Volumetric Magnetic Resonance Imaging Evidence of Bilateral Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy

Summary: Purpose: We measured absolute volumes and volume differences of hippocampi in patients with mesial temporal lobe epilepsy (MTLE) using volumetric magnetic resonance imaging (MRI) to determine the extent of bilateral atrophy in MTLE and to relate hippocampal volumes (HV) to outcome of temporal lobectomy.

[1]  G McCarthy,et al.  Bilateral Hippocampal Atrophy in Medial Temporal Lobe Epilepsy , 1995, Epilepsia.

[2]  A. Wyler,et al.  Extent of medial temporal resection on outcome from anterior temporal lobectomy: a randomized prospective study. , 1995 .

[3]  C. Adam,et al.  Value of magnetic resonance imaging-based measurements of hippocampal formations in patients with partial epilepsy. , 1994, Archives of neurology.

[4]  H. Lüders,et al.  Ictal scalp EEG in temporal lobe epilepsy with unitemporal versus bitemporal interictal epileptiform discharges , 1995, Neurology.

[5]  C R Jack,et al.  Bilaterally symmetric hippocampi and surgical outcome , 1995, Neurology.

[6]  A. Mouritze Dam.  Hippocampal neuron loss in epilepsy and after experimental seizures. , 1982, Acta neurologica Scandinavica.

[7]  D R Fish,et al.  Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. , 1992, Brain : a journal of neurology.

[8]  Alan C. Evans,et al.  MRI of Amygdala and Hippocampus in Temporal Lobe Epilepsy , 1993, Journal of computer assisted tomography.

[9]  S. Eisenschenk,et al.  Hippocampal volumetrics differentiate patients with temporal lobe epilepsy and extratemporal lobe epilepsy. , 1995, Archives of neurology.

[10]  H. Duvernoy.  The Human Hippocampus: An Atlas of Applied Anatomy , 1988 .

[11]  E. Bertram,et al.  The hippocampus in experimental chronic epilepsy: A morphometric analysis , 1990, Annals of neurology.

[12]  C R Jack,et al.  Magnetic resonance imaging–based volume studies in temporal lobe epilepsy: Pathological correlations , 1991, Annals of neurology.

[13]  M Ashtari,et al.  Three-dimensional fast low-angle shot imaging and computerized volume measurement of the hippocampus in patients with chronic epilepsy of the temporal lobe. , 1991, AJNR. American journal of neuroradiology.

[14]  A. M. Dam.  Hippocampal neuron loss in epilepsy and after experimental seizures , 1982 .

[15]  E. Lothman,et al.  Morphometric effects of intermittent kindled seizures and limbic status epilepticus in the dentate gyrus of the rat , 1993, Brain Research.

[16]  B P Hermann,et al.  Extent of medial temporal resection on outcome from anterior temporal lobectomy: a randomized prospective study. , 1995, Neurosurgery.

[17]  G McCarthy,et al.  Diagnosis of medial temporal lobe seizure onset , 1993, Neurology.

[18]  J. Mugler,et al.  Three‐dimensional magnetization‐prepared rapid gradient‐echo imaging (3D MP RAGE) , 1990, Magnetic resonance in medicine.

[19]  P. Gloor,et al.  MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy , 1993, Neurology.

[20]  A. Siegel,et al.  Relationships between MR-imaged total amount of tissue removed, resection scores of specific mediobasal limbic subcompartments and clinical outcome following selective amygdalohippocampectomy , 1990, Epilepsy Research.

[21]  F. Sharbrough,et al.  Depth Electrode Studies in Temporal Lobe Epilepsy: Relation to Quantitative Magnetic Resonance Imaging and Operative Outcome , 1995, Epilepsia.

[22]  C R Jack,et al.  Temporal lobe seizures: lateralization with MR volume measurements of the hippocampal formation. , 1990, Radiology.

[23]  P. Narayana,et al.  Accuracy and Reproducibility in Volumetric Analysis of Multiple Sclerosis Lesions , 1993, Journal of computer assisted tomography.

[24]  C R Jack,et al.  Magnetic resonance image–based hippocampal volumentry: Correlation with outcome after temporal lobectomy , 1992, Annals of neurology.

[25]  Jerome Engel,et al.  Outcome with respect to epileptic seizures. , 1993 .