Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures

The retinal and cerebral microvasculatures share many morphological and physiological properties. Assessment of the cerebral microvasculature requires highly specialized and expensive techniques. The potential for using non‐invasive clinical assessment of the retinal microvasculature as a marker of the state of the cerebrovasculature offers clear advantages, owing to the ease with which the retinal vasculature can be directly visualized in vivo and photographed due to its essential two‐dimensional nature. The use of retinal digital image analysis is becoming increasingly common, and offers new techniques to analyse different aspects of retinal vascular topography, including retinal vascular widths, geometrical attributes at vessel bifurcations and vessel tracking. Being predominantly automated and objective, these techniques offer an exciting opportunity to study the potential to identify retinal microvascular abnormalities as markers of cerebrovascular pathology. In this review, we describe the anatomical and physiological homology between the retinal and cerebral microvasculatures. We review the evidence that retinal microvascular changes occur in cerebrovascular disease and review current retinal image analysis tools that may allow us to use different aspects of the retinal microvasculature as potential markers for the state of the cerebral microvasculature.

[1]  J. Cunha-Vaz The blood-ocular barriers: past, present, and future , 2007, Documenta Ophthalmologica.

[2]  R. Traystman,et al.  Cerebrovascular transmural pressure and autoregulation , 1985, Annals of Biomedical Engineering.

[3]  M. Lorenzi,et al.  Studies on the permeability of the blood-brain barrier in experimental diabetes , 2006, Diabetologia.

[4]  Tan Xiao-mei,et al.  CADASIL , 2005 .

[5]  J. Weiter,et al.  Evaluation of micrometric and microdensitometric methods for measuring the width of retinal vessel images on fundus photographs , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[6]  D. Heistad,et al.  Prone Spontaneously Hypertensive Rats , 2005 .

[7]  A. Alm,et al.  Carrier-mediated transport of amino acids through the blood-retinal and the blood-brain barriers , 2005, Graefe's Archive for Clinical and Experimental Ophthalmology.

[8]  Ann M. Hosre,et al.  Contractile Responses of Isolated Bovine Retinal Microarteries to Acetylcholine , 2005 .

[9]  M. Dichgans,et al.  Histopathological abnormalities in ocular blood vessels of CADASIL patients. , 2004, American journal of ophthalmology.

[10]  Toke Bek,et al.  The age-dependent decrease in the myogenic response of retinal arterioles as studied with the Retinal Vessel Analyzer , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[11]  R. Klein,et al.  Prospective cohort study of retinal vessel diameters and risk of hypertension , 2004, BMJ : British Medical Journal.

[12]  Ines Lanzl,et al.  Age, blood pressure, and vessel diameter as factors influencing the arterial retinal flicker response. , 2004, Investigative ophthalmology & visual science.

[13]  M. Dichgans,et al.  Retinal vascular abnormalities in CADASIL , 2004, Neurology.

[14]  V. Mok,et al.  Cognitive impairment and functional outcome after stroke associated with small vessel disease , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[15]  Tien Yin Wong,et al.  Is retinal photography useful in the measurement of stroke risk? , 2004, The Lancet Neurology.

[16]  L. Kagemann,et al.  Reproducibility of circadian retinal and optic nerve head blood flow measurements by Heidelberg retina flowmetry , 2004, British Journal of Ophthalmology.

[17]  Tien Yin Wong,et al.  Retinal Arteriolar Diameter and Risk for Hypertension , 2004, Annals of Internal Medicine.

[18]  S. Thanos,et al.  Neuro-glial interactions in the adult rat retina after reaxotomy of ganglion cells: examination of neuron survival and phagocytic microglia using fluorescent tracers , 2004, Brain Research Bulletin.

[19]  F. Magrini,et al.  High prevalence of retinal vascular changes in never‐treated essential hypertensives: an inter‐ and intra‐observer reproducibility study with non‐mydriatic retinography , 2004, Blood pressure.

[20]  R. Klein,et al.  Variation associated with measurement of retinal vessel diameters at different points in the pulse cycle , 2003, The British journal of ophthalmology.

[21]  J. J. Wang,et al.  Retinal vessel wall signs and the 5 year incidence of age related maculopathy: the Blue Mountains Eye Study , 2003, The British journal of ophthalmology.

[22]  N. Abbott Inflammatory Mediators and Modulation of Blood–Brain Barrier Permeability , 2000, Cellular and Molecular Neurobiology.

[23]  T. Gustavsson,et al.  Morphometry of the optic nerve and retinal vessels in children by computer-assisted image analysis of fundus photographs , 1995, Graefe's Archive for Clinical and Experimental Ophthalmology.

[24]  P. R. Hof,et al.  Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders , 1994, Acta Neuropathologica.

[25]  V. Parisi,et al.  Visual evoked potentials after photostress in insulin-dependent diabetic patients with or without retinopathy , 1994, Graefe's Archive for Clinical and Experimental Ophthalmology.

[26]  R. Janzer The blood-brain barrier: Cellular basis , 1993, Journal of Inherited Metabolic Disease.

[27]  R. Frank,et al.  Cerebral cortical capillary basement membrane thickening in galactosaemic rats , 1987, Diabetologia.

[28]  Circulatory parameters of the retina in patients with lacunar stroke , 1986, Journal of Neurology.

[29]  M. A. Bell,et al.  Morphometric comparison of hippocampal microvasculature in ageing and demented people: Diameters and densities , 1981, Acta Neuropathologica.

[30]  D. Bracher,et al.  Measurement of vessel width on fundus photographs , 1979, Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie.

[31]  E. Kohner,et al.  Retinal vessel measurement: comparison between observer and computer driven methods , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[32]  Ronald Klein,et al.  The epidemiology of age-related macular degeneration. , 2004, American journal of ophthalmology.

[33]  Edith Hamel,et al.  Cholinergic modulation of the cortical microvascular bed. , 2004, Progress in brain research.

[34]  Ronald Klein,et al.  The relation of retinal vessel caliber to the incidence and progression of diabetic retinopathy: XIX: the Wisconsin Epidemiologic Study of Diabetic Retinopathy. , 2004, Archives of ophthalmology.

[35]  H. Hendrie,et al.  The Dementing Disorders , 2004, Psychiatric Quarterly.

[36]  L. Edvinsson,et al.  Peptidergic innervation of the cerebral circulation. Role in subarachnoid hemorrhage in man , 2004, Neurosurgical Review.

[37]  A. Bill,et al.  Aspects of oxygen and glucose consumption in the retina: Effects of high intraocular pressure and light , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[38]  D. Leys,et al.  Systemic vascular smooth muscle cell impairment in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy , 2004, Acta Neuropathologica.

[39]  V. Fischer,et al.  Altered angioarchitecture in selected areas of brains with Alzheimer's disease , 2004, Acta Neuropathologica.

[40]  C. Nordborg,et al.  Cerebral microangiopathy in stroke-prone spontaneously hypertensive rats , 2004, Acta Neuropathologica.

[41]  S. Hori,et al.  Cerebral lesions in rats with streptozotocin-induced diabetes , 2004, Acta Neuropathologica.

[42]  R. Klein,et al.  Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people. , 2004, Neurology.

[43]  O. Wiestler,et al.  Vascular Pathology in Alzheimer Disease: Correlation of Cerebral Amyloid Angiopathy and Arteriosclerosis/Lipohyalinosis with Cognitive Decline , 2003, Journal of neuropathology and experimental neurology.

[44]  L. Schmetterer,et al.  Effects of sildenafil on retinal blood flow and flicker-induced retinal vasodilatation in healthy subjects. , 2003, Investigative ophthalmology & visual science.

[45]  William J Powers,et al.  The use of positron emission tomography in cerebrovascular disease. , 2003, Neuroimaging clinics of North America.

[46]  S. Noy,et al.  The Role of Cardiovascular Risk Factors in Alzheimer's Disease , 2003, CNS Spectrums.

[47]  Jun Hatazawa,et al.  Heterogeneity of cerebral blood flow in Alzheimer disease and vascular dementia. , 2003, AJNR. American journal of neuroradiology.

[48]  E. Tsilibary Microvascular basement membranes in diabetes mellitus , 2003, The Journal of pathology.

[49]  H. Fukuyama,et al.  Central Retinal Artery Doppler Flow Parameters Reflect the Severity of Cerebral Small-Vessel Disease , 2003, Stroke.

[50]  A. Vorbrodt,et al.  Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist’s view , 2003, Brain Research Reviews.

[51]  R. Klein,et al.  Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case-control study. , 2003, Ophthalmology.

[52]  Robert M. Kessler,et al.  Imaging methods for evaluating brain function in man , 2003, Neurobiology of Aging.

[53]  G. Román,et al.  Vascular Dementia: Distinguishing Characteristics, Treatment, and Prevention , 2003, Journal of the American Geriatrics Society.

[54]  R. Klein,et al.  The prevalence and risk factors of retinal microvascular abnormalities in older persons: The Cardiovascular Health Study. , 2003, Ophthalmology.

[55]  Dao-Yi Yu,et al.  Isolated preparations of ocular vasculature and their applications in ophthalmic research , 2003, Progress in Retinal and Eye Research.

[56]  A. Yoshida,et al.  Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrument. , 2003, American journal of ophthalmology.

[57]  P. Massin,et al.  Hereditary infantile hemiparesis, retinal arteriolar tortuosity, and leukoencephalopathy , 2003, Neurology.

[58]  M. Dichgans A new cause of hereditary small vessel disease , 2003, Neurology.

[59]  J. Flanagan,et al.  Variability and repeatability of retinal blood flow measurements using the Canon Laser Blood Flowmeter. , 2002, Microvascular research.

[60]  P. Grammas,et al.  Retinal endothelial cells are more susceptible to oxidative stress and increased permeability than brain-derived endothelial cells. , 2003, Microvascular research.

[61]  L. Schmetterer,et al.  Effects of dopamine on human retinal vessel diameter and its modulation during flicker stimulation. , 2003, American journal of physiology. Heart and circulatory physiology.

[62]  I. Deary,et al.  Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia. , 2003, Diabetes.

[63]  L. Sobrevia,et al.  Regulation of amino acid and glucose transporters in endothelial and smooth muscle cells. , 2003, Physiological reviews.

[64]  G. Lammie,et al.  Hypertensive cerebral small vessel disease and stroke. , 2006, Brain pathology.

[65]  D. S. Mcleod,et al.  Astrocyte-endothelial Interactions During Human Retinal Vasculogenesis , 2002 .

[66]  R. Klein,et al.  Is early age-related maculopathy related to cognitive function? The Atherosclerosis Risk in Communities Study. , 2002, American journal of ophthalmology.

[67]  J. Stam,et al.  Retinal arterial changes correlate with cerebral small-vessel disease , 2002, Neurology.

[68]  RikiOkeda,et al.  Arterial Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Relation to Pathogenesis of Diffuse Myelin Loss of Cerebral White Matter , 2002 .

[69]  H. Grossniklaus Cerebral white matter lesions, retinopathy, and incident clinical stroke. Wong TY,∗ Klein R, Sharrett AR, Couper DJ, Klein BEK, Liao DP, Hubbard LD, Mosley TH, for the ARIC investigators. JAMA 2002;288:67–74 , 2002 .

[70]  K. Arima,et al.  Arterial Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Relation to Pathogenesis of Diffuse Myelin Loss of Cerebral White Matter: Examination of Cerebral Medullary Arteries by Reconstruction of Serial Sections of an Autopsy Case , 2002, Stroke.

[71]  H. Chui,et al.  Subcortical ischaemic vascular dementia , 2002, The Lancet Neurology.

[72]  Martin Friedlander,et al.  Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion. , 2002, Investigative ophthalmology & visual science.

[73]  M. Booth,et al.  Comparison of two grading methods to evaluate focal narrowing of retinal arterioles in glaucoma , 2002, Graefe's Archive for Clinical and Experimental Ophthalmology.

[74]  Shankar M. Krishnan,et al.  Detection and measurement of retinal vessels in fundus images using amplitude modified second-order Gaussian filter , 2002, IEEE Transactions on Biomedical Engineering.

[75]  N. Chapman,et al.  Peripheral vascular disease is associated with abnormal arteriolar diameter relationships at bifurcations in the human retina. , 2002, Clinical science.

[76]  R. Dermietzel,et al.  Angiogenesis of the blood‐brain barrier in vitro and the function of cerebral pericytes , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[77]  R. Klein,et al.  Cerebral white matter lesions, retinopathy, and incident clinical stroke. , 2002, JAMA.

[78]  M. Pache,et al.  Reproduzierbarkeit der Messungen mit dem Retinal Vessel Analyzer unter Optimalbedingungen , 2002 .

[79]  John Ludbrook,et al.  Statistical Techniques For Comparing Measurers And Methods Of Measurement: A Critical Review , 2002, Clinical and experimental pharmacology & physiology.

[80]  Paul Mitchell,et al.  Reliability of computer‐assisted retinal vessel measurement in a population , 2002, Clinical & experimental ophthalmology.

[81]  R. Klein,et al.  Retinal Microvascular Abnormalities and Cognitive Impairment in Middle-Aged Persons: The Atherosclerosis Risk in Communities Study , 2002, Stroke.

[82]  Hartwig Wolburg,et al.  Tight junctions of the blood-brain barrier: development, composition and regulation. , 2002, Vascular pharmacology.

[83]  Lorri A. Lee,et al.  Cerebral blood flow and vascular physiology. , 2002, Anesthesiology clinics of North America.

[84]  Dao-Yi Yu,et al.  Intraretinal oxygen consumption in the rat in vivo. , 2002, Investigative ophthalmology & visual science.

[85]  M. Boulton,et al.  The pathogenesis of diabetic retinopathy: old concepts and new questions , 2002, Eye.

[86]  T. Hammeke,et al.  Functional Neuroimaging in Neurology and Psychiatry , 2002, CNS Spectrums.

[87]  H J Testa,et al.  Diagnostic patterns of regional atrophy on MRI and regional cerebral blood flow change on SPECT in young onset patients with Alzheimer's disease, frontotemporal dementia and vascular dementia , 2002, Acta neurologica Scandinavica.

[88]  S. Hosking,et al.  Effect of senescence on ocular blood flow in the retina, neuroretinal rim and lamina cribrosa, using scanning laser Doppler flowmetry , 2002, Eye.

[89]  D. Tomassoni,et al.  QUANTITATIVE IMAGE ANALYSIS OF CHOROID AND RETINAL VASCULATURE IN SHR: A MODEL OF CEREBROVASCULAR HYPERTENSIVE CHANGES? , 2002, Clinical and experimental hypertension.

[90]  Leopold Schmetterer,et al.  Calculation of the diameter of the central retinal artery from noninvasive measurements in humans , 2002, Current eye research.

[91]  T. Sugiyama,et al.  Effects of caffeine on microcirculation of the human ocular fundus. , 2001, Japanese journal of ophthalmology.

[92]  Tien Yin Wong,et al.  Reliability of retinal photography in the assessment of retinal microvascular characteristics: the Atherosclerosis Risk in Communities Study. , 2002, American journal of ophthalmology.

[93]  K. Jellinger Vascular-ischemic dementia: an update. , 2002, Journal of neural transmission. Supplementum.

[94]  W Vilser,et al.  RETINAL VESSEL ANALYSIS - NEW POSSIBILITIES , 2002, Biomedizinische Technik. Biomedical engineering.

[95]  J. Flammer,et al.  [Reproducibility of measurements with the retinal vessel analyzer under optimal conditions]. , 2002, Klinische Monatsblatter fur Augenheilkunde.

[96]  B.-U. Seifert,et al.  RETINAL VESSEL ANALYZER (RVA) - DESIGN AND FUNCTION , 2002, Biomedizinische Technik. Biomedical engineering.

[97]  A. Olson,et al.  Differential glucose uptake in retina- and brain-derived endothelial cells. , 2001, Microvascular research.

[98]  L. Schmetterer,et al.  Effect of endothelin and BQ123 on ocular blood flow parameters in healthy subjects. , 2001, Investigative ophthalmology & visual science.

[99]  R. Klein,et al.  Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study , 2001, The Lancet.

[100]  F. Pierelli,et al.  Morphological and functional retinal impairment in Alzheimer's disease patients , 2001, Clinical Neurophysiology.

[101]  P. Luiten,et al.  Cerebral microvascular pathology in aging and Alzheimer's disease , 2001, Progress in Neurobiology.

[102]  N. Freimer,et al.  Hereditary vascular retinopathy, cerebroretinal vasculopathy, and hereditary endotheliopathy with retinopathy, nephropathy, and stroke map to a single locus on chromosome 3p21.1-p21.3. , 2001, American journal of human genetics.

[103]  R. Klein,et al.  Retinal microvascular abnormalities and their relationship with hypertension, cardiovascular disease, and mortality. , 2001, Survey of ophthalmology.

[104]  D O Slosman,et al.  (133)Xe SPECT cerebral blood flow study in a healthy population: determination of T-scores. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[105]  S. Cringle,et al.  Comparison of the vasoactive effects of the docosanoid unoprostone and selected prostanoids on isolated perfused retinal arterioles. , 2001, Investigative ophthalmology & visual science.

[106]  S. Galetta,et al.  Retinal findings in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (cadasil). , 2001, Survey of ophthalmology.

[107]  Dao-Yi Yu,et al.  Oxygen Distribution and Consumption within the Retina in Vascularised and Avascular Retinas and in Animal Models of Retinal Disease , 2001, Progress in Retinal and Eye Research.

[108]  P. Luiten,et al.  Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain , 2001, Neurobiology of Aging.

[109]  T. Chan-Ling,et al.  Immunolocalization of occludin and claudin-1 to tight junctions in intact CNS vessels of mammalian retina , 2001, Journal of neurocytology.

[110]  Ian G. McKeith,et al.  Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales , 2001, The Lancet.

[111]  A. Folsom,et al.  Cardiovascular risk factors and cognitive decline in middle-aged adults , 2001, Neurology.

[112]  A. Bharath,et al.  Computer algorithms for the automated measurement of retinal arteriolar diameters , 2001, The British journal of ophthalmology.

[113]  E. Fuchs,et al.  Capillary changes in hippocampal CA1 and CA3 areas of the aging rhesus monkey , 2000, Acta Neuropathologica.

[114]  W. Vilser,et al.  Dilatation großer Netzhautgefäße nach Intraokulardrucksteigerung , 2000, Der Ophthalmologe.

[115]  W Vilser,et al.  [Dilatation of large retinal vessels after increased intraocular pressure]. , 2000, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

[116]  P. Mestres,et al.  Cerebroretinal vasculopathy and leukoencephalopathy mimicking a brain tumor. Report of two early-onset cases with Fanconi's anemia-like phenotypes suggesting an autosomal-recessive inheritance pattern. , 2000, Clinical neuropathology.

[117]  O Findl,et al.  Evaluation of the Zeiss retinal vessel analyser , 2000, The British journal of ophthalmology.

[118]  J. Tang,et al.  Retina accumulates more glucose than does the embryologically similar cerebral cortex in diabetic rats , 2000, Diabetologia.

[119]  C. Delaey,et al.  Regulatory Mechanisms in the Retinal and Choroidal Circulation , 2000, Ophthalmic Research.

[120]  Xiaohong W. Gao,et al.  Quantification and characterisation of arteries in retinal images , 2000, Comput. Methods Programs Biomed..

[121]  T. Gardner,et al.  Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group. , 2000, Investigative ophthalmology & visual science.

[122]  X. Tong,et al.  Basal forebrain nitric oxide synthase (NOS)‐containing neurons project to microvessels and NOS neurons in the rat neocortex: cellular basis for cortical blood flow regulation , 2000, The European journal of neuroscience.

[123]  C. Delaey,et al.  Pressure-induced myogenic responses in isolated bovine retinal arteries. , 2000, Investigative ophthalmology & visual science.

[124]  F. Ismail-Beigi,et al.  Diabetes downregulates GLUT1 expression in the retina and its microvessels but not in the cerebral cortex or its microvessels. , 2000, Diabetes.

[125]  W. Feiden,et al.  Cerebroretinal vasculopathy mimicking a brain tumor. , 2000, Neurology.

[126]  W. Thomas,et al.  Cellular mechanisms of CNS pericytes , 2000, Brain Research Bulletin.

[127]  T. del Ser,et al.  Subcortical Vascular Dementia as a Specific Target for Clinical Trials , 2000, Annals of the New York Academy of Sciences.

[128]  T. Chan-Ling,et al.  Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. , 2000, Investigative ophthalmology & visual science.

[129]  F. Chapon,et al.  The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients. , 2000, The Journal of clinical investigation.

[130]  M. Wolzt,et al.  Endothelin-1 contributes to hyperoxia-induced vasoconstriction in the human retina. , 2000, Investigative ophthalmology & visual science.

[131]  A.D. Hoover,et al.  Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response , 2000, IEEE Transactions on Medical Imaging.

[132]  G C Roman,et al.  Research criteria for subcortical vascular dementia in clinical trials. , 2000, Journal of neural transmission. Supplementum.

[133]  D. Hirst,et al.  Retinal pericytes control expression of nitric oxide synthase and endothelin-1 in microvascular endothelial cells. , 2000, Microvascular research.

[134]  R. Klein,et al.  Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study. , 1999, Ophthalmology.

[135]  W. Thomas,et al.  Brain macrophages: on the role of pericytes and perivascular cells , 1999, Brain Research Reviews.

[136]  A. Hofman,et al.  Is age-related maculopathy associated with Alzheimer's Disease? The Rotterdam Study. , 1999, American journal of epidemiology.

[137]  E. Mackenzie,et al.  Neurochemical stimulation of the rat substantia innominata increases cerebral blood flow (but not glucose use) through the parallel activation of cholinergic and non-cholinergic pathways , 1999, Brain Research.

[138]  N C Andreasen,et al.  Age-related changes in regional cerebral blood flow among young to mid-life adults. , 1999, Neuroreport.

[139]  G. Crelier,et al.  Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[140]  C. Sinthanayothin,et al.  Automated localisation of the optic disc, fovea, and retinal blood vessels from digital colour fundus images , 1999, The British journal of ophthalmology.

[141]  G. Reifenberger,et al.  Cerebroretinal vasculopathy mimicking a brain tumor: A case of a rare hereditary syndrome , 1999, Neurology.

[142]  R. Klein,et al.  Retinal arteriolar diameters and elevated blood pressure: the Atherosclerosis Risk in Communities Study. , 1999, American journal of epidemiology.

[143]  K. Furuuchi,et al.  Glial cell line-derived neurotrophic factor induces barrier function of endothelial cells forming the blood-brain barrier. , 1999, Biochemical and biophysical research communications.

[144]  S. Tsukita,et al.  Occludin and claudins in tight-junction strands: leading or supporting players? , 1999, Trends in cell biology.

[145]  J. Rizzo,et al.  Regulation of retinal and optic nerve blood flow. , 1999, Archives of ophthalmology.

[146]  David L. Thomas,et al.  Measuring Cerebral Blood Flow Using Magnetic Resonance Imaging Techniques , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[147]  S. Jander,et al.  The role of microglia and macrophages in the pathophysiology of the CNS , 1999, Progress in Neurobiology.

[148]  F. Ismail-Beigi,et al.  Glut1 and glut3 expression, but not capillary density, is increased by cobalt chloride in rat cerebrum and retina. , 1999, Brain research. Molecular brain research.

[149]  J. Tarbell,et al.  Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. , 1998, Diabetes.

[150]  M. Dichgans,et al.  The phenotypic spectrum of CADASIL: Clinical findings in 102 cases , 1998, Annals of neurology.

[151]  P. Sternberg,et al.  Inherited retinal arteriolar tortuosity with retinal hemorrhages. , 1998, Archives of ophthalmology.

[152]  E. Dejana,et al.  Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration , 1998, The Journal of cell biology.

[153]  A. Hofman,et al.  Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study , 1998, The Lancet.

[154]  H. Breiteneder,et al.  Molecular and Immunological Characteristics of Latex Allergens , 1998, International Archives of Allergy and Immunology.

[155]  R Mielke,et al.  Positron emission tomography for diagnosis of Alzheimer's disease and vascular dementia. , 1998, Journal of neural transmission. Supplementum.

[156]  G. Ripandelli,et al.  Optical coherence tomography. , 1998, Seminars in ophthalmology.

[157]  M. Daemen,et al.  Systemic small-vessel disease is not exclusively related to lacunar stroke. A pilot study. , 1998, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[158]  J. J. Wang,et al.  Retinopathy in older persons without diabetes and its relationship to hypertension. , 1998, Archives of ophthalmology.

[159]  A. Bill,et al.  The role of nitric oxide in hyperaemic response to flicker in the retina and optic nerve in cats. , 2009, Acta ophthalmologica Scandinavica.

[160]  A. Stanton,et al.  Retinal vascular network architecture in low‐birth‐weight men , 1997, Journal of hypertension.

[161]  S. Nelson,et al.  Hereditary endotheliopathy with retinopathy, nephropathy, and stroke(HERNS) , 1997, Neurology.

[162]  M. Limburg,et al.  Impairment of Cerebrovascular Reactivity in Long-Term Type 1 Diabetes , 1997, Diabetes.

[163]  R. Klein,et al.  The relation of cardiovascular disease and its risk factors to the 5-year incidence of age-related maculopathy: the Beaver Dam Eye Study. , 1997, Ophthalmology.

[164]  H. Bokura,et al.  Subcortical silent brain infarction as a risk factor for clinical stroke. , 1997, Stroke.

[165]  A. Barber,et al.  Astrocytes increase barrier properties and ZO-1 expression in retinal vascular endothelial cells. , 1997, Investigative ophthalmology & visual science.

[166]  K. Arima,et al.  [Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy--report of an autopsied Japanese case]. , 1997, Rinsho shinkeigaku = Clinical neurology.

[167]  D. Reboussin,et al.  Cerebral Microvascular Alterations in Aging, Leukoaraiosis, and Alzheimer's Disease a , 1997, Annals of the New York Academy of Sciences.

[168]  J. Stone,et al.  Role of astrocytes in the control of developing retinal vessels. , 1997, Investigative ophthalmology & visual science.

[169]  M. Wolzt,et al.  Characterization of angiotensin-II effects on cerebral and ocular circulation by noninvasive methods. , 1997, British journal of clinical pharmacology.

[170]  W. Risau,et al.  Mechanisms of angiogenesis , 1997, Nature.

[171]  A. Mooradian Central nervous system complications of diabetes mellitus — a perspective from the blood–brain barrier , 1997, Brain Research Reviews.

[172]  F. Gustafsson Hypertensive arteriolar necrosis revisited. , 1997, Blood pressure.

[173]  P. Hardy,et al.  Control of cerebral and ocular blood flow autoregulation in neonates. , 1997, Pediatric clinics of North America.

[174]  Hiroshi Yamamoto,et al.  Induction of various blood‐brain barrier properties in non‐neural endothelial cells by close apposition to co‐cultured astrocytes , 1997, Glia.

[175]  寒河江純平,et al.  [CADASIL (Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)]. , 1997, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[176]  E. Maiorano,et al.  Ultrastructural and morphometric investigation of human brain capillaries in normal and peritumoral tissues. , 1997, Ultrastructural pathology.

[177]  J. Firth,et al.  Pressure-induced myogenic responses in human isolated cerebral resistance arteries. , 1996, Stroke.

[178]  A. Bonev,et al.  Gender differences in coronary artery diameter involve estrogen, nitric oxide, and Ca(2+)-dependent K+ channels. , 1996, Circulation research.

[179]  J. Weissenbach,et al.  Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia , 1996, Nature.

[180]  P J Whitehouse,et al.  Evaluation of dementia. , 1996, The New England journal of medicine.

[181]  A. Hughes,et al.  Arteriolar length-diameter (L:D) ratio: a geometric parameter of the retinal vasculature diagnostic of hypertension. , 1996, Journal of human hypertension.

[182]  Stephen J. Aldington,et al.  The accurate assessment of changes in retinal vessel diameter using multiple frame electrocardiograph synchronised fundus photography. , 1996, Current eye research.

[183]  P. Luiten,et al.  Ultrastructural localization of cholinergic muscarinic receptors in rat brain cortical capillaries , 1996, Brain Research.

[184]  R. Blanks,et al.  Retinal pathology in Alzheimer's disease. II. Regional neuron loss and glial changes in GCL , 1996, Neurobiology of Aging.

[185]  K. Yano,et al.  Age-related changes in stroke risk in men with hypertension and normal blood pressure. , 1996, Stroke.

[186]  R. Blanks,et al.  Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina , 1996, Neurobiology of Aging.

[187]  G. Alexander,et al.  The Metabolic Topography of Normal Aging , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[188]  E. Kohner,et al.  Regional retinal blood flow and vascular autoregulation , 1996, Eye.

[189]  S Gordon,et al.  Involvement of specific macrophage-lineage cells surrounding arterioles in barrier and scavenger function in brain cortex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[190]  T. Kern,et al.  Capillary lesions develop in retina rather than cerebral cortex in diabetes and experimental galactosemia. , 1996, Archives of ophthalmology.

[191]  D Kromhout,et al.  Twenty-five-year prediction of stroke deaths in the seven countries study: the role of blood pressure and its changes. , 1996, Stroke.

[192]  M. Araie,et al.  Time-course of changes in nicardipine effects on microcirculation in retina and optic nerve head in living rabbit eyes. , 1996, Japanese journal of ophthalmology.

[193]  G. Michelson,et al.  Influence of age on retinal and optic nerve head blood circulation. , 1996, Ophthalmology.

[194]  F. Joó Endothelial cells of the brain and other organ systems: Some similarities and differences , 1996, Progress in Neurobiology.

[195]  D. C. Wu,et al.  Retinal blood vessel width measured on color fundus photographs by image analysis. , 2009, Acta ophthalmologica Scandinavica. Supplement.

[196]  D. Kromhout Cholesterol, diastolic blood pressure, and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts , 1995, The Lancet.

[197]  B. Wasan,et al.  Vascular network changes in the retina with age and hypertension , 1995, Journal of hypertension.

[198]  C. Iadecola,et al.  Role of nitric oxide and acetylcholine in neocortical hyperemia elicited by basal forebrain stimulation: Evidence for an involvement of endothelial nitric oxide , 1995, Neuroscience.

[199]  M. O’Donnell,et al.  Astroglial cell-induced expression of Na-K-Cl cotransporter in brain microvascular endothelial cells. , 1995, The American journal of physiology.

[200]  K Münch,et al.  [Adaptive algorithm for automatic measurement of retinal vascular diameter]. , 1995, Biomedizinische Technik. Biomedical engineering.

[201]  P. Gregson,et al.  Automated grading of venous beading. , 1995, Computers and biomedical research, an international journal.

[202]  W. Pardridge Transport of small molecules through the blood-brain barrier: biology and methodology. , 1995, Advanced drug delivery reviews.

[203]  W. Jagust,et al.  Reduced Temporal Lobe Glucose Metabolism in Aging , 1995, Journal of neuroimaging : official journal of the American Society of Neuroimaging.

[204]  M. Pollay The Blood-Brain Barrier Cellular and Molecular Biology , 1995 .

[205]  A. Stanton,et al.  A method of quantifying retinal microvascular alterations associated with blood pressure and age , 1995, Journal of hypertension.

[206]  T. Williamson,et al.  Influence of age, systemic blood pressure, smoking, and blood viscosity on orbital blood velocities. , 1995, The British journal of ophthalmology.

[207]  W. Vilser,et al.  Adaptive Algorithmen zur automatischen Messung retinaler Gefäßdurchmesser - Adaptive Algorithms for the Automatic Measurement of Retinal Vessel Diameters , 1995 .

[208]  T. Takenaka,et al.  Peptidergic innervation in , 1995 .

[209]  M. Tso,et al.  Immunoreactivity against tau, amyloid precursor protein, and beta-amyloid in the human retina. , 1995, Investigative ophthalmology & visual science.

[210]  A Hofman,et al.  Epidemiology of age-related maculopathy. , 1995, Epidemiologic reviews.

[211]  Dao-Yi Yu,et al.  Intraretinal oxygen distribution in rats as a function of systemic blood pressure. , 1994, The American journal of physiology.

[212]  P. Luiten,et al.  Cerebrovascular, Neuronal, and Behavioral Effects of Long‐Term Ca2+ Channel Blockade in Aging Normotensive and Hypertensive Rat Strains , 1994, Annals of the New York Academy of Sciences.

[213]  Evidence by magnetic resonance imaging of cerebral alterations of atrophy type in young insulin-dependent diabetic patients , 1994, Journal of endocrinological investigation.

[214]  T. Sano,et al.  [Relationship of fundus oculi changes to declines in mental and physical health conditions among elderly living in a rural community]. , 1994, [Nihon koshu eisei zasshi] Japanese journal of public health.

[215]  E M Kohner,et al.  Accurate vessel width measurement from fundus photographs: a new concept. , 1994, The British journal of ophthalmology.

[216]  M. Dehouck,et al.  Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes , 1987, The Journal of cell biology.

[217]  T. Kern,et al.  Abnormalities of retinal metabolism in diabetes or galactosemia. II. Comparison of gamma-glutamyl transpeptidase in retina and cerebral cortex, and effects of antioxidant therapy. , 1994, Current eye research.

[218]  E. Kohner,et al.  Vessel diameter changes during the cardiac cycle , 1994, Eye.

[219]  J. Holash,et al.  The relationship of astrocyte-like cells to the vessels that contribute to the blood-ocular barriers , 1993, Brain Research.

[220]  T. Lüscher,et al.  Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: role of nitric oxide and endothelins. , 1993, Investigative ophthalmology & visual science.

[221]  R. Schneider,et al.  Lacunar Infarcts and White Matter Attenuation Ophthalmologic and Microcirculatory Aspects of the Pathophysiology , 1993, Stroke.

[222]  C. Riva,et al.  Effect of aging on retinal macular microcirculation: a blue field simulation study. , 1993, Investigative ophthalmology & visual science.

[223]  S. Bursell,et al.  Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. , 1993, The American journal of physiology.

[224]  J. Berman,et al.  Human fetal astrocytes induce the expression of blood-brain barrier specific proteins by autologous endothelial cells , 1993, Brain Research.

[225]  J V Arnold,et al.  Possible errors in the measurement of retinal lesions. , 1993, Investigative ophthalmology & visual science.

[226]  J. Meyer,et al.  Leuko-araiosis and cerebral perfusion in normal aging. , 1993, Experimental aging research.

[227]  M. A. Bell,et al.  Microvascular Density of the Human Paraventricular Nucleus Decreases with Aging but Not Hypertension , 1993, Experimental Neurology.

[228]  Y. Hamada [Ophthalmological study of the M-strain stroke-prone spontaneously hypertensive rats (2). Retinal arteriolar changes in fluorescein angiogram]. , 1993, Nippon Ganka Gakkai zasshi.

[229]  D. Healy,et al.  Localization of immunoreactive glutamyl aminopeptidase in rat brain. I. Association with cerebral microvessels , 1993, Brain Research.

[230]  D. Healy,et al.  Localization of immunoreactive glutamyl aminopeptidase in rat brain. II. Distribution and correlation with angiotensin II , 1993, Brain Research.

[231]  R. Klein,et al.  The relationship of cardiovascular disease and its risk factors to age-related maculopathy. The Beaver Dam Eye Study. , 1993, Ophthalmology.

[232]  H. Lassmann,et al.  Bone marrow derived elements and resident microglia in brain inflammation , 1993, Glia.

[233]  Brett D. Thackray,et al.  Semi-automatic segmentation of vascular network images using a rotating structuring element (ROSE) with mathematical morphology and dual feature thresholding , 1993, IEEE Trans. Medical Imaging.

[234]  G Marchal,et al.  Regional cerebral oxygen consumption, blood flow, and blood volume in healthy human aging. , 1992, Archives of neurology.

[235]  I. Romero,et al.  Astrocyte‐endothelial interaction: physiology and pathology , 1992, Neuropathology and applied neurobiology.

[236]  W. Vilser,et al.  [Measuring retinal vascular diameter using the scanning laser ophthalmoscope and computer. Initial results]. , 1992, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

[237]  Yuko Sato,et al.  Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain , 1992, Neuroscience Research.

[238]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[239]  O. Inanami,et al.  Nitric oxide (NO) is involved in increased cerebral cortical blood flow following stimulation of the nucleus basalis of Meynert in anesthetized rats , 1992, Neuroscience Letters.

[240]  H. Lassmann,et al.  Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras , 1992, Journal of neuropathology and experimental neurology.

[241]  J. Penn,et al.  Computerized digital image analysis of retinal vessel density: application to normoxic and hyperoxic rearing of the newborn rat. , 1992, Experimental eye research.

[242]  H. Brody,et al.  The aging brain , 1992, Acta neurologica Scandinavica. Supplementum.

[243]  W. Gispen,et al.  Nimodipine effects on cerebral microvessels and sciatic nerve in aging rats , 1992, Neurobiology of Aging.

[244]  W. Risau,et al.  Blood–Brain Barrier Pericytes Are the Main Source of γ‐Glutamyltranspeptidase Activity in Brain Capillaries , 1992, Journal of neurochemistry.

[245]  O. Ezaki,et al.  Ultracytochemical localization of the erythrocyte/HepG2-type glucose transporter (GLUT1) in cells of the blood-retinal barrier in the rat. , 1992, Investigative ophthalmology & visual science.

[246]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991, LEOS '92 Conference Proceedings.

[247]  Jörg Meyer,et al.  Chapter 18: Development of an in vitro cell culture system to mimic the blood-brain barrier , 1992 .

[248]  Kalaria Rn,et al.  The blood-brain barrier and cerebral microcirculation in Alzheimer disease. , 1992 .

[249]  H. Galla,et al.  Development of an in vitro cell culture system to mimic the blood-brain barrier. , 1992, Progress in brain research.

[250]  R N Kalaria,et al.  The blood-brain barrier and cerebral microcirculation in Alzheimer disease. , 1992, Cerebrovascular and brain metabolism reviews.

[251]  H. Gassen,et al.  Pericytes of the brain microvasculature express γ‐glutamyl transpeptidase , 1991 .

[252]  S. Thanos,et al.  The Relationship of Microglial Cells to Dying Neurons During Natural Neuronal Cell Death and Axotomy‐induced Degeneration of the Rat Retina , 1991, The European journal of neuroscience.

[253]  H. Galla,et al.  The Susceptibility of Cerebral Endothelial Cells to Astroglial Induction of Blood‐Brain Barrier Enzymes Depends on Their Proliferative State , 1991, Journal of neurochemistry.

[254]  James M. Anderson,et al.  The tight-junction-specific protein ZO-l is a component of the human and rat blood-brain barriers , 1991, Neuroscience Letters.

[255]  A. Mooradian,et al.  Glucose transport is reduced in the blood-brain barrier of aged rats , 1991, Brain Research.

[256]  L. Andries,et al.  Contractile responses of isolated bovine retinal microarteries to acetylcholine. , 1991, Investigative ophthalmology & visual science.

[257]  J. V. van Swieten,et al.  Periventricular lesions in the white matter on magnetic resonance imaging in the elderly. A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. , 1991, Brain : a journal of neurology.

[258]  J. Oosterhuis,et al.  A New Autosomal Dominant Vascular Retinopathy Syndrome , 1991, European journal of ophthalmology.

[259]  W. Tasman,et al.  Proliferative retinopathy: absence of white matter lesions at MR imaging. , 1991, Radiology.

[260]  A. Furuta,et al.  Medullary arteries in aging and dementia. , 1991, Stroke.

[261]  A Parving,et al.  Evidence for Diabetic Encephalopathy , 1991, Diabetic medicine : a journal of the British Diabetic Association.

[262]  H. Bauer,et al.  Glial cells and neurons induce blood-brain barrier related enzymes in cultured cerebral endothelial cells , 1991, Brain Research.

[263]  D. R. Anderson,et al.  Angiotensin II binding receptors in retinal and optic nerve head blood vessels. An autoradiographic approach. , 1991, Investigative ophthalmology & visual science.

[264]  H. Gassen,et al.  Pericytes of the brain microvasculature express gamma-glutamyl transpeptidase. , 1991, European journal of biochemistry.

[265]  M Ursino,et al.  Mechanisms of cerebral blood flow regulation. , 1991, Critical reviews in biomedical engineering.

[266]  S. Benedito,et al.  Endothelin-1-induced contraction of bovine retinal small arteries is reversible and abolished by nitrendipine. , 1991, Investigative ophthalmology & visual science.

[267]  S. Benedito,et al.  Histamine induces endothelium-dependent relaxation of bovine retinal arteries. , 1991, Investigative ophthalmology & visual science.

[268]  A. Laties,et al.  Peptidergic innervation of the retinal vasculature and optic nerve head. , 1990, Investigative ophthalmology & visual science.

[269]  L. Andries,et al.  Effects of beta-antagonists on contraction of bovine retinal microarteries in vitro. , 1990, Investigative ophthalmology & visual science.

[270]  Y. Yamori,et al.  Ultrastructural changes in cerebral pericytes and astrocytes of stroke-prone spontaneously hypertensive rats. , 1990, Stroke.

[271]  R. Frank,et al.  Pericyte coverage of retinal and cerebral capillaries. , 1990, Investigative ophthalmology & visual science.

[272]  H. Chui,et al.  Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review , 1990, Brain Research Bulletin.

[273]  P. J. Nielsen,et al.  Contractile and relaxing effects of arachidonic acid derivatives on isolated bovine retinal resistance arteries. , 1990, Experimental eye research.

[274]  Richard S. J. Frackowiak,et al.  Cerebral blood flow, blood volume and oxygen utilization. Normal values and effect of age. , 1990, Brain : a journal of neurology.

[275]  A. Jalkh,et al.  A simple device to standardize measurements of retinal structures in fundus photographs and retinal angiograms. , 1990, American journal of ophthalmology.

[276]  S. Lightman,et al.  The blood-brain interface , 1990, Eye.

[277]  A. Bill,et al.  Control of retinal and choroidal blood flow , 1990, Eye.

[278]  A. Alm,et al.  Permeability of ocular vessels and transport across the blood-retinal-barrier , 1990, Eye.

[279]  Martin A Mainster,et al.  The fractal properties of retinal vessels: Embryological and clinical implications , 1990, Eye.

[280]  P. Romano,et al.  Optic disc photogrammetry: magnification factors for eye position, centration, and ametropias, refractive and axial; and their application in the diagnosis of optic nerve hypoplasia. , 1989, Annals of ophthalmology.

[281]  S. Lightman,et al.  MICROVASCULAR PERMEABILITY IN EXPERIMENTAL DIABETES-MELLITUS IN THE ANESTHETIZED RAT - BRAIN, OPTIC-NERVE AND SCIATIC-NERVE , 1989 .

[282]  K. Fischbeck,et al.  Hereditary retinal vasculopathy with cerebral white matter lesions. , 1989, American journal of medical genetics.

[283]  V. Iragui,et al.  Abnormal pattern electroretinogram in Alzheimer's disease: Evidence for retinal ganglion cell degeneration? , 1989, Annals of neurology.

[284]  M. Barris,et al.  Abnormal pattern electroretinograms in patients with senile dementia of the alzheimer type , 1989, Annals of neurology.

[285]  W. A. Littler,et al.  USEFULNESS OF OPHTHALMOSCOPY IN MILD TO MODERATE HYPERTENSION , 1989, The Lancet.

[286]  J. Schnitzer Enzyme‐histochemical demonstration of microglial cells in the adult and postnatal rabbit retina , 1989, The Journal of comparative neurology.

[287]  O. Brinchmann‐Hansen,et al.  Reliable measurements from fundus photographs in the presence of focusing errors. , 1989, Investigative ophthalmology & visual science.

[288]  O. Inanami,et al.  Stimulation of the nucleus basalis of Meynert increases cerebral cortical blood flow in rats , 1989, Neuroscience Letters.

[289]  P. J. Nielsen,et al.  Calcium antagonist-induced relaxation of the prostaglandin-F2 alpha response of isolated calf retinal resistance arteries. , 1989, Experimental eye research.

[290]  D. R. Anderson,et al.  Biochemical evidence for cholinergic activity in retinal blood vessels. , 1989, Investigative ophthalmology & visual science.

[291]  J. Berliner,et al.  Stimulation of Glucose Analogue Uptake by Cerebral Microvessel Endothelial Cells by a Product Released by Astrocytes , 1989, Journal of neuropathology and experimental neurology.

[292]  M. Graeber,et al.  Identity of ED2‐positive perivascular cells in rat brain , 1989, Journal of neuroscience research.

[293]  M. Brightman The Anatomic Basis of the Blood-Brain Barrier , 1989 .

[294]  L. Edvinsson,et al.  Neuropeptides in the cerebral circulation. , 1989, Cerebrovascular and brain metabolism reviews.

[295]  E. Neuwelt,et al.  Implications of the Blood-Brain Barrier and Its Manipulation , 1989, Springer US.

[296]  M. Goldbaum,et al.  Detection of blood vessels in retinal images using two-dimensional matched filters. , 1989, IEEE transactions on medical imaging.

[297]  A. Mooradian Effect of aging on the blood-brain barrier , 1988, Neurobiology of Aging.

[298]  Tetsuo Hashimura,et al.  Morphological Changes of Blood Vessels in the Brain with Alzheimer's Disease , 1988 .

[299]  C. Riva,et al.  Retinal circulation during a spontaneous rise of intraocular pressure. , 1988, The British journal of ophthalmology.

[300]  J. Keunen,et al.  Carotid angiography in patients with lacunar infarction. A prospective study. , 1988, Stroke.

[301]  D. Hatchell,et al.  Measurement of retinal blood vessel width using computerized image analysis. , 1988, Investigative ophthalmology & visual science.

[302]  M. Mintun,et al.  Nonoxidative glucose consumption during focal physiologic neural activity. , 1988, Science.

[303]  L. Lanigan,et al.  Retinal circulation responses to systemic autonomic nerve stimulation , 1988, Eye.

[304]  W. Thomas,et al.  Brain macrophages: questions of origin and interrelationship , 1988, Brain Research Reviews.

[305]  J. Atkinson,et al.  Cerebroretinal vasculopathy. A new hereditary syndrome. , 1988, Ophthalmology.

[306]  Thomas We,et al.  Brain macrophages: questions of origin and interrelationship. , 1988 .

[307]  R. Shivers,et al.  Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model. , 1987, Brain research.

[308]  Z. Nagy,et al.  Tight junctions of brain endothelium in vitro are enhanced by astroglia , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[309]  P. Stewart,et al.  Pericytes in human cerebral microvasculature , 1987, The Anatomical record.

[310]  S. Lightman,et al.  Quantitative assessment of the permeability of the rat blood‐retinal barrier to small water‐soluble non‐electrolytes. , 1987, The Journal of physiology.

[311]  M. Mancini,et al.  Pericyte coverage is greater in the retinal than in the cerebral capillaries of the rat. , 1987, Investigative ophthalmology & visual science.

[312]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[313]  J. Berliner,et al.  Induction of γ-glutamyl transpeptidase in cultured cerebral endothelial cells by a product released by astrocytes , 1987, Brain Research.

[314]  J. Jakobsen,et al.  Quantitative Changes of Cerebral Neocortical Structure in Insulin-Treated Long-Term Streptozocin-lnduced Diabetes in Rats , 1987, Diabetes.

[315]  H. Vinters,et al.  A quantitative analysis of blood-brain barrier ultrastructure in the aging human. , 1987, Microvascular research.

[316]  R. Janzer,et al.  Astrocytes induce blood–brain barrier properties in endothelial cells , 1987, Nature.

[317]  W. Lee,et al.  Age-related retinal vasculopathy , 1987, Eye.

[318]  W. Kuschinsky,et al.  Interdependency of local capillary density, blood flow, and metabolism in rat brains. , 1986, The American journal of physiology.

[319]  B. Petrig,et al.  Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry. , 1986, Investigative ophthalmology & visual science.

[320]  F Shishido,et al.  Reduction in regional cerebral metabolic rate of oxygen during human aging. , 1986, Stroke.

[321]  R. Linsenmeier,et al.  Effects of light and darkness on oxygen distribution and consumption in the cat retina , 1986, The Journal of general physiology.

[322]  M. Woldenberg,et al.  Relation of branching angles to optimality for four cost principles. , 1986, Journal of theoretical biology.

[323]  D. Mann,et al.  Quantitative changes in cerebral cortical microvasculature in ageing and dementia , 1986, Neurobiology of Aging.

[324]  J. Siliciano,et al.  Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia , 1986, The Journal of cell biology.

[325]  C. Miller,et al.  Optic-nerve degeneration in Alzheimer's disease. , 1986, The New England journal of medicine.

[326]  P. Stewart,et al.  Three‐dimensional reconstruction of vesicles in endothelium of blood‐brain barrier versus highly permeable microvessels , 1986, The Anatomical record.

[327]  B. Petrig,et al.  Retinal blood flow autoregulation in response to an acute increase in blood pressure. , 1986, Investigative ophthalmology & visual science.

[328]  P. Emson,et al.  Neuropeptide Y and the ocular innervation of rat, guinea pig, cat and monkey , 1986, Neuroscience.

[329]  O. Brinchmann‐Hansen The light reflex on retinal arteries and veins. A theoretical study and a new technique for measuring width and intensity profiles across retinal vessels. , 1986, Acta ophthalmologica. Supplement.

[330]  C. Mody,et al.  Development of retinal arteriolar tortuosity in previously unaffected family members. , 1986, Transactions of the ophthalmological societies of the United Kingdom.

[331]  M. Asada,et al.  Epidemiologic studies of stroke in Shibata, a Japanese provincial city: preliminary report on risk factors for cerebral infarction. , 1985, Stroke.

[332]  B L Petrig,et al.  Blood velocity and volumetric flow rate in human retinal vessels. , 1985, Investigative ophthalmology & visual science.

[333]  M. Bradbury The blood-brain barrier. Transport across the cerebral endothelium. , 1985, Circulation research.

[334]  I. Herman,et al.  Microvascular pericytes contain muscle and nonmuscle actins , 1985, The Journal of cell biology.

[335]  A. Gjedde,et al.  Double-Tracer Study of the Fine Regional Blood—Brain Glucose Transfer in the Rat by Computer-Assisted Autoradiography , 1985, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[336]  N. Joyce,et al.  Contractile proteins in pericytes. I. Immunoperoxidase localization of tropomyosin , 1985, The Journal of cell biology.

[337]  N. Joyce,et al.  Contractile proteins in pericytes. II. Immunocytochemical evidence for the presence of two isomyosins in graded concentrations , 1985, The Journal of cell biology.

[338]  E. Cornford The blood-brain barrier, a dynamic regulatory interface , 1985 .

[339]  H. Tachibana,et al.  Changing topographic patterns of human cerebral blood flow with age measured by xenon CT. , 1984, AJR. American journal of roentgenology.

[340]  E. Barrett-Connor,et al.  Predictors of Stroke-Associated Mortality in the Elderly , 1984, Stroke.

[341]  D. Cogan,et al.  Comparison of retinal and cerebral vasculature in trypsin digest preparations. , 1984, The British journal of ophthalmology.

[342]  D E Kuhl,et al.  The effect of normal aging on patterns of local cerebral glucose utilization , 1984, Annals of neurology.

[343]  R. Frank,et al.  Aldose reductase activity in retinal and cerebral microvessels and cultured vascular cells. , 1983, Investigative ophthalmology & visual science.

[344]  G. Goldstein,et al.  Hexose transport in microvascular endothelial cells cultured from bovine retina. , 1983, Experimental eye research.

[345]  M. Tso,et al.  Pathophysiology of hypertensive retinopathy. , 1982, Ophthalmology.

[346]  S. Olesen,et al.  Electrical resistance of brain microvascular endothelium , 1982, Brain Research.

[347]  Michael E. Phelps,et al.  Effects of Human Aging on Patterns of Local Cerebral Glucose Utilization Determined by the [18F] Fluorodeoxyglucose Method , 1982, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[348]  P. Johnson,et al.  Thickened cerebral cortical capillary basement membranes in diabetics. , 1982, Archives of pathology & laboratory medicine.

[349]  M Zamir,et al.  Arterial branching in man and monkey , 1982, The Journal of general physiology.

[350]  T F Sherman,et al.  On connecting large vessels to small. The meaning of Murray's law , 1981, The Journal of general physiology.

[351]  C E Riva,et al.  Autoregulation of retinal circulation in response to decrease of perfusion pressure. , 1981, Investigative ophthalmology & visual science.

[352]  B. Burnside,et al.  Actin filaments in retinal pericytes and endothelial cells. , 1980, Investigative ophthalmology & visual science.

[353]  M Cereijido,et al.  Experimental modulation of occluding junctions in a cultured transporting epithelium , 1980, The Journal of cell biology.

[354]  M Zamir,et al.  Arterial bifurcations in the human retina , 1979, The Journal of general physiology.

[355]  A. Alm,et al.  Retinal and choroidal contribution to retinal metabolism in vivo. A study in pigs. , 1979, Acta physiologica Scandinavica.

[356]  O. Hunziker,et al.  The aging human cerebral cortex: a stereological characterization of changes in the capillary net. , 1979, Journal of gerontology.

[357]  E. Aurell,et al.  Hypertensive eye ground changes. Prevalence, relation to blood pressure and prognostic importance. The study of men born in 1913. , 2009, Acta medica Scandinavica.

[358]  J. Cunha-Vaz,et al.  Studies on retinal blood flow. I. Estimation of human retinal blood flow by slit-lamp fluorophotometry. , 1978, Archives of ophthalmology.

[359]  N. Hayakawa,et al.  A Prospective Study of Cerebrovascular Disease in Japanese Rural Communities, Akabane and Asahi: Part 1 Evaluation of Risk Factors in the Occurrence of Cerebral Hemorrhage and Thrombosis , 1976, Stroke.

[360]  M Zamir,et al.  Optimality principles in arterial branching. , 1976, Journal of theoretical biology.

[361]  G. Hutchins,et al.  Vessel Caliber and Branch‐Angle of Human Coronary Artery Branch‐Points , 1976, Circulation research.

[362]  I. Goto Pathological Studies on the Intracerebral and Retinal Arteries in Cerebrovascular and Noncerebrovascular Diseases , 1975, Stroke.

[363]  N. Aoki Epidemiological evaluation of funduscopic findings in cerebrovascular diseases. II. A multivariate analysis of funduscopic findings. , 1975, Japanese circulation journal.

[364]  B. S. Fine,et al.  Ocular pathology: A text and atlas , 1975 .

[365]  J. C. Parr,et al.  General caliber of the retinal arteries expressed as the equivalent width of the central retinal artery. , 1974, American journal of ophthalmology.

[366]  J. C. Parr,et al.  Mathematic relationships between the width of a retinal artery and the widths of its branches. , 1974, American journal of ophthalmology.

[367]  A. Alm,et al.  Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): a study with radioactively labelled microspheres including flow determinations in brain and some other tissues. , 1973, Experimental eye research.

[368]  W. Green,et al.  Familial Retinal Arteriolar Tortuosity with Retinal Hemorrhage , 1972 .

[369]  A. Alm,et al.  The oxygen supply to the retina. I. Effects of changes in intraocular and arterial blood pressures, and in arterial P O2 and P CO2 on the oxygen tension in the vitreous body of the cat. , 1972, Acta physiologica Scandinavica.

[370]  SATOSI WATANABE,et al.  Ungrammatical grammar in pattern recognition , 1971, Pattern Recognit..

[371]  G. Hill Studies on the Pathogenesis of Hypertensive Vascular Disease: Effect of High-Pressure Intra-Arterial Injections in Rats , 1970, Circulation research.

[372]  R. Drost [Autoregulation of cerebral blood flow]. , 1970, Munchener medizinische Wochenschrift.

[373]  A. Garner,et al.  Degeneration of Intramural Pericytes in Diabetic Retinopathy , 1970, British medical journal.

[374]  J. C. Parr,et al.  Comparison of methods of measuring vessel widths on retinal photographs and the effect of fluorescein injection on apparent retinal vessel calibers. , 1969, American journal of ophthalmology.

[375]  A. Burgess Objective measurements of the retinal vessels. , 1967, Annals of internal medicine.

[376]  A. Laties Central retinal artery innervation. Absence of adrenergic innervation to the intraocular branches. , 1967, Archives of ophthalmology.

[377]  F. D. de Oliveira,et al.  Pericytes in diabetic retinopathy. , 1966, The British journal of ophthalmology.

[378]  B. Ehinger Adrenergic Nerves to the Eye and to Related Structures in Man and in the Cynomolgus Monkey (Macaca Irus) , 1966 .

[379]  J. Dobree,et al.  A note on signs in the fundus oculi and arterial hypertension: conventional assessment and significance. , 1966, Bulletin of the World Health Organization.

[380]  A. Bill Autonomic nervous control of uveal blood flow. , 1962, Acta physiologica Scandinavica.

[381]  David G. Cogan,et al.  Retinal Vascular Patterns: Part II. Human Retinal Vessels Studied in Three Dimensions , 1961 .

[382]  H. P. Wagener,et al.  Classification of Retinal Lesions in the Presence of Vascular Hypertension: Report submitted to the American Ophthalmological Society by the committee on Classification of Hypertensive Disease of the Retina. , 1947, Transactions of the American Ophthalmological Society.

[383]  C. D. Murray THE PHYSIOLOGICAL PRINCIPLE OF MINIMUM WORK APPLIED TO THE ANGLE OF BRANCHING OF ARTERIES , 1926, The Journal of general physiology.

[384]  C D Murray,et al.  The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. , 1926, Proceedings of the National Academy of Sciences of the United States of America.