Epithelial-stromal interactions and tumor progression: meeting summary and future directions.

The Epithelial-Stromal Interactions Workshop was organized with the purpose of accelerating progress in understanding the interrelationship between tumor cells and their microenvironment and applying this knowledge to the control of tumor progression. The format of the meeting was the presentation of brief reports that focused on concepts rather than specifics, with extensive discussion periods to identify the issues and barriers hindering progress in this area. This report summarizes the findings of this meeting, highlighting the intimate relationship between tumor cells and their environment and addressing the opportunities that manipulation of host-tumor interactions has for therapeutic intervention. Several specific recommendations are made to advance knowledge and progress in this field.

[1]  D. Hanahan,et al.  MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis , 2000, Cell.

[2]  Shigeyoshi Itohara,et al.  Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis , 2000, Nature Cell Biology.

[3]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[4]  P. Polakis.  Wnt signaling and cancer. , 2000, Genes & development.

[5]  A. Reynolds,et al.  The p120 catenin family: complex roles in adhesion, signaling and cancer. , 2000, Journal of cell science.

[6]  E. Ruoslahti,et al.  An address system in the vasculature of normal tissues and tumors. , 2000, Annual review of immunology.

[7]  L. Matrisian,et al.  Matrix metalloproteinases: multifunctional contributors to tumor progression. , 2000, Molecular medicine today.

[8]  S. Baruchel,et al.  Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. , 2000, The Journal of clinical investigation.

[9]  Donald E. Ingber,et al.  The structural and mechanical complexity of cell-growth control , 1999, Nature Cell Biology.

[10]  I. Fidler,et al.  Critical determinants of cancer metastasis: rationale for therapy , 1999, Cancer Chemotherapy and Pharmacology.

[11]  V. Weaver,et al.  Tissue structure, nuclear organization, and gene expression in normal and malignant breast. , 1999, Cancer research.

[12]  N. Fusenig,et al.  Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes , 1998, Molecular carcinogenesis.

[13]  R. Jain.  The next frontier of molecular medicine: Delivery of therapeutics , 1998, Nature Medicine.

[14]  V. Quaranta,et al.  Integrins and laminins in tissue remodeling. , 1997, Kidney international.

[15]  A. Varki,et al.  Sialic acids as ligands in recognition phenomena , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.