Bacterial Chemosensing: Cooperative Molecular Logic

Bacterial chemotaxis is mediated by transmembrane receptors that bind attractant and repellent chemicals and control an intracellular protein kinase. Each cell contains thousands of receptor subunits that form a tightly packed array at one pole. Recent studies of bacterial behavior have begun to reveal the molecular logic of this sensory architecture.

[1]  Sung-Hou Kim,et al.  Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor , 1999, Nature.

[2]  H. Berg,et al.  Binding of the Escherichia coli response regulator CheY to its target measured in vivo by fluorescence resonance energy transfer , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Tanvir R. Shaikh,et al.  Subunit Organization in a Soluble Complex of Tar, CheW, and CheA by Electron Microscopy* , 2002, The Journal of Biological Chemistry.

[4]  L. Itzhaki,et al.  The unfolding story of three-dimensional domain swapping. , 2003, Structure.

[5]  D E Koshland,et al.  A piston model for transmembrane signaling of the aspartate receptor. , 1999, Science.

[6]  Jason E. Gestwicki,et al.  Evolutionary Conservation of Methyl-Accepting Chemotaxis Protein Location in Bacteria andArchaea , 2000, Journal of bacteriology.

[7]  J. Stock,et al.  A receptor scaffold mediates stimulus-response coupling in bacterial chemotaxis. , 1999, Cell calcium.

[8]  L. Shapiro,et al.  Polar location of the chemoreceptor complex in the Escherichia coli cell. , 1993, Science.

[9]  J. Stock,et al.  Signal transduction: Hair brains in bacterial chemotaxis , 2000, Current Biology.

[10]  D. Koshland,et al.  Transmembrane signaling by a chimera of the Escherichia coli aspartate receptor and the human insulin receptor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[11]  J P Armitage,et al.  Localization and environmental regulation of MCP‐like proteins in Rhodobacter sphaeroides , 1999, Molecular microbiology.

[12]  J. Stock,et al.  Bacterial chemotaxis and the molecular logic of intracellular signal transduction networks. , 1991, Annual review of biophysics and biophysical chemistry.

[13]  J. S. Parkinson,et al.  Crosslinking snapshots of bacterial chemoreceptor squads , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[14]  H. Berg,et al.  Functional interactions between receptors in bacterial chemotaxis , 2004, Nature.

[15]  M. Homma,et al.  Attractant binding alters arrangement of chemoreceptor dimers within its cluster at a cell pole. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[16]  H. Berg,et al.  Localization of components of the chemotaxis machinery of Escherichia coli using fluorescent protein fusions , 2000, Molecular microbiology.

[17]  J. S. Parkinson,et al.  Collaborative signaling by mixed chemoreceptor teams in Escherichia coli , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[18]  J. Changeux,et al.  ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. , 1965, Journal of molecular biology.

[19]  J. Stock,et al.  Organization of the Receptor-Kinase Signaling Array That Regulates Escherichia coli Chemotaxis* , 2002, The Journal of Biological Chemistry.

[20]  M. Homma.  Chemoreceptor signaling involves dimer-to-dimer interaction with its cluster at a cell pole , 2004 .

[21]  J. Stock,et al.  Bacterial chemotaxis , 2003, Current Biology.