Viral tissue tropisms and interferon production in white leghorn chickens infected with two avian reovirus strains.

Inoculation of 6-day-old and 4-week-old chickens with pathogenic or attenuated avian reovirus resulted in an inapparent infection. The virus had a greater tissue distribution and persisted longer in tissues of 6-day-old chickens. Interferon was detected in only the serum and lung of infected chickens and appeared to be related to route of inoculation. Titers of interferon were greater and appeared sooner in the tissues of older chickens. Reovirus-neutralizing antibody was not detected in the serum of chickens of either age 120 days postinfection.

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