Dietary restriction delays cataract and reduces ascorbate levels in Emory mice.

[1]  J. H. Roe,et al.  THE DETERMINATION OF ASCORBIC ACID IN WHOLE BLOOD AND URINE THROUGH THE 2,4-DINITROPHENYLHYDRAZINE DERIVATIVE OF DEHYDROASCORBIC ACID , 1943 .

[2]  D. Harman.  Aging: a theory based on free radical and radiation chemistry. , 1956, Journal of gerontology.

[3]  A. Lehninger,et al.  Enzymic synthesis of L-ascorbic acid in different animal species. , 1957, Archives of biochemistry and biophysics.

[4]  R. D. Richards,et al.  Induction of cataracts in mice by exposure to oxygen. , 1972, Israel journal of medical sciences.

[5]  J. Koziol,et al.  A distribution-free test for tumor-growth curve analyses with application to an animal tumor immunotherapy experiment. , 1981, Biometrics.

[6]  V. Raisys,et al.  Ascorbic acid in lymphocytes: cell preparation and liquid-chromatographic assay. , 1982, Clinical chemistry.

[7]  J. Kuck,et al.  The Emory mouse cataract: loss of soluble protein, glutathione, protein sulfhydryl and other changes. , 1983, Experimental eye research.

[8]  R. Weindruch,et al.  Dietary restriction retards age-related loss of gamma crystallins in the mouse lens. , 1984, Science.

[9]  K. Bensch,et al.  The role of ascorbic acid in senile cataract. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Weindruch,et al.  The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. , 1986, The Journal of nutrition.

[11]  A Taylor,et al.  Delay of UV-induced eye lens protein damage in guinea pigs by dietary ascorbate. , 1986, Journal of free radicals in biology & medicine.

[12]  L. Machlin,et al.  Third Conference on Vitamin C. , 1987, Annals of the New York Academy of Sciences.

[13]  C. Tsao,et al.  Effect of dietary ascorbic acid intake on tissue vitamin C in mice. , 1987, The Journal of nutrition.

[14]  S. Varma.  Ascorbic Acid and the Eye with Special Reference to the Lens , 1987, Annals of the New York Academy of Sciences.

[15]  R. Weindruch,et al.  Influences of dietary restriction and age on liver enzyme activities and lipid peroxidation in mice. , 1987, The Journal of nutrition.

[16]  Allen Taylor,et al.  Measures of leucine aminopeptidase can be used to anticipate UV-induced age-related damage to lens proteins: Ascorbate can delay this damage , 1987, Mechanisms of Ageing and Development.

[17]  Richard Weindruch,et al.  The Retardation of Aging and Disease by Dietary Restriction , 1988 .

[18]  E. Masoro.  Food restriction in rodents: an evaluation of its role in the study of aging. , 1988, Journal of gerontology.

[19]  B. Yu,et al.  Effect of chronic food restriction in aging rats II. Liver cytosolic antioxidants and related enzymes , 1989, Mechanisms of Ageing and Development.

[20]  Shumei S. Guo,et al.  MUDIFT: Multivariate Distribution-Free Comparison of Growth Curves , 1989 .

[21]  M. V. Varoni,et al.  Effect of adriamycin and of d-amphetamine on endogenous levels of ascorbic acid in rodents. , 1989, Pharmacological research.

[22]  B. Ames,et al.  Ascorbate is an outstanding antioxidant in human blood plasma. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[23]  C. Tsao,et al.  Effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice. , 1989, Life sciences.

[24]  A. Taylor,et al.  Relationship between dietary intake and tissue levels of reduced and total vitamin C in the nonscorbutic guinea pig. , 1989, The Journal of nutrition.

[25]  G. Dallal.  cLOGISTIC: A Conditional Logistic Regression Program for the IBM PC , 1989 .

[26]  J. Trevithick,et al.  Vitamin E Intake and Risk of Cataracts in Humans a , 1989, Annals of the New York Academy of Sciences.

[27]  G E Dallal,et al.  Moderate caloric restriction delays cataract formation in the Emory mouse , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  J. Trevithick,et al.  Modelling cortical cataractogenesis. XI. Vitamin C reduces gamma-crystallin leakage from lenses in diabetic rats. , 1990, Experimental eye research.

[29]  J. Kuck.  Late onset hereditary cataract of the emory mouse. A model for human senile cataract. , 1990, Experimental eye research.

[30]  J. Blumberg,et al.  Dietary energy restriction decreases ex vivo spleen prostaglandin E2 synthesis in Emory mice. , 1990, The Journal of nutrition.

[31]  J. Liang,et al.  In vitro non-enzymatic glycation and formation of browning products in the bovine lens alpha-crystallin. , 1990, Experimental eye research.

[32]  V. Monnier,et al.  High correlation between pentosidine protein crosslinks and pigmentation implicates ascorbate oxidation in human lens senescence and cataractogenesis. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[33]  I. Shimokawa,et al.  Retardation of the Aging Processes in Rats by Food Restriction , 1991, Annals of the New York Academy of Sciences.

[34]  P. Jacques,et al.  Relationship in humans between ascorbic acid consumption and levels of total and reduced ascorbic acid in lens, aqueous humor, and plasma. , 1991, Current eye research.

[35]  W. Pierpaoli,et al.  Physiological Senescence and its Postponement: Theoretical Approaches and Rational Interventions. Second Stromboli Conference on Aging and Cancer. Stromboli, Sicily, May 28-June 1, 1990. Proceedings. , 1991, Annals of the New York Academy of Sciences.

[36]  H. Sauberlich,et al.  Beyond Deficiency: New Views on the Function and Health Effects of Vitamins. Conference proceedings. Arlington, Virginia, February 9-12, 1992. , 1992, Annals of the New York Academy of Sciences.

[37]  A. Meister,et al.  Glutathione deficiency increases hepatic ascorbic acid synthesis in adult mice. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[38]  A. Taylor,et al.  Role of Nutrients in Delaying Cataracts a , 1992, Annals of the New York Academy of Sciences.

[39]  P. Jacques,et al.  Oxidation and Aging: Impact on Vision , 1993, Toxicology and industrial health.

[40]  A Taylor,et al.  Cataract incidence and analysis of lens crystallins in the water-, urea- and SDS-soluble fractions of Emory mice fed a diet restricted by 40% in calories. , 1993, Current eye research.

[41]  J. Trevithick,et al.  Modelling cortical cataractogenesis. 13. Early effects on lens ATP/ADP and glutathione in the streptozotocin rat model of the diabetic cataract. , 1993, Experimental eye research.

[42]  B. S. Winkler,et al.  The redox couple between glutathione and ascorbic acid: a chemical and physiological perspective. , 1994, Free radical biology & medicine.

[43]  B. Teter,et al.  Studies on Emory mouse cataracts: oxidative factors. , 1994, Ophthalmic Research.

[44]  B. Frei.  Natural antioxidants in human health and disease , 1994 .

[45]  Gerard E. Dallal,et al.  Dietary calorie restriction in the Emory mouse: effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity, and cancer , 1995, Mechanisms of Ageing and Development.