Addition of clonidine reduce dose of fentanyl and Ropivacaine in Epidural Anaesthesia

Aim of Study: To find out effect of clonidine on fentanyl and Ropivacaine requirement to produce Epidural Anesthesia. Material and Method: After Institute ethical clearance and consent from patient, 60 patients of ASA I and II were studied in 3 groups. All patients were premedicated with ranitidine and metoclopramide. In operation room epidural catheter was placed. After recording base line hemodynamic parameters, drugs were mixed in 20ml syringe according to 3 different groups and given through epidural catheter. Observation and Result: All patients were monitored for hemodynamic changes and recorded at different time interval. Data were analyzed using different tests. Patients of all 3 group have similar level of anesthesia with lower adverse effects hypotension which was more in clonidine, fentanyl and ropivacaine group. Conclusion: With this study we concluded that adition of clonidine in fentanyl and ropivacaine significantly reduces the amount of ropivacaine and fentanyl required to produce epidural anesthesia.

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