The Diversity of Chemoprotective Glucosinolates in Moringaceae (Moringa spp.)

[1]  Garima,et al.  Wild and domesticated Moringa oleifera differ in taste, glucosinolate composition, and antioxidant potential, but not myrosinase activity or protein content , 2018, Scientific Reports.

[2]  H. Chiba,et al.  Comparison of chemical structures and cytoprotection abilities between direct and indirect antioxidants , 2017 .

[3]  S. Friend,et al.  Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes , 2017, Science Translational Medicine.

[4]  N. Mutters,et al.  Natural isothiocyanates express antimicrobial activity against developing and mature biofilms of Pseudomonas aeruginosa. , 2017, Fitoterapia.

[5]  J. Fahey Moringa oleifera: A review of the medicinal potential , 2017 .

[6]  T. Kensler,et al.  KEAP1 and done? Targeting the NRF2 pathway with sulforaphane , 2017, Trends in food science & technology.

[7]  A. Herman-Antosiewicz,et al.  Isothiocyanates as effective agents against enterohemorrhagic Escherichia coli: insight to the mode of action , 2016, Scientific Reports.

[8]  S. Wehage,et al.  Sulforaphane Bioavailability from Glucoraphanin-Rich Broccoli: Control by Active Endogenous Myrosinase , 2015, PloS one.

[9]  I. Raskin,et al.  Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice. , 2015, Molecular nutrition & food research.

[10]  E. Mazzon,et al.  Administration of 4-(α-L-Rhamnosyloxy)-benzyl Isothiocyanate Delays Disease Phenotype in SOD1G93A Rats: A Transgenic Model of Amyotrophic Lateral Sclerosis , 2015, BioMed research international.

[11]  Mark G. M. Aarts,et al.  Isolation and identification of 4-α-rhamnosyloxy benzyl glucosinolate in Noccaea caerulescens showing intraspecific variation. , 2015, Phytochemistry.

[12]  N. Morin,et al.  Flora of North America North of Mexico , 2015 .

[13]  J. Fahey,et al.  Purification of active myrosinase from plants by aqueous two-phase counter-current chromatography. , 2015, Phytochemical analysis : PCA.

[14]  A. Zimmerman,et al.  Sulforaphane treatment of autism spectrum disorder (ASD) , 2014, Proceedings of the National Academy of Sciences.

[15]  M. Maldini,et al.  'Moringa oleifera: study of phenolics and glucosinolates by mass spectrometry'. , 2014, Journal of mass spectrometry : JMS.

[16]  I. Raskin,et al.  Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. , 2014, Phytochemistry.

[17]  A. Muñoz,et al.  Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China , 2014, Cancer Prevention Research.

[18]  E. Mazzon,et al.  Antiinflammatory activity of glucomoringin isothiocyanate in a mouse model of experimental autoimmune encephalomyelitis. , 2014, Fitoterapia.

[19]  J. Groopman,et al.  Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. , 2014, Toxicological sciences : an official journal of the Society of Toxicology.

[20]  D. Angelino,et al.  Glucosinolate hydrolysis and bioavailability of resulting isothiocyanates: Focus on glucoraphanin , 2014 .

[21]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[22]  Zhaoping Li,et al.  Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. , 2014, Food & function.

[23]  E. Mazzon,et al.  Antibacterial Activity of Glucomoringin Bioactivated with Myrosinase against Two Important Pathogens Affecting the Health of Long-Term Patients in Hospitals , 2013, Molecules.

[24]  J. Fahey,et al.  Urease from Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates. , 2013, Biochemical and biophysical research communications.

[25]  T. Kensler,et al.  Health span extension through green chemoprevention. , 2013, The virtual mentor : VM.

[26]  A. Dinkova-Kostova,et al.  Glucosinolates and isothiocyanates in health and disease. , 2012, Trends in molecular medicine.

[27]  C. Olsen,et al.  Glucosinolate structures in evolution. , 2012, Phytochemistry.

[28]  T. Kensler,et al.  Notes from the Field: “Green” Chemoprevention as Frugal Medicine , 2012, Cancer Prevention Research.

[29]  Mark E. Olson,et al.  Moringa oleifera: Un árbol multiusos para las zonas tropicales secas , 2011 .

[30]  J. Pezzuto,et al.  Inhibition of Lipopolysaccharide-Induced Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Expression by 4-[(2′-O-acetyl-α-L-Rhamnosyloxy)Benzyl]Isothiocyanate from Moringa oleifera , 2011, Nutrition and cancer.

[31]  A. Muñoz,et al.  Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China , 2011, Cancer Prevention Research.

[32]  J. Fahey,et al.  Development of tissue culture methods for the rescue and propagation of endangered Moringa Spp. germplasm , 2004, Economic Botany.

[33]  F. Crea,et al.  Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana , 2010 .

[34]  J. Pezzuto,et al.  Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. , 2010, Bioorganic & medicinal chemistry.

[35]  Jan Meulenbeld The Trees Called Sigru (Moringa sp.), along with a study of the drugs used in errhines , 2009 .

[36]  J. Fahey,et al.  Cultivar Effect on Moringa oleifera Glucosinolate Content and Taste: A Pilot Study , 2009, Ecology of food and nutrition.

[37]  I. Hyodo,et al.  Dietary Sulforaphane-Rich Broccoli Sprouts Reduce Colonization and Attenuate Gastritis in Helicobacter pylori–Infected Mice and Humans , 2009, Cancer Prevention Research.

[38]  A. Dinkova-Kostova,et al.  Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles , 2008, Proceedings of the National Academy of Sciences.

[39]  Paul Talalay,et al.  Direct and indirect antioxidant properties of inducers of cytoprotective proteins. , 2008, Molecular nutrition & food research.

[40]  A. Nel,et al.  Importance of oxidative stress in the pathogenesis and treatment of asthma , 2008, Current opinion in allergy and clinical immunology.

[41]  J. Fahey,et al.  Improved hydrophilic interaction chromatography method for the identification and quantification of glucosinolates. , 2007, Journal of chromatography. A.

[42]  A. Dinkova-Kostova,et al.  Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants. , 2007, Medicinal chemistry (Shariqah (United Arab Emirates)).

[43]  Barbara Ann Halkier,et al.  Biology and biochemistry of glucosinolates. , 2006, Annual review of plant biology.

[44]  J. Fahey,et al.  Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori. , 2005, Planta medica.

[45]  J. Fahey,et al.  Glucoraphanin level in broccoli seed is largely determined by genotype , 2005 .

[46]  J. Fahey,et al.  Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Part 1. , 2005 .

[47]  P. Talalay,et al.  Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[48]  J. Fahey,et al.  Genetic and environmental effects on glucosinolate content and chemoprotective potency of broccoli , 2004 .

[49]  A. Dinkova-Kostova,et al.  The "Prochaska" microtiter plate bioassay for inducers of NQO1. , 2004, Methods in enzymology.

[50]  M. Kwak,et al.  Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. , 2003, Biochemical and biophysical research communications.

[51]  J. Fahey,et al.  Separation and purification of glucosinolates from crude plant homogenates by high-speed counter-current chromatography. , 2003, Journal of chromatography. A.

[52]  P. Kroon,et al.  Profiling glucosinolates and phenolics in vegetative and reproductive tissues of the multi-purpose trees Moringa oleifera L. (horseradish tree) and Moringa stenopetala L. , 2003, Journal of agricultural and food chemistry.

[53]  P. Taylor,et al.  Developmental changes of sinigrin and glucoraphanin in three Brassica species (Brassica nigra, Brassica juncea and Brassica oleracea var. italica) , 2002 .

[54]  B. Tomkins,et al.  The effect of post-harvest and packaging treatments on glucoraphanin concentration in broccoli (Brassica oleracea var. italica). , 2002, Journal of agricultural and food chemistry.

[55]  J. Fahey,et al.  Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea Var. italica) sprouts and their effect on the induction of mammalian phase 2 enzymes. , 2002, Journal of agricultural and food chemistry.

[56]  T. Kensler,et al.  Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[57]  M. Olson Intergeneric Relationships within the Caricaceae‐Moringaceae Clade (Brassicales) and Potential Morphological Synapomorphies of the Clade and Its Families , 2002, INTERNATIONAL JOURNAL PLANT SCIENCES.

[58]  A. Dinkova-Kostova,et al.  Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: The indirect antioxidant effects of sulforaphane , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[59]  J. Fahey,et al.  Phytochemicals from cruciferous plants protect against cancer by modulating carcinogen metabolism. , 2001, The Journal of nutrition.

[60]  J. Fahey,et al.  Analysis of glucosinolates from broccoli and other cruciferous vegetables by hydrophilic interaction liquid chromatography. , 2001, Journal of chromatography. A.

[61]  J. Fahey,et al.  The chemical diversity and distribution of glucosinolates and isothiocyanates among plants. , 2001, Phytochemistry.

[62]  J. Fahey,et al.  Capacity of Broccoli to Induce a Mammalian Chemoprotective Enzyme Varies among Inbred Lines , 2000 .

[63]  Y. Zhang,et al.  Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. , 2000, Carcinogenesis.

[64]  C. Baird,et al.  The pilot study. , 2000, Orthopedic nursing.

[65]  J. Fahey,et al.  Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes. , 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[66]  J. Fahey,et al.  An unusual case of 'uncompetitive activation' by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings. , 1999, The Biochemical journal.

[67]  M. Hendrickx,et al.  Kinetic study of the irreversible thermal and pressure inactivation of myrosinase from broccoli (Brassica oleracea L. Cv. italica). , 1999, Journal of agricultural and food chemistry.

[68]  J. Fahey,et al.  Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[69]  T. Kensler Chemoprevention by inducers of carcinogen detoxication enzymes. , 1997, Environmental health perspectives.

[70]  G. Stoner,et al.  Isothiocyanates and plant polyphenols as inhibitors of lung and esophageal cancer. , 1997, Cancer letters.

[71]  M. Morra,et al.  Control of soil-borne plant pests using glucosinolate-containing plants , 1997 .

[72]  R. Heaney,et al.  Glucosinolates in crop plants , 1997 .

[73]  M. Palada Moringa (Moringa oleifera Lam.): A Versatile Tree Crop with Horticultural Potential in the Subtropical United States , 1996 .

[74]  J. Fahey,et al.  Cancer chemoprotective effects of cruciferous vegetables , 1996 .

[75]  J. Fahey,et al.  Comprehensive chromatographic and spectroscopic methods for the separation and identification of intact glucosinolates. , 1996, Analytical biochemistry.

[76]  S. Hecht Chemoprevention by isothiocyanates , 1995, Journal of cellular biochemistry. Supplement.

[77]  T. Kensler,et al.  Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[78]  K. Gardens,et al.  Flora of Somalia , 1993 .

[79]  A. Santamaria,et al.  Rapid detection of inducers of enzymes that protect against carcinogens. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[80]  C. Cho,et al.  A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[81]  M. Chase,et al.  Silica gel: An ideal material for field preservation of leaf samples for DNA studies , 1991 .

[82]  G. B. Rose,et al.  Glucosinolate composition of seeds from 297 species of wild plants , 1991 .

[83]  U. Eilert,et al.  Elicitor-Induced Accumulation of Acridone Alkaloid Epoxides in Ruta graveolens Suspension Cultures. , 1984, Planta medica.

[84]  O. Olsen,et al.  Isolation of glucosinolates and the identification of o-(α-l-rhamnopyranosyloxy)benzylglucosinolate from Reseda odorata , 1979 .

[85]  B. El-menshawi,et al.  Isothiocyanates in myrosinase-treated seed extracts of Moringa peregrina , 1979 .

[86]  A. Kjær,et al.  Glucosinolates in Tersonia brevipes (Gyrostemonaceae) , 1979 .

[87]  K. Dornberger,et al.  [Investigations of the isothiocyanates erysolin and sulforaphan of Cardaria draba L]. , 1975, Die Pharmazie.

[88]  H. Sørensen o-(α-L-Rhamnopyranosyloxy)benzylamine and o-hydroxybenzylamine in Reseda odorata. , 1970 .

[89]  T. Hata,et al.  Studies on the Myrosinase in Mustard Seed , 1968 .

[90]  P. Kristian,et al.  Antifungal activity of isothiocyanates and related compounds. I. Naturally occurring isothiocyanates and their analogues. , 1967, Applied microbiology.

[91]  P. Kristian,et al.  Antifungal Activity of Isothiocyanates and Related Compounds , 1967 .

[92]  B. Badgett PART ONE: THE MUSTARD OIL GLUCOSIDE FROM MORINGA OLEIFERA, SEED. PART TWO: ASCORBIC ACID ANALOGUES WITH DEOXY SIDE CHAINS , 1964 .