Synchronization coupling investigation using ICA cluster analysis in resting MEG signals in reading difficulties

The understanding of the mechanisms of human brain is a demanding issue for neuroscience research. Physiological studies acknowledge the usefulness of synchronization coupling in the study of dysfunctions associated with reading difficulties. Magnetoencephalogram (MEG) is a useful tool towards this direction having been assessed for its superior accuracy over other modalities. In this paper we consider synchronization features for identifying brain operations. Independent Component Analysis (ICA) is applied on MEG surface signals in controls and children with reading difficulties and are clustered to representative components. Then, coupling measures of mutual information and partial directed coherence are estimated in order to reveal dysfunction of cerebral networks and its related coordination.

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