Functional aspects of meningeal lymphatics in aging and Alzheimer’s disease

[1]  Cindi M Morshead,et al.  A hydrogel composite system for sustained epi-cortical delivery of Cyclosporin A to the brain for treatment of stroke. , 2013, Journal of controlled release : official journal of the Controlled Release Society.

[2]  James C. Cronk,et al.  Wild type microglia arrest pathology in a mouse model of Rett syndrome , 2012, Nature.

[3]  B. Bachmann,et al.  Age-related changes in murine limbal lymphatic vessels and corneal lymphangiogenesis. , 2008, Experimental eye research.

[4]  M. Swartz,et al.  Optimization and regeneration kinetics of lymphatic-specific photodynamic therapy in the mouse dermis , 2013, Angiogenesis.

[5]  M. Geschwind,et al.  Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. , 2018, Cold Spring Harbor perspectives in biology.

[6]  K. Rhodes,et al.  Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease , 2017, Nature.

[7]  T. Nagai,et al.  Aging‐Associated Alterations in Contractility of Rat Mesenteric Lymphatic Vessels , 2011, Microcirculation.

[8]  G. Kempermann,et al.  An old test for new neurons: refining the Morris water maze to study the functional relevance of adult hippocampal neurogenesis , 2013, Front. Neurosci..

[9]  Michael Detmar,et al.  A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules , 2015 .

[10]  Julie A. Harris,et al.  Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein , 2010, The Journal of Neuroscience.

[11]  T. Veikkola,et al.  Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects , 2002, The Journal of experimental medicine.

[12]  I. Amit,et al.  A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease , 2017, Cell.

[13]  K. Zaghloul,et al.  Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI , 2017, eLife.

[14]  Timothy J Keyes,et al.  Structural and functional features of central nervous system lymphatics , 2015, Nature.

[15]  B. Strooper,et al.  The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes , 2012, Nature Neuroscience.

[16]  G. Hu,et al.  Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits , 2015, Molecular Neurodegeneration.

[17]  Jonathan Kipnis,et al.  Revisiting the Mechanisms of CNS Immune Privilege. , 2015, Trends in immunology.

[18]  M. Robinson,et al.  Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences. , 2015, F1000Research.

[19]  Qifa Zhou,et al.  Ultrasound-aided Multi-parametric Photoacoustic Microscopy of the Mouse Brain , 2015, Scientific Reports.

[20]  D. Holtzman,et al.  In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life , 2003, The Journal of Neuroscience.

[21]  Katie Hamm,et al.  apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. , 2008, The Journal of clinical investigation.

[22]  E. Feldman,et al.  Apolipoprotein E knockout as the basis for mouse models of dyslipidemia-induced neuropathy , 2013, Experimental Neurology.

[23]  K. Alitalo,et al.  Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans , 2015, Cell reports.

[24]  Maiken Nedergaard,et al.  Impairment of paravascular clearance pathways in the aging brain , 2014, Annals of neurology.

[25]  C. Janus Search strategies used by APP transgenic mice during navigation in the Morris water maze. , 2004, Learning & memory.

[26]  Bronwen L. Aken,et al.  GENCODE: The reference human genome annotation for The ENCODE Project , 2012, Genome research.

[27]  G. Ferland,et al.  Lymphatic absorption of retinol in young, mature, and old rats: influence of dietary restriction , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  G. E. Vates,et al.  A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β , 2012, Science Translational Medicine.

[29]  Sean Regan,et al.  Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease , 2016, Neurobiology of Disease.

[30]  R. Kauppinen,et al.  A model for gene therapy of human hereditary lymphedema , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Per Kristian Eide,et al.  Glymphatic MRI in idiopathic normal pressure hydrocephalus , 2017, Brain : a journal of neurology.

[32]  D. Cai,et al.  Hypothalamic Programming of Systemic Aging Involving IKKβ/NF-κB and GnRH , 2013, Nature.

[33]  W. Huber,et al.  Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.

[34]  J. Kipnis,et al.  Regulation of learning and memory by meningeal immunity: a key role for IL-4 , 2010, The Journal of experimental medicine.

[35]  Charles Duyckaerts,et al.  National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach , 2011, Acta Neuropathologica.

[36]  Guillermo Oliver,et al.  Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity , 2005, Nature Genetics.

[37]  A. Louveau,et al.  Impaired Spatial Memory in Mice Lacking CD3ζ Is Associated with Altered NMDA and AMPA Receptors Signaling Independent of T-Cell Deficiency , 2013, The Journal of Neuroscience.

[38]  M. Detmar,et al.  Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice. , 2016, JCI insight.

[39]  M. Drew,et al.  Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment , 2006, Nature Neuroscience.

[40]  Kang Hu,et al.  High-Level Neuronal Expression of Aβ1–42 in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation , 2000, The Journal of Neuroscience.

[41]  K. Alitalo,et al.  CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation , 2014, Circulation.

[42]  M. Robinson,et al.  Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences , 2015, F1000Research.

[43]  A. Mildner,et al.  Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease , 2011, The Journal of Neuroscience.

[44]  J. Schneider,et al.  Central role for PICALM in amyloid–β blood–brain barrier transcytosis and clearance , 2015, Nature Neuroscience.

[45]  J. Bibb,et al.  Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2 , 2015, Nature Communications.

[46]  B. Zlokovic,et al.  Pericyte loss influences Alzheimer-like neurodegeneration in mice , 2013, Nature Communications.

[47]  J. Kaye,et al.  Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains , 2017, JAMA neurology.

[48]  K. Alitalo,et al.  A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities* , 1998, The Journal of Biological Chemistry.

[49]  J. Kipnis Multifaceted interactions between adaptive immunity and the central nervous system , 2016, Science.

[50]  Anatol C. Kreitzer,et al.  Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease , 2007, Neuron.

[51]  Jay W. Shin,et al.  Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: a role for FGF signaling in lymphangiogenesis. , 2005, Molecular biology of the cell.

[52]  Andrew E. Jaffe,et al.  Bioinformatics Applications Note Gene Expression the Sva Package for Removing Batch Effects and Other Unwanted Variation in High-throughput Experiments , 2022 .

[53]  J. W. Rudy,et al.  Understanding contextual fear conditioning: insights from a two-process model , 2004, Neuroscience & Biobehavioral Reviews.

[54]  G. Fishell,et al.  Oxytocin enhancement of CA1 spike transmission by modulation of fast-spiking interneurons , 2013, Nature.

[55]  John D. Storey,et al.  Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis , 2007, PLoS genetics.

[56]  M. Ohno,et al.  Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation , 2006, The Journal of Neuroscience.

[57]  Guangchuang Yu,et al.  clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.

[58]  T. Bayer,et al.  Gene Dosage Dependent Aggravation of the Neurological Phenotype in the 5XFAD Mouse Model of Alzheimer's Disease. , 2015, Journal of Alzheimer's disease : JAD.

[59]  Ron Brookmeyer,et al.  Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States , 2018, Alzheimer's & Dementia.

[60]  Ann Marie Schmidt,et al.  RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain , 2003, Nature Medicine.

[61]  I. Immonen,et al.  Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis , 2011, Science Translational Medicine.

[62]  D. Selkoe,et al.  Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging , 1988, Brain Research.

[63]  Z. Lodin,et al.  Immunological tolerance and tumour allografts in the brain , 1977, Nature.

[64]  Rob Patro,et al.  Salmon provides fast and bias-aware quantification of transcript expression , 2017, Nature Methods.