Structural Basis of Cortical Monoamine Function

The title of this chapter suggests that it is possible, in the current state of knowledge, to elaborate meaningful hypotheses regarding the mode of action and function of certain sets of CNS neurons based on the characteristics of their morphological organization. Not so very long ago, such a nosological approach would have been hazardous if not presumptuous. The coherence of physio-logical and biochemical results ensured their validity and absolved these disciplines from striving for precise cellular localization. On their side, anatomists often relied on purely spatial descrip-tions of the distribution, configuration, and connectivity of nerve cells to seek some rather primitive understanding of their integrated functioning in mere terms of excitation and inhibition. Nowadays, few neuroscientists would dare to envisage any aspect of a higher neural system without due attention to the varied and interrelated facets of its morphofunctional organization. Herbert H. Jasper has given us leading examples of such broad thinking. The present essay draws heavily on some of his ideas.

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