Functional magnetic resonance imaging of the lung.

Limited imaging of lung function is possible with methods that use ionizing radiation, such as computed tomography (CT) and lung scintigraphy. Methods using magnetic resonance (MR) are preferable because they do not involve ionizing radiation. At ®rst, MR methods were dif®cult because of the lack of protons and artefacts caused by inhomogeneity in the lungs. Recently, new techniques have allowed static and dynamic lung imaging with MR. We discuss the methods that allow functional imaging of the lung and describe new developments in functional MR imaging (MRI). From being almost invisible to MRI, lung images with MR may soon radically affect the way we assess the function of the lung and the pulmonary circulation.

[1]  L W Hedlund,et al.  Detection of emphysema in rat lungs by using magnetic resonance measurements of 3He diffusion. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[2]  L W Hedlund,et al.  MR microimaging of the lung using volume projection encoding , 1997, Magnetic resonance in medicine.

[3]  W. Webb,et al.  Dynamic Quantitative Computed Tomography: A Predictor of Pulmonary Function in Obstructive Lung Diseases , 1994, Investigative radiology.

[4]  Pere Casan,et al.  Use of electrical impedance tomography (EIT) for the assessment of unilateral pulmonary function , 2002, Physiological measurement.

[5]  L. Hedlund,et al.  Hyperpolarized 3He NMR Lineshape Measurements in the Live Guinea Pig Lung , 1998, Magnetic resonance in medicine.

[6]  M S Frank,et al.  CT of the lung in patients with pulmonary emphysema: diagnosis, quantification, and correlation with pathologic and physiologic findings. , 1994, AJR. American journal of roentgenology.

[7]  S. Böhm,et al.  Effects of Recruitment Maneuver on Atelectasis in Anesthetized Children , 2003, Anesthesiology.

[8]  J. Hogg Magnetic resonance imaging. , 1994, Journal of the Royal Naval Medical Service.

[9]  Burkhard Lachmann,et al.  Monitoring of recruitment and derecruitment by electrical impedance tomography in a model of acute lung injury , 2000, Critical care medicine.

[10]  E. Hoffman,et al.  CT-based assessment of regional pulmonary microvascular blood flow parameters. , 2003, Journal of applied physiology.

[11]  W. Happer,et al.  Biological magnetic resonance imaging using laser-polarized 129Xe , 1994, Nature.

[12]  M. Lipton,et al.  Upper airway obstruction in infants and children: evaluation with ultrafast CT. , 1987, Radiology.

[13]  H. Kauczor,et al.  3Helium-MRI-Based Assessment of Regional Gas Exchange Impairment during Experimental Pulmonary Artery Occlusion: [2002][A-1309] , 2002 .

[14]  P. Postmus,et al.  Evaluation of electrical impedance tomography in the measurement of PEEP-induced changes in lung volume. , 1999, Chest.

[15]  L. Hedlund,et al.  Measurements of hyperpolarized gas properties in the lung. part III: 3He T1 , 2001, Magnetic resonance in medicine.

[16]  M. Albert,et al.  Development of hyperpolarized noble gas MRI. , 1998, Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment.

[17]  A. MacKay,et al.  1H NMR measurements of wet/dry ratio and T1, T2 distributions in lung. , 1997, Journal of magnetic resonance.

[18]  M. Prokop Multislice CT angiography. , 2000, European journal of radiology.

[19]  L. Brodsky,et al.  Airway evaluation in children with use of ultrafast CT: pitfalls and recommendations. , 1991, Radiology.

[20]  K. K. Tan,et al.  In vivo PO2 imaging in the porcine model with perfluorocarbon F-19 NMR at low field. , 1996, Magnetic resonance imaging.

[21]  K. Soejima,et al.  Inhaling gas with different CT densities allows detection of abnormalities in the lung periphery of patients with smoking-induced COPD. , 2001, Chest.

[22]  P. Croisille,et al.  Lung perfusion demonstrated by contrast-enhanced dynamic magnetic resonance imaging. Application to unilateral lung transplantation. , 1997, Investigative radiology.

[23]  Alfred Kastler,et al.  Quelques suggestions concernant la production optique et la détection optique d'une inégalité de population des niveaux de quantifigation spatiale des atomes. Application à l'expérience de Stern et Gerlach et à la résonance magnétique , 1950 .

[24]  N Weiler,et al.  Quantification of regional intrapulmonary oxygen partial pressure evolution during apnea by (3)He MRI. , 1999, Journal of magnetic resonance.

[25]  M. Oudkerk,et al.  Comparison of contrast-enhanced magnetic resonance angiography and conventional pulmonary angiography for the diagnosis of pulmonary embolism: a prospective study , 2002, The Lancet.

[26]  M Thelen,et al.  Imaging of the lungs using 3he MRI: Preliminary clinical experience in 18 patients with and without lung disease , 1997, Journal of magnetic resonance imaging : JMRI.

[27]  H. Kauczor,et al.  MRI using hyperpolarized noble gases , 1998, European Radiology.

[28]  G. Mills,et al.  Unilateral magnetic stimulation of the phrenic nerve. , 1995, Thorax.

[29]  H C Charles,et al.  Cystic fibrosis: combined hyperpolarized 3He-enhanced and conventional proton MR imaging in the lung--preliminary observations. , 1999, Radiology.

[30]  Dmitriy A Yablonskiy,et al.  Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[31]  Thomas J. Gal,et al.  Nunn’s Applied Respiratory Physiology. 5th ed. , 2000 .

[32]  M. Goldman,et al.  Diaphragm function and alveolar hypoventilation. , 1976, The Quarterly journal of medicine.

[33]  R M Angus,et al.  Ultrasound assessment of normal hemidiaphragmatic movement: relation to inspiratory volume. , 1994, Thorax.

[34]  G. Guillot,et al.  CPMG measurements and ultrafast imaging in human lungs with hyperpolarized helium‐3 at low field (0.1 T) , 2002, Magnetic resonance in medicine.

[35]  H. Kauczor,et al.  Temporal dynamics of lung aeration determined by dynamic CT in a porcine model of ARDS. , 2001, British journal of anaesthesia.

[36]  J. Benditt,et al.  Variability of diaphragm structure among healthy individuals. , 1997, American journal of respiratory and critical care medicine.

[37]  Middleton,et al.  Nuclear relaxation of 3He in the presence of O2. , 1995, Physical review. A, Atomic, molecular, and optical physics.

[38]  Peter Bachert,et al.  Nuclear magnetic resonance imaging of airways in humans with use of hyperpolarized 3He , 1996, Magnetic resonance in medicine.

[39]  M. Frank,et al.  Small-airway diseases of the lungs: findings at expiratory CT. , 1994, AJR. American journal of roentgenology.

[40]  W. Webb,et al.  Normal trachea during forced expiration: dynamic CT measurements. , 1993, Radiology.

[41]  J. Houston,et al.  Comparison of ultrasound with fluoroscopy in the assessment of suspected hemidiaphragmatic movement abnormality. , 1995, Clinical radiology.

[42]  J Knight-Scott,et al.  Interleaved Echo-Planar Imaging of the Lungs with Hyperpolarized 3 , .

[43]  S. Eveloff,et al.  Diaphragm thickening during inspiration. , 1997, Journal of applied physiology.

[44]  G Gamsu,et al.  Dynamic pulmonary CT: findings in healthy adult men. , 1993, Radiology.

[45]  H. Kauczor,et al.  3He MRI in healthy volunteers: preliminary correlation with smoking history and lung volumes , 2000, NMR in biomedicine.

[46]  R. Kuzo,et al.  Subsequent pulmonary embolism: risk after a negative helical CT pulmonary angiogram--prospective comparison with scintigraphy. , 2000, Radiology.

[47]  The definition of emphysema. Report of a National Heart, Lung, and Blood Institute, Division of Lung Diseases workshop. , 1985, The American review of respiratory disease.

[48]  E J Stern,et al.  Dynamic Imaging of Lung Morphology With Ultrafast High‐Resolution Computed Tomography , 1993, Journal of thoracic imaging.

[49]  J S Leigh,et al.  Detection and localization of pulmonary air leaks using laser-polarized (3)He MRI. , 2000, Magnetic resonance in medicine.

[50]  K. Suga,et al.  Regional Lung Functional Impairment in Acute Airway Obstruction and Pulmonary Embolic Dog Models Assessed With Gadolinium-Based Aerosol Ventilation and Perfusion Magnetic Resonance Imaging , 2002, Investigative radiology.

[51]  D. Yablonskiy,et al.  Dynamic echo planar MR imaging of lung ventilation with hyperpolarized 3He in normal subjects and patients with severe emphysema , 2000, NMR in biomedicine.

[52]  J. Hajnal,et al.  Magnetic resonance imaging of lung water content and distribution in term and preterm infants. , 2002, American journal of respiratory and critical care medicine.

[53]  O. Haraldseth,et al.  Pulmonary embolism: detection with MR perfusion imaging of lung--a feasibility study. , 1997, Radiology.

[54]  J R MacFall,et al.  Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part II: T∗︁2 , 1999, Magnetic resonance in medicine.

[55]  F. Mccool,et al.  Ultrasound evaluation of the paralyzed diaphragm. , 1997, American journal of respiratory and critical care medicine.

[56]  P. Grenier,et al.  Diaphragm and chest wall: assessment of the inspiratory pump with MR imaging-preliminary observations. , 2000, Radiology.

[57]  G Gamsu,et al.  High-resolution CT of the lungs: an optimal approach. , 1987, Radiology.

[58]  D Gur,et al.  Dynamic computed tomography of the lung: regional ventilation measurements. , 1979, Journal of computer assisted tomography.

[59]  Stern Ej,et al.  Dynamic imaging of lung morphology with ultrafast high-resolution computed tomography. , 1993 .

[60]  P De Vuyst,et al.  Pulmonary emphysema: quantitative CT during expiration. , 1996, Radiology.

[61]  G J Kemerink,et al.  Reproducibility of spirometrically controlled CT lung densitometry in a clinical setting. , 1998, The European respiratory journal.

[62]  T. Mashimo,et al.  Analgesic and hypnotic effects of subanaesthetic concentrations of xenon in human volunteers: comparison with nitrous oxide. , 1995, British journal of anaesthesia.

[63]  H. Kauczor,et al.  Dynamic (19)F-MRI of pulmonary ventilation using sulfur hexafluoride (SF(6)) gas. , 2001, Magnetic resonance in medicine.

[64]  Michiyasu Suzuki,et al.  Evaluation of Cerebral Perfusion Parameters Measured by Perfusion CT in Chronic Cerebral Ischemia: Comparison With Xenon CT , 2002, Journal of computer assisted tomography.

[65]  H. Kauczor,et al.  Dynamic 19F‐MRI of pulmonary ventilation using sulfur hexafluoride (SF6) gas , 2001 .

[66]  S. Lele,et al.  Parameter estimation and confidence intervals for Xe-CT ventilation studies: a Monte Carlo approach. , 1998, Journal of applied physiology.

[67]  J. Hajnal,et al.  Investigation of Lung Disease in Preterm Infants Using Magnetic Resonance Imaging , 2000, Neonatology.

[68]  M. Reiser,et al.  MR lung imaging at 0.2 T with T1‐weighted true FISP: Native and oxygen‐enhanced , 2001, Journal of magnetic resonance imaging : JMRI.

[69]  Edwin J R van Beek,et al.  Dynamic radial projection MRI of inhaled hyperpolarized 3He gas , 2003, Magnetic resonance in medicine.

[70]  E. Otten,et al.  Interdisciplinary experiments with polarized 3He , 1998 .

[71]  Eric A. Hoffman,et al.  Automatic lung segmentation for accurate quantitation of volumetric X-ray CT images , 2001, IEEE Transactions on Medical Imaging.

[72]  P. Sonigo,et al.  Fetal lung volume measurement by magnetic resonance imaging in congenital diaphragmatic hernia , 2001, BJOG : an international journal of obstetrics and gynaecology.

[73]  B. Brown,et al.  Applied potential tomography: possible clinical applications. , 1985, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[74]  H. Kauczor,et al.  19F‐MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation , 2002, Magnetic resonance in medicine.

[75]  L W Hedlund,et al.  Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: Diffusion coefficient , 1999, Magnetic resonance in medicine.

[76]  S. C. Cullen,et al.  The anesthetic properties of xenon in animals and human beings, with additional observations on krypton. , 1951, Science.

[77]  Andrei Constantinescu,et al.  Mechanical model of the inspiratory pump. , 2002, Journal of biomechanics.

[78]  R H Smallwood,et al.  Multi-frequency imaging and modelling of respiratory related electrical impedance changes. , 1994, Physiological measurement.

[79]  M Salerno,et al.  Dynamic spiral MRI of pulmonary gas flow using hyperpolarized 3He: Preliminary studies in healthy and diseased lungs , 2001, Magnetic resonance in medicine.

[80]  H. Kauczor,et al.  MRI of the pulmonary parenchyma , 1999, European Radiology.

[81]  M. Bouchiat,et al.  Nuclear Polarization in He 3 Gas Induced by Optical Pumping and Dipolar Exchange , 1960 .

[82]  J R Galvin,et al.  Obstructive sleep apnea: diagnosis with ultrafast CT. , 1989, Radiology.

[83]  Magalie Viallon,et al.  k‐Space filtering in 2D gradient‐echo breath‐hold hyperpolarized 3He MRI: Spatial resolution and signal‐to‐noise ratio considerations , 2002, Magnetic resonance in medicine.

[84]  H. Kauczor,et al.  Functional MR imaging of pulmonary ventilation using hyperpolarized noble gases , 2000 .

[85]  J. Remy,et al.  Risk of pulmonary embolism after a negative spiral CT angiogram in patients with pulmonary disease: 1-year clinical follow-up study. , 2002, Radiology.

[86]  T A Altes,et al.  Hyperpolarized 3He MR lung ventilation imaging in asthmatics: Preliminary findings , 2001, Journal of magnetic resonance imaging : JMRI.

[87]  Gerhard Laub,et al.  Dynamic 3D MR angiography of the pulmonary arteries in under four seconds , 2001, Journal of magnetic resonance imaging : JMRI.

[88]  M Thelen,et al.  Assessment of lung volumes using helical CT at inspiration and expiration: comparison with pulmonary function tests. , 1998, AJR. American journal of roentgenology.

[89]  H. Kauczor,et al.  Dynamic computed tomography: a novel technique to study lung aeration and atelectasis formation during experimental CPR. , 2002, Resuscitation.

[90]  L. Hedlund,et al.  MR Imaging with Hyperpolarized 3He Gas , 1995, Magnetic resonance in medicine.

[91]  N Weiler,et al.  [Ultrafast MRI of lung ventilation using hyperpolarized helium-3]. , 2000, RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin.

[92]  Burkhard Lachmann,et al.  Regional pressure volume curves by electrical impedance tomography in a model of acute lung injury , 2000, Critical care medicine.

[93]  G. Guillot,et al.  Low-field 3He nuclear magnetic resonance in human lungs , 1997 .

[94]  D G Cory,et al.  Low-field MRI of laser polarized noble gas. , 1998, Physical review letters.

[95]  L. Hedlund,et al.  MR microscopy of lung airways with hyperpolarized 3He , 1998, Magnetic resonance in medicine.

[96]  D. Yablonskiy,et al.  MR imaging of diffusion of 3He gas in healthy and diseased lungs , 2000, Magnetic resonance in medicine.

[97]  Eric A Hoffman,et al.  Subsecond multisection CT of regional pulmonary ventilation. , 2002, Academic radiology.

[98]  D C Noll,et al.  MR imaging of lung parenchyma: a solution to susceptibility. , 1992, Radiology.

[99]  H. Kauczor,et al.  Analysis of intrapulmonary O(2) concentration by MR imaging of inhaled hyperpolarized helium-3. , 1999, Journal of applied physiology.

[100]  A R Sovijärvi,et al.  Quantitative functional lung imaging with synchrotron radiation using inhaled xenon as contrast agent. , 2001, Physics in medicine and biology.

[101]  Peter Herrmann,et al.  Regional Lung Perfusion as Determined by Electrical Impedance Tomography in Comparison With Electron Beam CT Imaging , 2002, IEEE Transactions on Medical Imaging.

[102]  M. Schnall,et al.  Detection and localization of pulmonary air leaks using laser‐polarized 3He MRI , 2000 .

[103]  H. Kauczor,et al.  Focal airtrapping at expiratory high-resolution CT: comparison with pulmonary function tests , 2000, European Radiology.

[104]  J. Christopher,et al.  Temporal dynamics of blood flow effects in half‐Fourier fast spin echo 1H magnetic resonance imaging of the human lungs , 2001, Journal of magnetic resonance imaging : JMRI.

[105]  Hans-Ulrich Kauczor,et al.  CT attenuation of paired HRCT scans obtained at full inspiratory/expiratory position: comparison with pulmonary function tests , 2002, European Radiology.

[106]  H. Kauczor,et al.  3He‐MRI‐based vs. conventional determination of lung volumes in patients after unilateral lung transplantation: a new approach to regional spirometry , 2002, Acta anaesthesiologica Scandinavica.

[107]  J. Benditt,et al.  Maximal inspiratory pressures and dimensions of the diaphragm. , 1997, American journal of respiratory and critical care medicine.

[108]  G. Adam,et al.  Mechanical Delivery of Aerosolized Gadolinium-DTPA for Pulmonary Ventilation Assessment in MR Imaging , 2001, Investigative radiology.

[109]  M. Deimling,et al.  Low field thoracic MRI--a fast and radiation free routine imaging modality in children. , 2001, Magnetic resonance imaging.

[110]  G. K. Walters,et al.  POLARIZATION OF He$sup 3$ GAS BY OPTICAL PUMPING , 1963 .

[111]  C. Alexander Diaphragm movements and the diagnosis of diaphragmatic paralysis. , 1966, Clinical radiology.

[112]  H. Kauczor,et al.  Dynamic Ventilation 3He-Magnetic Resonance Imaging With Lung Motion Correction: Gas Flow Distribution Analysis , 2002, Investigative radiology.

[113]  E. Miron,et al.  Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms , 1984 .

[114]  J Hildebrandt,et al.  Determination of regional ventilation and perfusion in the lung using xenon and computed tomography. , 2001, Journal of applied physiology.

[115]  E. V. van Beek,et al.  MR imaging of the lungs with hyperpolarized helium-3 gas transported by air. , 2002, Physics in medicine and biology.

[116]  J. V. van Engelshoven,et al.  Chronic obstructive pulmonary disease: evaluation with spirometrically controlled CT lung densitometry. , 1994, Radiology.

[117]  P. Grenier,et al.  Mild intermittent asthma: CT assessment of bronchial cross-sectional area and lung attenuation at controlled lung volume. , 2002, Radiology.