Post-transcriptional control of increased hepatic catalase gene expression in response to oxidative stress.

Catalase is an important member of the antioxidant network that protects the cell against reactive oxygen species (ROS). We studied catalase gene expression in the liver of rats exposed to oxidative stress induced by the ROS-generating drug nitrofurantoin (NF). Catalase enzymatic activity and content are enhanced by NF treatment. The corresponding increase in the steady state level of the messenger ribonucleic acid (mRNA) occurs without significant changes in transcription and seems therefore controlled post-transcriptionally. Indeed, RNA band-shift assays demonstrated a reduced binding of redox-sensitive cytoplasmic protein(s) to the 3' region of catalase mRNA in NF-treated rats, thus suggesting that the redox state of protein that binds to an antioxidant enzyme mRNA may play a role in the hepatic response to oxidative stress.

[1]  G. Cairo,et al.  Nitric-oxide-mediated activation of iron-regulatory protein controls hepatic iron metabolism during acute inflammation. , 1995, European journal of biochemistry.

[2]  L. Tacchini,et al.  Differential activation of heat-shock and oxidation-specific stress genes in chemically induced oxidative stress. , 1995, The Biochemical journal.

[3]  A. Girotti,et al.  Amplification and hyperexpression of the catalase gene in selenoperoxidase-deficient leukemia cells. , 1995, Archives of biochemistry and biophysics.

[4]  L. Clerch.  A 3′-Untranslated Region of Catalase Messenger-RNA Composed of a Stem-Loop and Dinucleotide Repeat Elements Binds a 69-kDa Redox-Sensitive Protein , 1995 .

[5]  A. Tomasi,et al.  Induction of Ferritin Synthesis by Oxidative Stress , 1995, The Journal of Biological Chemistry.

[6]  T. D. Schneider,et al.  Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection , 1994, Cell.

[7]  G. Maley,et al.  The effect of reducing reagents on binding of thymidylate synthase protein to thymidylate synthase messenger RNA. , 1994, The Journal of biological chemistry.

[8]  D. Reimer,et al.  Complete cDNA and 5' genomic sequences and multilevel regulation of the mouse catalase gene. , 1994, Genomics.

[9]  G. Cairo,et al.  Transferrin receptor gene expression during rat liver regeneration. Evidence for post-transcriptional regulation by iron regulatory factorB, a second iron-responsive element-binding protein. , 1994, The Journal of biological chemistry.

[10]  J. Eaton,et al.  Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[11]  L. Clerch,et al.  Rat lung contains a developmentally regulated manganese superoxide dismutase mRNA-binding protein. , 1993, The Journal of clinical investigation.

[12]  R. Tyrrell,et al.  Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. , 1993, The Journal of biological chemistry.

[13]  H. Sies.  Strategies of antioxidant defense , 1993 .

[14]  R. Mason,et al.  Free radicals in toxicology. , 1993, Toxicology and applied pharmacology.

[15]  R. Klausner,et al.  Regulating the fate of mRNA: The control of cellular iron metabolism , 1993, Cell.

[16]  Kenzo Sato,et al.  Negative regulation of catalase gene expression in hepatoma cells , 1992, Molecular and cellular biology.

[17]  G. Cairo,et al.  Regulation of transferrin, transferrin receptor, and ferritin genes in human duodenum. , 1992, Gastroenterology.

[18]  D. Massaro,et al.  Oxidation-reduction-sensitive binding of lung protein to rat catalase mRNA. , 1992, The Journal of biological chemistry.

[19]  B. Demple,et al.  Redox redux: The control of oxidative stress responses , 1991, Cell.

[20]  D. Massaro,et al.  Perinatal rat lung catalase gene expression: influence of corticosteroid and hyperoxia. , 1991, The American journal of physiology.

[21]  G. Storz,et al.  Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. , 1990, Science.

[22]  A. Richardson,et al.  Changes in the expression of superoxide dismutase and catalase as a function of age and dietary restriction. , 1989, Biochemical and biophysical research communications.

[23]  J. Doroshow,et al.  Resistance to hydrogen peroxide associated with altered catalase mRNA stability in MCF7 breast cancer cells. , 1989, Biochimica et biophysica acta.

[24]  J. Reddy,et al.  Comparison of constitutive and inducible levels of expression of peroxisomal beta-oxidation and catalase genes in liver and extrahepatic tissues of rat. , 1988, Cancer research.

[25]  R. Sutton,et al.  Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant. , 1987, The Journal of biological chemistry.

[26]  B. Halliwell,et al.  The measurement of free radical reactions in humans , 1987, FEBS letters.

[27]  S. Shibahara,et al.  Cloning and expression of cDNA for rat heme oxygenase. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Parshad,et al.  Influence of added catalase on chromosome stability and neoplastic transformation of mouse cells in culture. , 1985, British Journal of Cancer.

[29]  O. Uhlenbeck,et al.  Nucleoside and nucleotide inactivation of R17 coat protein: evidence for a transient covalent RNA-protein bond. , 1985, Biochemistry.

[30]  O. Griffith,et al.  Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. , 1980, Analytical biochemistry.

[31]  I. Fridovich,et al.  Antioxidant defenses in the lung. , 1986, Annual review of physiology.

[32]  M. Hijikata,et al.  Complete nucleotide sequence of cDNA and deduced amino acid sequence of rat liver catalase. , 1986, Proceedings of the National Academy of Sciences of the United States of America.