Design, synthesis and structure-activity relationships of 6-O-arylpropargyl diazalides with potent activity against multidrug-resistant Streptococcus pneumoniae.

[1]  Hiroshi Ikuta,et al.  In vitro and in vivo antibacterial activities of the tricyclic ketolide TE-802 and its analogs. , 2004, The Journal of antibiotics.

[2]  M. Mitten,et al.  Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides. , 2004, Bioorganic & medicinal chemistry letters.

[3]  G. Stone,et al.  Synthesis and antibacterial activity of 6-O-arylbutynyl ketolides with improved activity against some key erythromycin-resistant pathogens. , 2003, Journal of medicinal chemistry.

[4]  Suoming Zhang,et al.  Novel erythromycin derivatives with aryl groups tethered to the C-6 position are potent protein synthesis inhibitors and active against multidrug-resistant respiratory pathogens. , 2001, Journal of medicinal chemistry.

[5]  K. Matsumoto,et al.  Synthesis and antibacterial activity of the tricyclic ketolides TE-802 and its analogs. , 2001, The Journal of antibiotics.

[6]  P. Rhomberg,et al.  Antimicrobial Resistance among Clinical Isolates ofStreptococcus pneumoniae in the United States during 1999–2000, Including a Comparison of Resistance Rates since 1994–1995 , 2001, Antimicrobial Agents and Chemotherapy.

[7]  R. Clark,et al.  Synthesis of 2-fluoro-6-O-propargyl-11,12-carbamate ketolides. A novel class of antibiotics. , 2000, Organic letters.

[8]  R. Clark,et al.  Synthesis and antibacterial activity of novel 6-O-substituted erythromycin A derivatives. , 2000, Bioorganic & Medicinal Chemistry Letters.

[9]  Zhenkun Ma and Peter A. Nemoto.  Discovery and Development of Ketolides as a New Generation of Macrolide Antimicrobial Agents , 2002 .