Influence of Sugar Amine Regiochemistry on Digitoxigenin Neoglycoside Anticancer Activity.
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C. Zhan | J. Thorson | Yaxia Yuan | N. Nandurkar | L. Fang | L. Ponomareva | Jianjun Zhang
[1] P. Nissen,et al. Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex , 2015, Proceedings of the National Academy of Sciences.
[2] Q. She,et al. The Identification of Perillyl Alcohol Glycosides with Improved Antiproliferative Activity , 2014, Journal of medicinal chemistry.
[3] Randal D Goff,et al. Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads. , 2014, MedChemComm.
[4] M. López-Lázaro,et al. The in vivo antitumor activity of cardiac glycosides in mice xenografted with human cancer cells is probably an experimental artifact , 2014, Oncogene.
[5] M. López-Lázaro,et al. Evaluating the Cancer Therapeutic Potential of Cardiac Glycosides , 2014, BioMed research international.
[6] J. Thorson,et al. A Simple Strategy for Glycosyltransferase‐Catalyzed Aminosugar Nucleotide Synthesis , 2014, Chembiochem : a European journal of chemical biology.
[7] C. Dinu,et al. Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation. , 2014, Biochemical pharmacology.
[8] E. Rosenthal,et al. A novel extracellular drug conjugate significantly inhibits head and neck squamous cell carcinoma. , 2013, Oral oncology.
[9] J. Thorson,et al. Synthesis and antibacterial activity of doxycycline neoglycosides. , 2013, Journal of natural products.
[10] G. Figtree,et al. Redox-dependent regulation of the Na⁺-K⁺ pump: new twists to an old target for treatment of heart failure. , 2013, Journal of molecular and cellular cardiology.
[11] P. Nissen,et al. Crystal structure of the high-affinity Na+,K+-ATPase–ouabain complex with Mg2+ bound in the cation binding site , 2013, Proceedings of the National Academy of Sciences.
[12] H. Gelderblom,et al. Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials , 2013, Investigational New Drugs.
[13] Mark S. Taylor,et al. Synthesis of cardiac glycoside analogs by catalyst-controlled, regioselective glycosylation of digitoxin. , 2013, Organic letters.
[14] L. Zitvogel,et al. Trial watch , 2013, Oncoimmunology.
[15] N. Akhmedov,et al. C3′/C4′‐Stereochemical Effects of Digitoxigenin α‐L‐/α‐D‐Glycoside in Cancer Cytotoxicity , 2013, ChemMedChem.
[16] J. Thorson,et al. Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation. , 2012, Organic letters.
[17] T. Kawabata,et al. Regioselective diversification of a cardiac glycoside, lanatoside C, by organocatalysis. , 2012, The Journal of organic chemistry.
[18] L. Zitvogel,et al. Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death , 2012, Science Translational Medicine.
[19] E. Diamandis,et al. Digitoxin-Induced Cytotoxicity in Cancer Cells Is Mediated through Distinct Kinase and Interferon Signaling Networks , 2011, Molecular Cancer Therapeutics.
[20] Y. Rojanasakul,et al. C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity. , 2011, ACS medicinal chemistry letters.
[21] Y. Rojanasakul,et al. Synthesis and Evaluation of the α-d-/α-l-Rhamnosyl and Amicetosyl Digitoxigenin Oligomers as Antitumor Agents , 2011 .
[22] Y. Rojanasakul,et al. Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell. , 2011, ACS medicinal chemistry letters.
[23] Derek K. Rogalsky,et al. A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis. , 2010, ACS medicinal chemistry letters.
[24] L. Bohlin,et al. Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs. , 2009, Journal of natural products.
[25] Eleftherios P. Diamandis,et al. Novel therapeutic applications of cardiac glycosides , 2008, Nature Reviews Drug Discovery.
[26] Robert A Newman,et al. Cardiac glycosides as novel cancer therapeutic agents. , 2008, Molecular interventions.
[27] K. Winnicka,et al. Apoptosis-mediated cytotoxicity of ouabain, digoxin and proscillaridin A in the estrogen independent MDA-MB-231 breast cancer cells , 2007, Archives of pharmacal research.
[28] R. Kiss,et al. Cardiotonic steroids on the road to anti-cancer therapy. , 2007, Biochimica et biophysica acta.
[29] Lijun Liu,et al. Identification of a Pool of Non-pumping Na/K-ATPase* , 2007, Journal of Biological Chemistry.
[30] A. Andres,et al. Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5. , 2006, Cancer research.
[31] R. Kiss,et al. Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers. , 2006, Neoplasia.
[32] Xin-Yun Huang,et al. Binding of Src to Na+/K+-ATPase forms a functional signaling complex. , 2005, Molecular biology of the cell.
[33] Zijian Xie,et al. The Na/K-ATPase-mediated signal transduction as a target for new drug development. , 2005, Frontiers in bioscience : a journal and virtual library.
[34] F. Hoffmann,et al. Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[35] Lijun Liu,et al. Digitalis-Induced Signaling by Na+/K+-ATPase in Human Breast Cancer Cells , 2005, Molecular Pharmacology.
[36] G. Bianchi,et al. Organ Hypertrophic Signaling within Caveolae Membrane Subdomains Triggered by Ouabain and Antagonized by PST 2238* , 2004, Journal of Biological Chemistry.
[37] P. S. Wang,et al. Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells. , 2001, The Journal of urology.
[38] L. Bohlin,et al. Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells , 2001, Anti-cancer drugs.
[39] Kai Simons,et al. Lipid rafts and signal transduction , 2000, Nature Reviews Molecular Cell Biology.
[40] L. Nutt,et al. Cardiac glycosides stimulate Ca2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. , 2000, Cancer research.
[41] J. Haux. Digitoxin is a potential anticancer agent for several types of cancer. , 1999, Medical hypotheses.
[42] B. Stenkvist. Is digitalis a therapy for breast carcinoma? , 1999, Oncology reports.
[43] K. Repke. Toward the discovery of digitalis derivatives with inotropic selectivity , 1997 .
[44] Abe. J. Goldin,et al. DIGITALIS AND CANCER , 1984, The Lancet.
[45] E. Bengtsson,et al. Cardiac glycosides and breast cancer, revisited. , 1982, The New England journal of medicine.
[46] G. Eklund,et al. CARDIAC GLYCOSIDES AND BREAST CANCER , 1979, The Lancet.
[47] D. Greenblatt,et al. Inotropic and Toxic Effects of a Polar Cardiac Glycoside Derivative in the Dog , 1978, Circulation research.
[48] R. Caldwell,et al. Pharmacological studies of a new 4-aminosugar cardiac glycoside (ASI-222). , 1976, The Journal of pharmacology and experimental therapeutics.
[49] Z. Braf,et al. TOXICITY OF COLLINS SOLUTION , 1974 .
[50] P. Nissen,et al. Na+,K+-ATPase as a docking station: protein–protein complexes of the Na+,K+-ATPase , 2012, Cellular and Molecular Life Sciences.
[51] Liying Wang,et al. Digitoxin and a synthetic monosaccharide analog inhibit cell viability in lung cancer cells. , 2012, Toxicology and applied pharmacology.
[52] G. O'Doherty,et al. The de novo synthesis of oligosaccharides: application to the medicinal chemistry SAR-study of digitoxin. , 2008, Current topics in medicinal chemistry.
[53] Zijian Xie,et al. The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades , 2008, Pflügers Archiv - European Journal of Physiology.