Proteomics: Guilt-by-association goes global

Clues to the function of a protein can be obtained by seeing whether it interacts with another protein of known function. This principle of guilt-by-association has now been applied to the entire protein complement of yeast.

[1]  B. Barrell,et al.  Life with 6000 Genes , 1996, Science.

[2]  A. Podtelejnikov,et al.  Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Perrot,et al.  Identification of proteins of the yeast protein map using genetically manipulated strains and peptide‐mass fingerprinting , 1996, Yeast.

[4]  P. Legrain,et al.  Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens , 1997, Nature Genetics.

[5]  J. Hoheisel Oligomer-chip technology , 1997 .

[6]  K. Brindle,et al.  Studies of metabolic control using NMR and molecular genetics , 1997, Journal of molecular recognition : JMR.

[7]  F Baganz,et al.  Systematic functional analysis of the yeast genome. , 1998, Trends in biotechnology.

[8]  S. Oliver,et al.  Metabolic control analysis as a tool in the elucidation of the function of novel genes , 1998 .

[9]  Andrew Hayes,et al.  Transcript analysis of 250 novel yeast genes from chromosome XIV , 1999, Yeast.

[10]  J D Beggs,et al.  Characterization of Sm‐like proteins in yeast and their association with U6 snRNA , 1999, The EMBO journal.

[11]  J. Yates,et al.  Direct analysis of protein complexes using mass spectrometry , 1999, Nature Biotechnology.

[12]  P. Thuriaux,et al.  A protein-protein interaction map of yeast RNA polymerase III. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[13]  H. Steen,et al.  Phenyl thiocarbamoyl and related derivatives of peptides: Edman chemistry in the gas phase , 1999 .

[14]  James R. Knight,et al.  A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae , 2000, Nature.