Advanced Nanomaterials in the Clinical Scenario: Virtues and Consequences

Nanotechnology is the recently developed scientific discipline that copes with the application of nanoscience with the engineering of functional systems at the molecular extent. In the past era, the nanomaterials, “the basic units of nanotechnology,” were considered as the passive nanoscale particle structures or materials designed to perform only one task. Currently, nanotechnology is considered a broad and interdisciplinary area of advanced scientific research, which has a high impact on different fields of science, including biomedical research. Throughout the years of research, these nanomaterials are transformed into advanced nanomaterials or multifunctional nanoparticles (in medicine) which have different properties enabling those as multitasking nanoscale materials. For example, in the current scenario, the technologies developed for advanced nanomaterials are considered to have the potential for transfiguring how biomaterials are synthesized, functionalized, and utilized in different biomedical and medical applications such as actuators, drug delivery biomaterials, and biosensors. Even though these advanced nanomaterials are already having a significant commercial impact in the biomedical field, which is increasing day by day, it has its pros and cons, taking into account different issues or ideas which are discussed in this chapter in detail.

[1]  Salomeh Jelveh,et al.  Gold Nanoparticles as Radiation Sensitizers in Cancer Therapy , 2010, Radiation research.

[2]  Dik van de Meent,et al.  Considerations on the EU definition of a nanomaterial: science to support policy making. , 2013, Regulatory toxicology and pharmacology : RTP.

[3]  Michihiro Nakamura,et al.  Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles , 2007, International journal of cancer.

[4]  Kevin Robbie,et al.  Nanomaterials and nanoparticles: Sources and toxicity , 2007, Biointerphases.

[5]  Carla Renata Arciola,et al.  A review of the biomaterials technologies for infection-resistant surfaces. , 2013, Biomaterials.

[6]  Paresh Chandra Ray,et al.  Toxicity and Environmental Risks of Nanomaterials: Challenges and Future Needs , 2009, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

[7]  Z. Kuncic,et al.  Nanoparticle radio-enhancement: principles, progress and application to cancer treatment , 2018, Physics in medicine and biology.

[8]  Xiaogang Peng,et al.  Experimental Determination of the Extinction Coefficient of CdTe, CdSe, and CdS Nanocrystals , 2003 .

[9]  R. Baskar,et al.  Cancer and Radiation Therapy: Current Advances and Future Directions , 2012, International journal of medical sciences.

[10]  B. Wang,et al.  Physicochemical Origin for Free Radical Generation of Iron Oxide Nanoparticles in Biomicroenvironment: Catalytic Activities Mediated by Surface Chemical States , 2013 .

[11]  Meysam Rahmat,et al.  Carbon nanotube–polymer interactions in nanocomposites: A review , 2011 .

[12]  M. Kamal,et al.  Nanotechnology-based approaches in anticancer research , 2012, International journal of nanomedicine.

[13]  Freitas Robert A.Jr CURRENT STATUS OF NANOMEDICINE AND MEDICAL NANOROBOTICS , 2005 .

[14]  Xiaowei Kong,et al.  Application of nanodiagnostics in point-of-care tests for infectious diseases , 2017, International journal of nanomedicine.

[15]  Yoseph Bar-Cohen,et al.  Biomimetics : Biologically Inspired Technologies , 2011 .

[16]  Robert Langer,et al.  A BioMEMS review: MEMS technology for physiologically integrated devices , 2004, Proceedings of the IEEE.

[17]  Martin Steinhart,et al.  Nanotubes by template wetting: a modular assembly system. , 2004, Angewandte Chemie.

[18]  Yiyong Mai,et al.  Self-assembly of block copolymers. , 2012, Chemical Society reviews.

[19]  V. Muzykantov,et al.  Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities , 2012, Science.

[20]  Amanda S. Barnard,et al.  Visualization of Hybridization in Nanocarbon Systems , 2005 .

[21]  N. Kotov,et al.  Zinc oxide nanoparticle suspensions and layer-by-layer coatings inhibit staphylococcal growth. , 2016, Nanomedicine : nanotechnology, biology, and medicine.

[22]  M. Kotaki,et al.  A review on polymer nanofibers by electrospinning and their applications in nanocomposites , 2003 .

[23]  B. Bhushan Springer Handbook of Nanotechnology , 2017 .

[24]  N. Vrana,et al.  Use of Nanoparticles in Tissue Engineering and Regenerative Medicine , 2019, Front. Bioeng. Biotechnol..

[25]  T. Lim,et al.  An Introduction to Electrospinning and Nanofibers , 2005 .

[26]  A Curtis,et al.  Nantotechniques and approaches in biotechnology. , 2001, Trends in biotechnology.

[27]  Shawn M. Douglas,et al.  Self-assembly of DNA into nanoscale three-dimensional shapes , 2009, Nature.

[28]  Fang Liu,et al.  Conjugation of Functionalized SPIONs with Transferrin for Targeting and Imaging Brain Glial Tumors in Rat Model , 2012, PloS one.

[29]  Zahi A Fayad,et al.  Nanotechnology in Medical Imaging: Probe Design and Applications , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[30]  P. Rothemund Folding DNA to create nanoscale shapes and patterns , 2006, Nature.

[31]  S. Hehlgans,et al.  The role of recent nanotechnology in enhancing the efficacy of radiation therapy. , 2015, Biochimica et biophysica acta.

[32]  Amanda S. Barnard,et al.  Size, Shape, Stability, and Color of Plasmonic Silver Nanoparticles , 2014 .

[33]  Alexander Tropsha,et al.  Chemical basis of interactions between engineered nanoparticles and biological systems. , 2014, Chemical reviews.

[34]  C. Buzea,et al.  Nanomaterials and their Classification , 2017 .

[35]  Yelena Katsenovich,et al.  Nanomedicine: magnetic nanoparticles and their biomedical applications. , 2010, Current medicinal chemistry.

[36]  Ssang-Goo Cho,et al.  The potential of nanoparticles in stem cell differentiation and further therapeutic applications , 2016, Biotechnology journal.

[37]  Katsuhiko Ariga,et al.  Nanoarchitectonics for Dynamic Functional Materials from Atomic‐/Molecular‐Level Manipulation to Macroscopic Action , 2016, Advanced materials.

[38]  K. Alharbi,et al.  Role and implications of nanodiagnostics in the changing trends of clinical diagnosis. , 2014, Saudi journal of biological sciences.

[39]  Loet Leydesdorff,et al.  Nanotechnology as a field of science: Its delineation in terms of journals and patents , 2007, Scientometrics.

[40]  Parth Malik,et al.  Nanobiosensors: Concepts and Variations , 2013 .

[41]  R. Joseph,et al.  Nanotechnology-A New Prospective in Organic Coating - Review , 2011 .

[42]  Harald F Krug,et al.  Nanosafety research--are we on the right track? , 2014, Angewandte Chemie.

[43]  V. Adam,et al.  Magnetic nanoparticles and targeted drug delivering. , 2010, Pharmacological research.

[44]  M. Saifi,et al.  Nanotoxicology: Toxicity and Risk Assessment of Nanomaterials , 2018 .

[45]  P. Dobson,et al.  Nanoparticle augmented radiation treatment decreases cancer cell proliferation. , 2012, Nanomedicine : nanotechnology, biology, and medicine.

[46]  Julie W. Fitzpatrick,et al.  Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy , 2005, Particle and Fibre Toxicology.

[47]  Joginder Singh,et al.  Biological Biosensors for Monitoring and Diagnosis , 2020, Microbial Biotechnology: Basic Research and Applications.

[48]  T. Xia,et al.  Toxic Potential of Materials at the Nanolevel , 2006, Science.

[49]  Chao Wu,et al.  Enhanced supercapacitive performance of delaminated two-dimensional titanium carbide/carbon nanotube composites in alkaline electrolyte , 2015 .

[50]  R. Guleria,et al.  Biomarkers in cancer screening, research and detection: present and future: a review , 2006, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

[51]  Pedro Viana Baptista Nanodiagnostics: leaving the research lab to enter the clinics? , 2014, Diagnosis.

[52]  D. Warheit,et al.  Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks. , 2008, Pharmacology & therapeutics.

[53]  S. Bhattarai,et al.  Gold nanotriangles: scale up and X-ray radiosensitization effects in mice. , 2017, Nanoscale.

[54]  N. Gu,et al.  Shape-Dependent Radiosensitization Effect of Gold Nanostructures in Cancer Radiotherapy: Comparison of Gold Nanoparticles, Nanospikes, and Nanorods. , 2017, ACS applied materials & interfaces.

[55]  J. Kjems,et al.  Self-assembly of a nanoscale DNA box with a controllable lid , 2009, Nature.

[56]  Ick Chan Kwon,et al.  Multifunctional nanoparticles for multimodal imaging and theragnosis. , 2012, Chemical Society reviews.

[57]  Z. Fan,et al.  Zinc oxide nanostructures: synthesis and properties. , 2005, Journal of nanoscience and nanotechnology.

[58]  Ying Wang,et al.  Analogic China map constructed by DNA , 2006 .

[59]  R D Tyagi,et al.  Engineered nanoparticles in wastewater and wastewater sludge--evidence and impacts. , 2010, Waste management.

[60]  Krasimir Vasilev,et al.  Antibacterial surfaces for biomedical devices , 2009, Expert review of medical devices.

[61]  Sacha Loeve Design and Aesthetics in Nanotechnology , 2018 .

[62]  Warren C W Chan,et al.  Nanoparticle-mediated cellular response is size-dependent. , 2008, Nature nanotechnology.

[63]  Weihong Tan,et al.  Nanotechnology in therapeutics : a focus on nanoparticles as a drug delivery system Review , 2008 .

[64]  H. Olmez,et al.  Surface modifications for antimicrobial effects in the healthcare setting: a critical overview. , 2018, The Journal of hospital infection.

[65]  F. Mussano,et al.  Surface Treatments and Functional Coatings for Biocompatibility Improvement and Bacterial Adhesion Reduction in Dental Implantology , 2016 .

[66]  T. Webster,et al.  Nanotechnology and nanomaterials: Promises for improved tissue regeneration , 2009 .

[67]  Shawn M. Douglas,et al.  Folding DNA into Twisted and Curved Nanoscale Shapes , 2009, Science.

[68]  S. Turner,et al.  Recent advances in alternating copolymers: The synthesis, modification, and applications of precision polymers , 2017 .

[69]  M. Terrones,et al.  Pure and doped boron nitride nanotubes , 2007 .

[70]  Morteza Mahmoudi,et al.  Toxicity evaluations of superparamagnetic iron oxide nanoparticles: cell "vision" versus physicochemical properties of nanoparticles. , 2011, ACS nano.

[71]  Lei Wen,et al.  Carbon Nanotubes and Graphene for Flexible Electrochemical Energy Storage: from Materials to Devices , 2016, Advanced materials.

[72]  Yoseph Bar-Cohen Biologically inspired technologies using artificial muscles , 2005, SPIE MOEMS-MEMS.

[73]  A. Georgakilas,et al.  Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles , 2017, Cancers.

[74]  A. Rai,et al.  A smartphone dongle for diagnosis of infectious diseases at the point of care , 2015, Science Translational Medicine.

[75]  A. S. Moses,et al.  Imaging and drug delivery using theranostic nanoparticles. , 2010, Advanced drug delivery reviews.

[76]  M. Mortimer,et al.  Ecotoxicity of nanoparticles of CuO and ZnO in natural water. , 2010, Environmental pollution.

[77]  Hao Yan,et al.  DNA Gridiron Nanostructures Based on Four-Arm Junctions , 2013, Science.

[78]  A. Cuschieri,et al.  The cytotoxicity of polycationic iron oxide nanoparticles: Common endpoint assays and alternative approaches for improved understanding of cellular response mechanism , 2012, Journal of Nanobiotechnology.

[79]  Shoogo Ueno,et al.  Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[80]  Arben Merkoçi,et al.  Nanobiosensors in diagnostics , 2016, Nanobiomedicine.

[81]  Ali Majdi,et al.  Nanotoxicology and nanoparticle safety in biomedical designs , 2011, International journal of nanomedicine.

[82]  Sanghamitra Chatterjee,et al.  Nanomaterials based electrochemical sensors for biomedical applications. , 2013, Chemical Society reviews.

[83]  Efstathios Karathanasis,et al.  Shaping cancer nanomedicine: the effect of particle shape on the in vivo journey of nanoparticles. , 2014, Nanomedicine.

[84]  G. Sheline Radiation therapy of brain tumors , 1977, Cancer.

[85]  Yan Deng,et al.  Aptamer selection and applications for breast cancer diagnostics and therapy , 2017, Journal of Nanobiotechnology.

[86]  Hao Yan,et al.  DNA Origami with Complex Curvatures in Three-Dimensional Space , 2011, Science.

[87]  Chad A. Mirkin,et al.  Drivers of biodiagnostic development , 2009, Nature.

[88]  Patrick Couvreur,et al.  Fe3O4/chitosan nanocomposite for magnetic drug targeting to cancer , 2012 .

[89]  P. Fu,et al.  Phototoxicity of zinc oxide nanoparticles in HaCaT keratinocytes-generation of oxidative DNA damage during UVA and visible light irradiation. , 2013, Journal of nanoscience and nanotechnology.

[90]  Hong Yang,et al.  Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles. , 2012, ACS nano.

[91]  M Cloutier,et al.  Antibacterial Coatings: Challenges, Perspectives, and Opportunities. , 2015, Trends in biotechnology.

[92]  S. Santra,et al.  Nanobioimaging and sensing of infectious diseases☆ , 2009, Advanced Drug Delivery Reviews.

[93]  A. Miller,et al.  Reporting results of cancer treatment , 1981, Cancer.

[94]  Syed Abeer,et al.  Future Medicine: Nanomedicine , 2012 .

[95]  Vojtech Adam,et al.  Quantum Dots — Characterization, Preparation and Usage in Biological Systems , 2009, International journal of molecular sciences.

[96]  O. Tillement,et al.  Radiation dose enhancement of gadolinium-based AGuIX nanoparticles on HeLa cells. , 2014, Nanomedicine : nanotechnology, biology, and medicine.

[97]  Dana Petersen,et al.  Current and future applications of nanotechnology in plastic and reconstructive surgery , 2014 .

[98]  S. Bakand,et al.  In vitro cytotoxicity assessment of selected nanoparticles using human skin fibroblasts , 2008 .

[99]  Jana Drbohlavová,et al.  Modern Micro and Nanoparticle-Based Imaging Techniques , 2012, Sensors.

[100]  G. Oberdörster,et al.  Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology , 2010, Journal of internal medicine.