinases Affects the Response of Tumor Cells to Targeted Therapies , 2007, Science.
[90] Daniel A. Haber,et al. Gefitinib-Sensitizing EGFR Mutations in Lung Cancer Activate Anti-Apoptotic Pathways , 2004, Science.
[91] An Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer. , 2018, Cancer discovery.
[92] D. Takai,et al. FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer. , 2013, International journal of clinical and experimental pathology.