Small molecule targeting FOXM1 DNA binding domain exhibits anti-tumor activity in ovarian cancer

[1]  Haiyang Guo,et al.  Cyclin F and KIF20A, FOXM1 target genes, increase proliferation and invasion of ovarian cancer cells. , 2020, Experimental cell research.

[2]  D. Schuster,et al.  Modulating FOXO3 transcriptional activity by small, DBD-binding molecules , 2019, eLife.

[3]  Benjamin G. Bitler,et al.  Activation of Wnt signaling promotes olaparib resistant ovarian cancer , 2019, Molecular carcinogenesis.

[4]  Ahmedin Jemal,et al.  Cancer treatment and survivorship statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[5]  Xuegong Fan,et al.  FOXM1 contributes to taxane resistance by regulating UHRF1-controlled cancer cell stemness , 2018, Cell Death & Disease.

[6]  Jun Liang,et al.  FoxM1 promotes epithelial-mesenchymal transition of hepatocellular carcinoma by targeting Snai1 , 2017, Molecular medicine reports.

[7]  A. Gartel FOXM1 in Cancer: Interactions and Vulnerabilities. , 2017, Cancer research.

[8]  Yongjun Tan,et al.  Suppression of FOXM1 Transcriptional Activities via a Single-Stranded DNA Aptamer Generated by SELEX , 2017, Scientific Reports.

[9]  N. Vilaboa,et al.  New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumor cell survival , 2017, Nucleic acids research.

[10]  Y. Gambin,et al.  Small-Molecule Inhibitors of the SOX18 Transcription Factor. , 2017, Cell chemical biology.

[11]  Feimeng Zheng,et al.  FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells , 2017, Oncogene.

[12]  H. Ngan,et al.  DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling , 2016, Oncogene.

[13]  Liankun Sun,et al.  Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases , 2016, International journal of molecular sciences.

[14]  C. J. Wang,et al.  Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo , 2016, Oncogene.

[15]  Ash A. Alizadeh,et al.  Abstract PR09: The prognostic landscape of genes and infiltrating immune cells across human cancers , 2015 .

[16]  Michael V. Gormally,et al.  Suppression of the FOXM1 transcriptional program via novel small molecule inhibition , 2014, Nature Communications.

[17]  N. Seki,et al.  Tumour‐suppressive microRNA‐24‐1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer , 2014, FEBS letters.

[18]  Zhuo-rong Li,et al.  Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction. , 2014, European journal of medicinal chemistry.

[19]  Ting Liu,et al.  FOXM1 Modulates Cisplatin Sensitivity by Regulating EXO1 in Ovarian Cancer , 2014, PloS one.

[20]  Yi Wang,et al.  Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell proliferation, migration and invasion in epithelial ovarian cancer , 2014, Journal of Translational Medicine.

[21]  Yongjun Tan,et al.  FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer. , 2013, Cancer letters.

[22]  I. Wierstra,et al.  FOXM1 (Forkhead box M1) in tumorigenesis: overexpression in human cancer, implication in tumorigenesis, oncogenic functions, tumor-suppressive properties, and target of anticancer therapy. , 2013, Advances in cancer research.

[23]  A. Al-Niaimi,et al.  Epithelial ovarian cancer. , 2012, Obstetrics and gynecology clinics of North America.

[24]  P. Aloy,et al.  Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence , 2010, Nucleic acids research.

[25]  Raymond Sawaya,et al.  FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. , 2008, Cancer research.

[26]  Renxiao Wang,et al.  A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.