Genetics of lung-cancer susceptibility.

[1]  M H Skolnick,et al.  Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands. , 1994, Journal of the National Cancer Institute.

[2]  T. Tollefsbol,et al.  Strategies Targeting Telomerase Inhibition , 2009, Molecular biotechnology.

[3]  Ying Wang,et al.  A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. , 2009, American journal of human genetics.

[4]  A. Gazdar,et al.  Lung cancer in never smokers — a different disease , 2007, Nature Reviews Cancer.

[5]  M. Thun,et al.  Tobacco smoke and involuntary smoking. , 2004, IARC monographs on the evaluation of carcinogenic risks to humans.

[6]  H. Kantarjian,et al.  Genetic and Molecular Alterations , 2003 .

[7]  Paul Brennan,et al.  Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. , 2010, Journal of the National Cancer Institute.

[8]  R. Eeles,et al.  Li-Fraumeni and related syndromes: correlation between tumor type, family structure, and TP53 genotype. , 2003, Cancer research.

[9]  Zhongqiu Wang,et al.  CYP1A1 and GSTM1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis. , 2008, Lung cancer.

[10]  P. Vineis,et al.  Evidence of gene gene interactions in lung carcinogenesis in a large pooled analysis. , 2007, Carcinogenesis.

[11]  F. Bray,et al.  Lung cancer in Europe in 2000: epidemiology, prevention, and early detection. , 2003, The Lancet. Oncology.

[12]  D. Hunter,et al.  Textbook of cancer epidemiology , 2003 .

[13]  H. Wichmann,et al.  The cumulative risk of lung cancer among current, ex- and never-smokers in European men , 2004, British Journal of Cancer.

[14]  J. Ferlay,et al.  Cancer Incidence in Five Continents , 1970, Union Internationale Contre Le Cancer / International Union against Cancer.

[15]  K. Shianna,et al.  A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci , 2009, PLoS genetics.

[16]  W. Travis,et al.  United States lung carcinoma incidence trends: Declining for most histologic types among males, increasing among females , 1996, Cancer.

[17]  J. Yokota,et al.  Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. , 2009, Carcinogenesis.

[18]  Gayatry Mohapatra,et al.  Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR , 2005, Nature Genetics.

[19]  S. Chanock,et al.  Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. , 2009, Human molecular genetics.

[20]  K. Hemminki,et al.  Modification of cancer risks in offspring by sibling and parental cancers from 2,112,616 nuclear families , 2001, International journal of cancer.

[21]  H. Schuller Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? , 2009, Nature Reviews Cancer.

[22]  Wei Zheng,et al.  A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 , 2010, Nature Genetics.

[23]  Paolo Vineis,et al.  A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25 , 2008, Nature.

[24]  N. Tretyakova,et al.  Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers , 2002, Oncogene.

[25]  W. Ahrens,et al.  Multicenter case-control study of exposure to environmental tobacco smoke and lung cancer in Europe. , 1998, Journal of the National Cancer Institute.

[26]  Elisabeth Brambilla,et al.  Pathology and genetics of tumours of the lung , pleura, thymus and heart , 2004 .

[27]  F. Bray,et al.  Going up or coming down? The changing phases of the lung cancer epidemic from 1967 to 1999 in the 15 European Union countries. , 2004, European journal of cancer.

[28]  Daniel F. Gudbjartsson,et al.  A variant associated with nicotine dependence, lung cancer and peripheral arterial disease , 2008, Nature.

[29]  Paolo Vineis,et al.  Sequence variants at the TERT-CLPTM1L locus associate with many cancer types , 2009, Nature Genetics.

[30]  M. Spitz,et al.  Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. , 2009, Cancer research.

[31]  D. Gudbjartsson,et al.  Cancer as a Complex Phenotype: Pattern of Cancer Distribution within and beyond the Nuclear Family , 2004, PLoS medicine.

[32]  S. Grando,et al.  Cholinergic control of epidermal cohesion , 2006, Experimental dermatology.

[33]  P. Donnelly,et al.  Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip , 2009, PLoS genetics.

[34]  Issa J. Dahabreh,et al.  Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC , 2009, Nature Reviews Clinical Oncology.

[35]  Christopher I Amos,et al.  Common 5p15.33 and 6p21.33 variants influence lung cancer risk , 2008, Nature Genetics.

[36]  Zhifu Sun,et al.  Genetic variants and risk of lung cancer in never smokers: a genome-wide association study. , 2010, The Lancet. Oncology.

[37]  L. Le Marchand,et al.  Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. , 2002, Carcinogenesis.

[38]  A. Zlotta NAT2 Slow Acetylation, GSTM1 Null Genotype, and Risk of Bladder Cancer: Results from the Spanish Bladder Cancer Study and Meta-Analyses , 2006 .

[39]  Simon Heath,et al.  Lung cancer susceptibility locus at 5p15.33 , 2008, Nature Genetics.

[40]  J. Zahm,et al.  alpha3alpha5beta2-Nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells. , 2006, The American journal of pathology.

[41]  Nick Orr,et al.  Common genetic variation and human disease. , 2008, Advances in genetics.

[42]  Michael J Thun,et al.  Lung cancer death rates in lifelong nonsmokers. , 2006, Journal of the National Cancer Institute.

[43]  Luc Girard,et al.  Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. , 2007, Cancer research.

[44]  Kurt Straif,et al.  Carcinogenicity of household solid fuel combustion and of high-temperature frying. , 2006, The Lancet. Oncology.

[45]  G. Mills,et al.  Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1 , 2008, Nature Genetics.

[46]  P. Lansdorp Telomeres and disease , 2009, The EMBO journal.

[47]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[48]  Z. Herceg,et al.  Aberrant DNA methylation links cancer susceptibility locus 15q25.1 to apoptotic regulation and lung cancer. , 2010, Cancer research.

[49]  J. Lubiński,et al.  CHEK2 is a multiorgan cancer susceptibility gene. , 2004, American journal of human genetics.

[50]  D. Gudbjartsson,et al.  Familial risk of lung carcinoma in the Icelandic population. , 2004, JAMA.

[51]  L. Marchand,et al.  Erratum: Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk (Carcinogenesis (2002) vol. 23 (1343-1350)) , 2002 .

[52]  Richard Doll,et al.  Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies , 2000, BMJ : British Medical Journal.

[53]  J. Ferlay,et al.  Global Cancer Statistics, 2002 , 2005, CA: a cancer journal for clinicians.

[54]  Arnold Knijn,et al.  EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary. , 2009, European journal of cancer.

[55]  Y. Qiao,et al.  Estimation of cancer incidence and mortality attributable to smoking in China , 2010, Cancer Causes & Control.

[56]  L. Tanoue Serum B Vitamin Levels and Risk of Lung Cancer , 2012 .

[57]  H. Schuller,et al.  Nicotinic receptor‐associated modulation of stimulatory and inhibitory neurotransmitters in NNK‐induced adenocarcinoma of the lungs and pancreas , 2009, The Journal of pathology.

[58]  K. Hemminki Correspondence re: Risch, N.: Genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol. Biomark. Prev., 10: 733-741, 2001. , 2002, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[59]  F. Bray,et al.  International lung cancer trends by histologic type: Male:Female differences diminishing and adenocarcinoma rates rising , 2005, International journal of cancer.

[60]  N. Risch,et al.  The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. , 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[61]  C. Ortiz-de-Solórzano,et al.  Telomeres and telomerase in lung cancer. , 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[62]  A. Hansell,et al.  Genetic epidemiology and public health: hope, hype, and future prospects , 2005, The Lancet.

[63]  C. Mathers,et al.  Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 , 2010, International journal of cancer.

[64]  A. Jakubowska,et al.  Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers. , 2008, Carcinogenesis.

[65]  A. Okamoto,et al.  A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis. , 2001, Biochemical and biophysical research communications.

[66]  J. Varley,et al.  Relative frequency and morphology of cancers in carriers of germline TP53 mutations , 2001, Oncogene.

[67]  C. Begg,et al.  Computed Tomography Screening and Lung Cancer Outcomes , 2008 .

[68]  N. Grishin,et al.  Evolution of the regulators of G-protein signaling multigene family in mouse and human. , 2002, Genomics.

[69]  L. Kinlen Mortality from smoking in developed countries 1950-2000 , 1996, British Journal of Cancer.

[70]  Päivi Heikkilä,et al.  CHEK2 variant I157T may be associated with increased breast cancer risk , 2004, International journal of cancer.

[71]  J. Zahm,et al.  α3α5β2-Nicotinic Acetylcholine Receptor Contributes to the Wound Repair of the Respiratory Epithelium by Modulating Intracellular Calcium in Migrating Cells , 2006 .

[72]  Eduardo Lazcano-Ponce,et al.  Second Expert Report, Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective , 2009 .

[73]  Marshall W. Anderson,et al.  A major lung cancer susceptibility locus maps to chromosome 6q23-25. , 2004, American journal of human genetics.

[74]  R. Peto,et al.  Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study. , 2007, Human molecular genetics.

[75]  M. Garrett,et al.  CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin? , 2007, Nature Reviews Cancer.

[76]  P. Brennan,et al.  High cumulative risk of lung cancer death among smokers and nonsmokers in Central and Eastern Europe. , 2006, American journal of epidemiology.

[77]  Marshall W. Anderson,et al.  Fine Mapping of Chromosome 6q23-25 Region in Familial Lung Cancer Families Reveals RGS17 as a Likely Candidate Gene , 2009, Clinical Cancer Research.

[78]  G. Eklund,et al.  Analysis of hereditary component of cancer by use of a familial index by site , 2001, The Lancet.

[79]  E. Berg,et al.  World Health Organization Classification of Tumours , 2002 .

[80]  Erika Avila-Tang,et al.  Lung Cancer Occurrence in Never-Smokers: An Analysis of 13 Cohorts and 22 Cancer Registry Studies , 2008, PLoS medicine.

[81]  M. Olivier,et al.  Advances in Brief Lung Tumor KRAS and TP 53 Mutations in Nonsmokers Reflect Exposure to PAH-Rich Coal Combustion Emissions 1 , 2001 .

[82]  L. Ashworth,et al.  Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate. , 1998, Genomics.

[83]  E. Riboli,et al.  The second expert report, Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective , 2007 .

[84]  Wen Tan,et al.  Genetic variants on chromosome 15q25 associated with lung cancer risk in Chinese populations. , 2009, Cancer research.

[85]  David F Yankelevitz,et al.  CT screening for lung cancer: update 2007. , 2008, The oncologist.

[86]  K. Czene,et al.  Is Genetic Background Important in Lung Cancer Survival? , 2009, PloS one.

[87]  S. Heath,et al.  Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. , 2010, International journal of epidemiology.

[88]  K. Hemminki,et al.  Familial Lung Cancer and Aggregation of Smoking Habits: A Simulation of the Effect of Shared Environmental Factors on the Familial Risk of Cancer , 2005, Cancer Epidemiology Biomarkers & Prevention.

[89]  D. Christiani,et al.  EGFR-targeted therapies in lung cancer: predictors of response and toxicity. , 2009, Pharmacogenomics.