Principles: receptor theory in pharmacology.
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[1] D. Lewis,et al. The CB1 Cannabinoid Receptor Can Sequester G-Proteins, Making Them Unavailable to Couple to Other Receptors , 1999, The Journal of Neuroscience.
[2] K. Blumer,et al. Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors. , 1998, Molecular biology of the cell.
[3] Terry Kenakin,et al. A guide to drug discovery: Predicting therapeutic value in the lead optimization phase of drug discovery , 2003, Nature Reviews Drug Discovery.
[4] Terry Kenakin,et al. Efficacy at g-protein-coupled receptors , 2002, Nature Reviews Drug Discovery.
[5] H. Schild. Drug antagonism and pAx. , 1957, Pharmacological reviews.
[6] A. Trkola,et al. Co-receptors for HIV-1 entry. , 1997, Current opinion in immunology.
[7] R. Furchgott. The Classification of Adrenoceptors (Adrenergic Receptors). An Evaluation from the Standpoint of Receptor Theory , 1972 .
[8] R. Lefkowitz,et al. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. , 1980, The Journal of biological chemistry.
[9] A. J. Clark. The Rate of Action of Drugs on Cells , 1937 .
[10] T. Hall. The limitations of molecular pharmacology. , 1971, The Journal of clinical pharmacology and new drugs.
[11] J. Blanck,et al. Kinetics of Drug Action , 1977, Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology.
[12] S. Rees,et al. GPCR drug discovery through the exploitation of allosteric drug binding sites. , 2002, Receptors & channels.
[13] R. Lefkowitz,et al. Agonist-induced increase in apparent β-adrenergic receptor size , 1978 .
[14] C. Shayo,et al. Tiotidine, a histamine H2 receptor inverse agonist that binds with high affinity to an inactive G-protein-coupled form of the receptor. Experimental support for the cubic ternary complex model. , 2003, Molecular pharmacology.
[15] T. Kenakin. Efficacy as a vector: the relative prevalence and paucity of inverse agonism. , 2004, Molecular pharmacology.
[16] L. Bačáková,et al. Activation of muscarinic acetylcholine receptors via their allosteric binding sites. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[17] Terry Kenakin,et al. Drug efficacy at G protein-coupled receptors. , 2002, Annual review of pharmacology and toxicology.
[18] T. Gardella,et al. Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands. , 1999, Biochemistry.
[19] W. Paton,et al. A theory of drug action based on the rate of drug-receptor combination , 1961, Proceedings of the Royal Society of London. Series B. Biological Sciences.
[20] J. Schwartz,et al. Histamine H3‐receptor‐mediated [35S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors , 2002, British journal of pharmacology.
[21] T. Kenakin,et al. Inverse, protean, and ligand‐selective agonism: matters of receptor conformation , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[22] P. Morgan,et al. The Cubic Ternary Complex ReceptorOccupancy Model I. Model Description , 1996 .
[23] Ted L. Anderson,et al. On the Application of R -Curves and Maximum Load Toughness to Structures , 1988 .
[24] T. Costa,et al. Agonist Efficacy and Aliosteric Models of Receptor Action a , 1997, Annals of the New York Academy of Sciences.
[25] T. Schwartz,et al. High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist. , 2003, Molecular endocrinology.
[26] P. Leff. Inverse agonism: theory and practice. , 1995, TIPS - Trends in Pharmacological Sciences.
[27] J. Kukkonen,et al. Protean agonism at alpha2A-adrenoceptors. , 1998, Molecular pharmacology.
[28] Terry Kenakin,et al. Ligand-selective receptor conformations revisited: the promise and the problem. , 2003, Trends in pharmacological sciences.
[29] J. Black,et al. Operational models of pharmacological agonism , 1983, Proceedings of the Royal Society of London. Series B. Biological Sciences.
[30] G. Liljestrand,et al. Readings In Pharmacology , 1981 .
[31] Lakshmi A. Devi,et al. G-protein-coupled receptor heterodimerization modulates receptor function , 1999, Nature.
[32] P. Chidiac,et al. Agonist-induced modulation of inverse agonist efficacy at the beta 2-adrenergic receptor. , 1996, Molecular pharmacology.
[33] G. Pasternak,et al. 3H-naloxone benzoylhydrazone binding in MOR-1-transfected Chinese hamster ovary cells: evidence for G-protein-dependent antagonist binding. , 1998, The Journal of pharmacology and experimental therapeutics.
[34] R. Lefkowitz,et al. A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. , 1993, The Journal of biological chemistry.
[35] A Herz,et al. Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[36] Melanie G. Lee,et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor , 1998, Nature.
[37] A. Trautmann,et al. Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides , 1998, Current Biology.
[38] A Karlin,et al. On the application of "a plausible model" of allosteric proteins to the receptor for acetylcholine. , 1967, Journal of theoretical biology.
[39] S. A. Mathis,et al. Spontaneous Human B2 Bradykinin Receptor Activity Determines the Action of Partial Agonists as Agonists or Inverse Agonists , 1999, The Journal of Biological Chemistry.
[40] S. Nishikawa,et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 , 1996, Nature.
[41] W. Paton. On becoming and being a pharmacologist. , 1986, Annual review of pharmacology and toxicology.
[42] F. Ehlert,et al. Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. , 1988, Molecular pharmacology.
[43] R P STEPHENSON,et al. A MODIFICATION OF RECEPTOR THEORY , 1997, British journal of pharmacology and chemotherapy.
[44] Ariens Ej,et al. Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory. , 1954 .
[45] A. Scheer,et al. A Look at Receptor Efficacy. From the Signalling Network of the Cell to the Intramolecular Motion of the Receptor , 2000 .
[46] M. Maguire,et al. Relationship between the beta-adrenergic receptor and adenylate cyclase. , 1977, The Journal of biological chemistry.
[47] J. Changeux,et al. ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. , 1965, Journal of molecular biology.
[48] H. Rang,et al. The uptake of atropine and related drugs by intestinal smooth muscle of the guinea-pig in relation to acetylcholine receptors , 1965, Proceedings of the Royal Society of London. Series B. Biological Sciences.
[49] Christopher Haslett,et al. Bombesin and Substance P Analogues Differentially Regulate G-protein Coupling to the Bombesin Receptor , 2001, The Journal of Biological Chemistry.
[50] A. Maehle,et al. The emergence of the drug receptor theory , 2002, Nature Reviews Drug Discovery.
[51] B. Katz,et al. A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate , 1957, The Journal of physiology.
[52] Thron Cd. On the analysis of pharmacological experiments in terms of an allosteric receptor model. , 1973 .
[53] D. Mackay. A Critical Survey of Receptor Theories of Drug Action , 1977 .
[54] P. Casellas,et al. A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1 , 1997, The Journal of Biological Chemistry.
[55] Bernard,et al. Advances in Drug Research , 1964 .
[56] G. Uhl,et al. μ Opioid Receptor Phosphorylation, Desensitization, and Ligand Efficacy* , 1997, The Journal of Biological Chemistry.
[57] Bernard Katz,et al. Interaction at end-plate receptors between different choline derivatives , 1957, Proceedings of the Royal Society of London. Series B - Biological Sciences.