Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data

[1]  M. Munafo,et al.  Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case–control studies and evidence of publication bias , 2007, Molecular Psychiatry.

[2]  Se Joo Kim,et al.  Lack of Association between Polymorphisms of the Dopamine Receptor D4 and Dopamine Transporter Genes and Personality Traits in a Korean Population , 2006, Yonsei medical journal.

[3]  J. Nigg,et al.  Child ADHD and personality/temperament traits of reactive and effortful control, resiliency, and emotionality. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[4]  M. Munafo,et al.  The endophenotype concept in psychiatric genetics , 2006, Psychological Medicine.

[5]  A. Addington,et al.  Molecular genetic studies of ADHD: 1991 to 2004 , 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[6]  N. Martin,et al.  Genetic and environmental influences on extreme personality dispositions in adolescent female twins. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[7]  B. Ham,et al.  Personality, Dopamine Receptor D4 Exon III Polymorphisms, and Academic Achievement in Medical Students , 2006, Neuropsychobiology.

[8]  I. Gritsenko,et al.  [Dopamine system genes and personality traits of extraversion and novelty seeking]. , 2006, Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova.

[9]  Nobumasa Kato,et al.  Association between dopamine D4 receptor (DRD4) exon III polymorphism and Neuroticism in the Japanese population , 2006, Neuroscience Letters.

[10]  K. Kendler,et al.  A population-based twin study of the relationship between neuroticism and internalizing disorders. , 2006, The American journal of psychiatry.

[11]  P. Netter.  Dopamine challenge tests as an indicator of psychological traits , 2006, Human psychopharmacology.

[12]  J. Nigg,et al.  Temperament and developmental psychopathology. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[13]  C. Robert Cloninger,et al.  Temperament and Character in Mood Disorders: Influence of DRD4, SERTPR, TPH and MAO-A Polymorphisms , 2006, Neuropsychobiology.

[14]  J. Schinka.  Measurement scale does moderate the association between the serotonin transporter gene and trait anxiety: comments on Munafo et al , 2005, Molecular Psychiatry.

[15]  M. Munafo,et al.  The Serotonin Transporter Length Polymorphism, Neuroticism, and Depression: A Comprehensive Assessment of Association , 2005, Biological Psychiatry.

[16]  R. Ebstein,et al.  Polymorphic Markers of the Dopamine D4 Receptor Gene Promoter Region and Personality Traits in Mentally Healthy Individuals from the Russian Population , 2005, Russian Journal of Genetics.

[17]  D. Ghosh,et al.  5-HTTLPR and anxiety-related personality traits meta-analysis revisited: response to Munafo and colleagues , 2005, Molecular Psychiatry.

[18]  M. Munafo,et al.  Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Schinka , 2005, Molecular Psychiatry.

[19]  L. Peltonen,et al.  Novelty seeking: interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years , 2005, Psychiatric genetics.

[20]  J. Smoller,et al.  Molecular Genetics of Attention-Deficit/Hyperactivity Disorder , 2005, Biological Psychiatry.

[21]  M. Munafo,et al.  Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis , 2005, Molecular Psychiatry.

[22]  B. Langguth,et al.  Variation at the DRD4 promoter modulates extraversion in Caucasians , 2005, Molecular Psychiatry.

[23]  J. Viikari,et al.  Relationship between DRD4 Polymorphism and Lipid Metabolism: What Is the Role of Novelty Seeking? , 2005, Neuropsychobiology.

[24]  J. Viikari,et al.  Does the level of LDL cholesterol moderate a relationship between DRD4 and novelty seeking? , 2005, Biological Psychology.

[25]  Marcus R. Munafò,et al.  Assessing publication bias in genetic association studies: evidence from a recent meta-analysis , 2004, Psychiatry Research.

[26]  M. Munafo,et al.  Meta-analysis of genetic association studies. , 2004, Trends in genetics : TIG.

[27]  Kenneth S Kendler,et al.  Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism. , 2004, The American journal of psychiatry.

[28]  Shih-Jen Tsai,et al.  Association Study of Catechol- O-Methyltransferase Gene and Dopamine D4 Receptor Gene Polymorphisms and Personality Traits in Healthy Young Chinese Females , 2004, Neuropsychobiology.

[29]  M. Burmeister,et al.  Meta‐analysis of the association between a serotonin transporter promoter polymorphism (5‐HTTLPR) and anxiety‐related personality traits , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[30]  Z. Rónai,et al.  Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5‐HTTLPR polymorphisms , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[31]  R. Ebstein,et al.  An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits , 2004, Molecular Psychiatry.

[32]  L. Peltonen,et al.  Nature and nurture in novelty seeking , 2004, Molecular Psychiatry.

[33]  R. Busch,et al.  A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety , 2004, Molecular Psychiatry.

[34]  I. Jung,et al.  D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[35]  M. Munafo,et al.  Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis , 2003, Molecular Psychiatry.

[36]  K. Lesch,et al.  Further evidence for a modulation of Novelty Seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants , 2003, Molecular Psychiatry.

[37]  L. Peltonen,et al.  Association Between the Type 4 Dopamine Receptor Gene Polymorphism and Novelty Seeking , 2003, Psychosomatic medicine.

[38]  Seung-hyun Kim,et al.  Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population , 2003, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[39]  K. Lesch,et al.  Lack of Association between Polymorphisms of the Dopamine D4 Receptor Gene and Personality , 2003, Neuropsychobiology.

[40]  F. Crawford,et al.  DRD4 and novelty seeking: results of meta-analyses. , 2002, American journal of medical genetics.

[41]  A. Fanous,et al.  Neuroticism, major depression and gender: a population-based twin study , 2002, Psychological Medicine.

[42]  J. Ioannidis,et al.  Replication validity of genetic association studies , 2001, Nature Genetics.

[43]  L. Peltonen,et al.  No association of the −521 C/T polymorphism in the promoter of DRD4 with novelty seeking , 2001, Molecular Psychiatry.

[44]  Z. Rónai,et al.  Genotyping the ‐521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene , 2001, Electrophoresis.

[45]  G. Saucier,et al.  A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory , 2000, Clinical genetics.

[46]  K. Hornik,et al.  Non‐association of dopamine D4 and D2 receptor genes with personality in healthy individuals , 2000, Psychiatric genetics.

[47]  P. Costa,et al.  Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. , 2000, The American journal of psychiatry.

[48]  M. Gill,et al.  Novelty seeking traits and D4 dopamine receptors. , 2000, American journal of medical genetics.

[49]  K. Neiswanger,et al.  Personality traits and dopamine receptors (D2 and D4): linkage studies in families of alcoholics. , 1999, American journal of medical genetics.

[50]  S. Tomitaka,et al.  Association between novelty seeking and dopamine receptor D4 (DRD4) exon III polymorphism in Japanese subjects. , 1999, American journal of medical genetics.

[51]  M. Jarvelin,et al.  Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. , 1999, The American journal of psychiatry.

[52]  G Saucier,et al.  Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse. , 1999, American journal of medical genetics.

[53]  B. Brocke,et al.  Association between the dopamine D4 receptor (DRD4) exon III polymorphism and measures of Novelty Seeking in a German population , 1999, Molecular Psychiatry.

[54]  T. Arinami,et al.  A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia. , 1999, Biochemical and biophysical research communications.

[55]  M. Nöthen,et al.  Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors: replication tests. , 1999, American journal of medical genetics.

[56]  J. Evenden.  Impulsivity: a discussion of clinical and experimental findings , 1999, Journal of psychopharmacology.

[57]  M. Nöthen,et al.  Lack of association between dopamine D4 receptor gene and personality traits , 1998, Psychological Medicine.

[58]  J. Foreyt,et al.  D4 dopamine receptor gene exon III polymorphism and obesity risk , 1998, Eating and weight disorders : EWD.

[59]  S. Manuck,et al.  Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: a twin and genetic association study. , 1998, American journal of medical genetics.

[60]  J. Nigg,et al.  Parent personality traits and psychopathology associated with antisocial behaviors in childhood attention-deficit hyperactivity disorder. , 1998, Journal of child psychology and psychiatry, and allied disciplines.

[61]  L. Siever,et al.  D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. , 1997, American journal of human genetics.

[62]  R. Ebstein,et al.  Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of Novelty Seeking , 1997, Molecular Psychiatry.

[63]  S. Kanba,et al.  Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. , 1997, American journal of medical genetics.

[64]  A. Zonderman,et al.  No association between Novelty Seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants , 1997, Molecular Psychiatry.

[65]  M. Nöthen,et al.  Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. , 1997, The American journal of psychiatry.

[66]  P. Costa,et al.  Stability and change in personality assessment: the revised NEO Personality Inventory in the year 2000. , 1997, Journal of personality assessment.

[67]  K. Lesch,et al.  Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region , 1996, Science.

[68]  M Linnoila,et al.  The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. , 1996, Molecular psychiatry.

[69]  H. V. Van Tol,et al.  Modulation of Intracellular Cyclic AMP Levels by Different Human Dopamine D4 Receptor Variants , 1995, Journal of neurochemistry.

[70]  H. V. Van Tol,et al.  Dopamine D4 receptor repeat: analysis of different native and mutant forms of the human and rat genes. , 1994, Molecular pharmacology.

[71]  M. Owen,et al.  The genetic basis of complex human behaviors. , 1994, Science.

[72]  N. Martin,et al.  Testing a model for the genetic structure of personality: a comparison of the personality systems of Cloninger and Eysenck. , 1994, Journal of personality and social psychology.

[73]  D. Reiss,et al.  Genetic and environmental influences on depressive symptomatology in adolescence: individual differences and extreme scores. , 1993, Journal of child psychology and psychiatry, and allied disciplines.

[74]  K. Lesch,et al.  No association between dopamine D4 receptor gene exon III and –521C/T polymorphism and Novelty Seeking , 2002, Molecular Psychiatry.

[75]  R. Kittles,et al.  DRD4 promoter SNPs and gender effects on Extraversion in African Americans , 2002, Molecular Psychiatry.

[76]  C. Duijn,et al.  Epistatic effect of genes from the dopamine and serotonin systems on the temperament traits of Novelty Seeking and Harm Avoidance , 2002, Molecular Psychiatry.

[77]  S. Cichon,et al.  No association between dopamine D4 receptor gene variants and Novelty Seeking , 2002, Molecular Psychiatry.

[78]  Z. Rónai,et al.  Association between Novelty Seeking and the −521 C/T polymorphism in the promoter region of the DRD4 gene , 2001, Molecular Psychiatry.

[79]  Y. Fukumaki,et al.  Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits , 2001, Journal of Human Genetics.

[80]  T. Arinami,et al.  Identification of a polymorphism in the promoter region of DRD4associated with the human novelty seeking personality trait , 2000, Molecular Psychiatry.

[81]  D. Comings,et al.  Reward deficiency syndrome: genetic aspects of behavioral disorders. , 2000, Progress in brain research.

[82]  R. Ebstein,et al.  Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT) , 2000, Molecular Psychiatry.

[83]  E. Jönsson,et al.  Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers , 2000, European Archives of Psychiatry and Clinical Neuroscience.

[84]  R. Ebstein,et al.  Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking , 1996, Nature Genetics.

[85]  D. Murphy,et al.  Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking , 1996, Nature Genetics.

[86]  Cloninger Cr.  Discussions arising from: Cloninger, CR. A. unified biosocial theory of personality and its role in the development of anxiety states. , 1987, Psychiatric developments.

[87]  H. Eysenck,et al.  Manual of the Eysenck personality questionnaire , 1975 .