Squamous Cell Carcinoma and Squamous Differentiation Histologic Variant of Urothelialcarcinoma of Urinary Bladder: Oncological Outcome Following Definitive Surgical Treatment

Objectives: To investigate the impact of variant histologic patterns of urothelialcarcinoma of the bladder on oncological outcomes of patients treated with Radical Cystectomy (RC). Three histologic patterns were evaluated: Urothelial Carcinoma (UC), Squamous Cell Carcinoma (SCC), and urothelial carcinoma with Squamous Differentiation (SqD). Materials and methods: Retrospective archival study included 258 patients treated with RCfor muscle-invasive carcinoma. Data were reviewed in demographic and clinicopathological parameters that included histopathological variant, tumor stage, and nodal status. Overall survival and cancer-specific survival were evaluated. Histologic patterns of these 258 patients were: 90 patients with UC, 112 patients with SCC, and 56 patients with UC with SqD. Archival data were retrieved from 1995 to 2012. Results: Median followup was 44 months. There were statistically significant differences between survivals in the three groups. Overall survival decreased in UC with SqD. Patients with SCC had a higher risk of local recurrence, while patients with pure UC had a higher risk of metastases. Conclusion: Squamous differentiation of UC was associated with high tumor stage and high tumor grade. Patients with this histologic variant had less favorable prognosis compared to pure UC and pure SCC. Diagnosis of divert histologic patterns in RC is valuable forplanning a treatment strategy.

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