Structural Elucidation of Post-Translational Modifications in Monoclonal Antibodies
暂无分享,去创建一个
John E. Schiel | Darryl Davis | Wenzhou Li | Wenzhou Li | Trina Formolo | Darryl L Davis | S. Benchaar | James L. Kerwin | Andrew Mahan | Sabrina A. Benchaar | J. Kerwin | Trina Formolo | Andrew D. Mahan
[1] Richard D. Smith,et al. Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes. , 2008, Journal of proteome research.
[2] R Shapiro,et al. Sites of nonenzymatic glycosylation of human hemoglobin A. , 1980, The Journal of biological chemistry.
[3] W. Lehmann,et al. Analysis of isoaspartate in peptides by electrospray tandem mass spectrometry , 2000, Protein science : a publication of the Protein Society.
[4] Alavattam Sreedhara,et al. Role of surface exposed tryptophan as substrate generators for the antibody catalyzed water oxidation pathway. , 2013, Molecular pharmaceutics.
[5] André M Deelder,et al. IgG glycosylation analysis , 2009, Proteomics.
[6] W. Fridman,et al. FcγR: The key to optimize therapeutic antibodies? , 2007 .
[7] Jing Li,et al. Research and development of next generation of antibody-based therapeutics , 2010, Acta Pharmacologica Sinica.
[8] Jason C Rouse,et al. Unit mass baseline resolution for an intact 148 kDa therapeutic monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry. , 2011, Analytical chemistry.
[9] Bruce A Kerwin,et al. Characterization of site-specific glycation during process development of a human therapeutic monoclonal antibody. , 2011, Journal of pharmaceutical sciences.
[10] R. Keck. The use of t-butyl hydroperoxide as a probe for methionine oxidation in proteins. , 1996, Analytical biochemistry.
[11] Catherine D. Kim,et al. Determination of the origin of the N‐terminal pyro‐glutamate variation in monoclonal antibodies using model peptides , 2007, Biotechnology and bioengineering.
[12] N. Lundell,et al. Sample preparation for peptide mapping--A pharmaceutical quality-control perspective. , 1999, Analytical biochemistry.
[13] M. Davies,et al. Evidence for the formation of adducts and S-(carboxymethyl)cysteine on reaction of alpha-dicarbonyl compounds with thiol groups on amino acids, peptides, and proteins. , 2005, Chemical research in toxicology.
[14] M. Roberts,et al. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in clinical chemistry. , 2003, Clinica chimica acta; international journal of clinical chemistry.
[15] Ronald T Borchardt,et al. Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization. , 2006, Journal of pharmaceutical sciences.
[16] Characterization of the Isomerization Products of Aspartate Residues at Two Different Sites in a Monoclonal Antibody , 2011, Pharmaceutical Research.
[17] Hyung-Ryong Kim,et al. An Involvement of Oxidative Stress in Endoplasmic Reticulum Stress and Its Associated Diseases , 2012, International journal of molecular sciences.
[18] R. Ionescu,et al. Fragmentation of monoclonal antibodies , 2011, mAbs.
[19] Jean-Luc Teillaud,et al. Impact of Glycosylation on Effector Functions of Therapeutic IgG † , 2010, Pharmaceuticals.
[20] Alain Balland,et al. Characterization of nonenzymatic glycation on a monoclonal antibody. , 2007, Analytical chemistry.
[21] Jolon M. Dyer,et al. Profiling of residue-level photo-oxidative damage in peptides , 2010, Amino Acids.
[22] Jennifer Liu,et al. Determination of tryptophan oxidation of monoclonal antibody by reversed phase high performance liquid chromatography. , 2007, Journal of chromatography. A.
[23] Yaning Wang,et al. Accurate determination of succinimide degradation products using high fidelity trypsin digestion peptide map analysis. , 2011, Analytical chemistry.
[24] Yiming Li,et al. Characterization of the degradation products of a color-changed monoclonal antibody: tryptophan-derived chromophores. , 2014, Analytical chemistry.
[25] J L Cleland,et al. Antioxidants for prevention of methionine oxidation in recombinant monoclonal antibody HER2. , 1997, Journal of pharmaceutical sciences.
[26] A. Alexander,et al. Monitoring of IgG antibody thermal stability by micellar electrokinetic capillary chromatography and matrix-assisted laser desorption/ionization mass spectrometry. , 1995, Analytical chemistry.
[27] George C Tseng,et al. Statistical analysis of electron transfer dissociation pairwise fragmentation patterns. , 2011, Analytical chemistry.
[28] S. Clarke,et al. Effect of adjacent histidine and cysteine residues on the spontaneous degradation of asparaginyl- and aspartyl-containing peptides. , 2009, International journal of peptide and protein research.
[29] Hongcheng Liu,et al. Characterization of the stability of a fully human monoclonal IgG after prolonged incubation at elevated temperature. , 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[30] S. Moore,et al. The sequence of amino acid residues in bovine pancreatic ribonuclease: revisions and confirmations. , 1963, The Journal of biological chemistry.
[31] M. Matsumura,et al. Isomerization of a single aspartyl residue of anti-epidermal growth factor receptor immunoglobulin gamma2 antibody highlights the role avidity plays in antibody activity. , 2008, Biochemistry.
[32] E. Stadtman,et al. Fenton chemistry. Amino acid oxidation. , 1991, The Journal of biological chemistry.
[33] A. Agulnik,et al. The HLA-A*0201-restricted H-Y antigen contains a posttranslationally modified cysteine that significantly affects T cell recognition. , 1997, Immunity.
[34] W. Stites,et al. Comparing the effect on protein stability of methionine oxidation versus mutagenesis: steps toward engineering oxidative resistance in proteins. , 2001, Protein engineering.
[35] K. Ohtsubo,et al. Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins. , 2009, Carbohydrate research.
[36] M. Davies,et al. The oxidative environment and protein damage. , 2005, Biochimica et biophysica acta.
[37] A. Pitt,et al. Development of novel mass spectrometric methods for identifying HOCl‐induced modifications to proteins , 2009, Proteomics.
[38] S. Burman,et al. Facile method of quantification for oxidized tryptophan degradants of monoclonal antibody by mixed mode ultra performance liquid chromatography. , 2012, Journal of chromatography. A.
[39] R. Bass,et al. N-terminal Glutamate to Pyroglutamate Conversion in Vivo for Human IgG2 Antibodies , 2011, The Journal of Biological Chemistry.
[40] Douglas S Rehder,et al. Identification and characterization of deamidation sites in the conserved regions of human immunoglobulin gamma antibodies. , 2005, Analytical chemistry.
[41] N. Viner,et al. Cell Recognition of the Dominant I-A k – restricted Hen Egg Lysozyme Epitope : Critical Role for Asparagine Deamidation , 2001 .
[42] R. Vachet,et al. Improved sequencing of oxidized cysteine and methionine containing peptides using electron transfer dissociation , 2007, Journal of the American Society for Mass Spectrometry.
[43] John M. Lambert,et al. Structural Characterization of a Recombinant Monoclonal Antibody by Electrospray Time-of-Flight Mass Spectrometry , 2005, Pharmaceutical Research.
[44] Chung C. Hsu,et al. Site-Specific Tryptophan Oxidation Induced by Autocatalytic Reaction of Polysorbate 20 in Protein Formulation , 2011, Pharmaceutical Research.
[45] P. Bondarenko,et al. Screening and sequencing of glycated proteins by neutral loss scan LC/MS/MS method. , 2007, Analytical chemistry.
[46] Hongcheng Liu,et al. Method to differentiate asn deamidation that occurred prior to and during sample preparation of a monoclonal antibody. , 2008, Analytical chemistry.
[47] S. L. Smith. Ten years of Orthoclone OKT3 (muromonab-CD3): a review. , 1996, Journal of transplant coordination : official publication of the North American Transplant Coordinators Organization.
[48] Scott A. McLuckey,et al. Differentiation of aspartic and isoaspartic acids using electron transfer dissociation , 2006, Journal of the American Society for Mass Spectrometry.
[49] N. Bihoreau,et al. Fast analysis of recombinant monoclonal antibodies using IdeS proteolytic digestion and electrospray mass spectrometry. , 2011, Analytical biochemistry.
[50] M. Murata,et al. Identification of N(omega)-carboxymethylarginine as a novel acid-labileadvanced glycation end product in collagen. , 2000, The Biochemical journal.
[51] Richard D. Smith,et al. Enrichment and analysis of nonenzymatically glycated peptides: boronate affinity chromatography coupled with electron-transfer dissociation mass spectrometry. , 2007, Journal of proteome research.
[52] A. Safavy,et al. Synthesis and preliminary biological evaluation of high-drug-load paclitaxel-antibody conjugates for tumor-targeted chemotherapy. , 2010, Journal of medicinal chemistry.
[53] Tilman Schlothauer,et al. Assessment of chemical modifications of sites in the CDRs of recombinant antibodies , 2014, mAbs.
[54] A. Lim,et al. Applications of mass spectrometry for the structural characterization of recombinant protein pharmaceuticals. , 2007, Mass spectrometry reviews.
[55] V. Katta,et al. Rapid identification of low level glycation sites in recombinant antibodies by isotopic labeling with 13C6-reducing sugars. , 2012, Analytical chemistry.
[56] C. Wasternack,et al. Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution , 2008, Biological chemistry.
[57] C. Szpirer,et al. Primary Structure, Tissue Distribution, and Chromosomal Localization of a Novel Isoform of Lysyl Hydroxylase (Lysyl Hydroxylase 3)* , 1998, The Journal of Biological Chemistry.
[58] Andreas Rizzi,et al. Analysis of lysine clipping of a humanized Lewis-Y specific IgG antibody and its relation to Fc-mediated effector function. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[59] Reed J. Harris,et al. Non-enzymatic hinge region fragmentation of antibodies in solution. , 2005, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[60] Sylvie Garneau-Tsodikova,et al. Protein posttranslational modifications: the chemistry of proteome diversifications. , 2005, Angewandte Chemie.
[61] R. Hoffmann,et al. Mass spectrometric characterization of peptides containing different oxidized tryptophan residues. , 2011, Journal of mass spectrometry : JMS.
[62] J. Hong,et al. Metal-catalyzed Oxidation of Histidine in Human Growth Hormone , 1997, The Journal of Biological Chemistry.
[63] V. Katta,et al. Structural characterization of intact antibodies by high-resolution LTQ Orbitrap mass spectrometry. , 2009, Journal of mass spectrometry : JMS.
[64] Steven J. Shire,et al. Commercial manufacturing scale formulation and analytical characterization of therapeutic recombinant antibodies , 2004 .
[65] Ron Taticek,et al. A study in glycation of a therapeutic recombinant humanized monoclonal antibody: where it is, how it got there, and how it affects charge-based behavior. , 2008, Analytical biochemistry.
[66] D. Aswad,et al. In vitro aging of calmodulin generates isoaspartate at multiple Asn–Gly and Asp–Gly sites in calcium‐binding domains II, III, and IV , 1993, Protein science : a publication of the Protein Society.
[67] G Shimamoto,et al. Chemical modification and site-directed mutagenesis of methionine residues in recombinant human granulocyte colony-stimulating factor: effect on stability and biological activity. , 1999, Archives of biochemistry and biophysics.
[68] R. Weindruch,et al. Ageing, oxidative stress, and mitochondrial uncoupling. , 2004, Acta physiologica Scandinavica.
[69] Rahul S Rajan,et al. Formation of pyroglutamic acid from N-terminal glutamic acid in immunoglobulin gamma antibodies. , 2006, Analytical chemistry.
[70] R. Nissi,et al. Prolyl 4-Hydroxylase , 2003 .
[71] S. Stroop. A modified peptide mapping strategy for quantifying site-specific deamidation by electrospray time-of-flight mass spectrometry. , 2007, Rapid communications in mass spectrometry : RCM.
[72] Ronald T Borchardt,et al. Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies. , 2007, Biochemistry.
[73] A. B. Robinson,et al. Deamidation of glutaminyl residues: dependence on pH, temperature, and ionic strength. , 1974, Analytical biochemistry.
[74] Rashmi Kshirsagar,et al. Characterization of trisulfide modification in antibodies. , 2010, Analytical biochemistry.
[75] Y John Wang,et al. Methionine, tryptophan, and histidine oxidation in a model protein, PTH: mechanisms and stabilization. , 2009, Journal of pharmaceutical sciences.
[76] Hongcheng Liu,et al. Heterogeneity of monoclonal antibodies. , 2008, Journal of pharmaceutical sciences.
[77] J. Cleland,et al. Comparison Between Light Induced and Chemically Induced Oxidation of rhVEGF , 2001, Pharmaceutical Research.
[78] A. B. Robinson,et al. Rates of nonenzymatic deamidation of glutaminyl and asparaginyl residues in pentapeptides. , 1973, Journal of the American Chemical Society.
[79] D. Chelius,et al. 18O labeling method for identification and quantification of succinimide in proteins. , 2007, Analytical chemistry.
[80] Bernhardt L Trout,et al. Asparagine deamidation: pH-dependent mechanism from density functional theory. , 2006, Biochemistry.
[81] A. Sickmann,et al. Application of electron transfer dissociation (ETD) for the analysis of posttranslational modifications , 2008, Proteomics.
[82] W. Xu,et al. Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies , 2012, mAbs.
[83] Li Zang,et al. Residual metals cause variability in methionine oxidation measurements in protein pharmaceuticals using LC-UV/MS peptide mapping. , 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[84] D. Aswad,et al. Optimal conditions for the use of protein L-isoaspartyl methyltransferase in assessing the isoaspartate content of peptides and proteins. , 1991, Analytical biochemistry.
[85] C. Damen,et al. Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab , 2009, Journal of the American Society for Mass Spectrometry.
[86] Y. Kawata,et al. Chemical modification of tryptophan residues and stability changes in proteins. , 1990, Biochemistry.
[87] Ziping Wei,et al. Characterization of a novel modification to monoclonal antibodies: thioether cross-link of heavy and light chains. , 2005, Analytical chemistry.
[88] S. Arena,et al. Modern proteomic methodologies for the characterization of lactosylation protein targets in milk , 2010, Proteomics.
[89] Jun Liu,et al. Effect of individual Fc methionine oxidation on FcRn binding: Met252 oxidation impairs FcRn binding more profoundly than Met428 oxidation. , 2015, Journal of pharmaceutical sciences.
[90] Prabha Dwivedi,et al. Ion mobility-mass spectrometry. , 2008, Journal of mass spectrometry : JMS.
[91] W. Ens,et al. Deamidation of -Asn-Gly- sequences during sample preparation for proteomics: Consequences for MALDI and HPLC-MALDI analysis. , 2006, Analytical chemistry.
[92] Wei Wang,et al. Peroxide formation in polysorbate 80 and protein stability. , 2002, Journal of pharmaceutical sciences.
[93] Domenico Fedele,et al. Enzymatic digestion and mass spectrometry in the study of advanced glycation end products/peptides , 2004, Journal of the American Society for Mass Spectrometry.
[94] Sol Ruiz,et al. Development and Regulation of Biosimilars: Current Status and Future Challenges , 2013, BioDrugs.
[95] J. Baynes,et al. Glycation of amino groups in protein. Studies on the specificity of modification of RNase by glucose. , 1985, The Journal of biological chemistry.
[96] J. Whitelegge. Intact protein mass spectrometry and top-down proteomics , 2013, Expert review of proteomics.
[97] Hongcheng Liu,et al. Identification and comparative quantitation of glycation by stable isotope labeling and LC-MS. , 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[98] Michael Schrader,et al. Peroxisomes and oxidative stress. , 2006, Biochimica et biophysica acta.
[99] Hanns-Christian Mahler,et al. Forced degradation of therapeutic proteins. , 2012, Journal of pharmaceutical sciences.
[100] J. Shabanowitz,et al. Cutting edge: the HLA-A*0101-restricted HY minor histocompatibility antigen originates from DFFRY and contains a cysteinylated cysteine residue as identified by a novel mass spectrometric technique. , 1999, Journal of immunology.
[101] Hong Liu. Study of Glycation and Advanced Glycation on a Humanized Monoclonal Antibody , 2013 .
[102] D. Chelius,et al. Accumulation of Succinimide in a Recombinant Monoclonal Antibody in Mildly Acidic Buffers Under Elevated Temperatures , 2007, Pharmaceutical Research.
[103] M. van de Weert,et al. Identification of oxidized methionine in peptides. , 1996, Rapid communications in mass spectrometry : RCM.
[104] Ronald J. Moore,et al. Application of pressurized solvents for ultrafast trypsin hydrolysis in proteomics: proteomics on the fly. , 2008, Journal of proteome research.
[105] Jun Luo,et al. Probing of C‐terminal lysine variation in a recombinant monoclonal antibody production using Chinese hamster ovary cells with chemically defined media , 2012, Biotechnology and bioengineering.
[106] Hui Zhao,et al. Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form. , 2009, Journal of pharmaceutical sciences.
[107] P. Roller,et al. Cyclization strategies in peptide derived drug design. , 2002, Current topics in medicinal chemistry.
[108] Jennifer M. Campbell,et al. Matrix‐assisted laser desorption/ionization‐tandem mass spectrometry with high resolution and sensitivity for identification and characterization of proteins , 2002, Proteomics.
[109] A. Goloborodko,et al. Sequence‐specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides , 2011, Electrophoresis.
[110] M. Donbrow,et al. Autoxidation of polysorbates. , 1978, Journal of pharmaceutical sciences.
[111] A. Beck,et al. Advantages of extended bottom-up proteomics using Sap9 for analysis of monoclonal antibodies. , 2014, Analytical chemistry.
[112] E. Stadtman,et al. Oxidation of free amino acids and amino acid residues in proteins by radiolysis and by metal-catalyzed reactions. , 1993, Annual review of biochemistry.
[113] Xianglin Shi,et al. The role of oxygen free radicals in occupational and environmental lung diseases. , 1997, Environmental health perspectives.
[114] J. M. Beals,et al. In vivo deamidation characterization of monoclonal antibody by LC/MS/MS. , 2005, Analytical chemistry.
[115] M. Davies,et al. Generation and propagation of radical reactions on proteins. , 2001, Biochimica et biophysica acta.
[116] Kiichi Fukui,et al. Detection of histidine oxidation in a monoclonal immunoglobulin gamma (IgG) 1 antibody. , 2014, Analytical chemistry.
[117] L. Presta,et al. Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity. , 1996, Biochemistry.
[118] Larissa S Fenn,et al. Structural separations by ion mobility-MS for glycomics and glycoproteomics. , 2013, Methods in molecular biology.
[119] L. Khawli,et al. Charge variants in IgG1 , 2010, mAbs.
[120] R. Borchardt,et al. Effects of acidic N + 1 residues on asparagine deamidation rates in solution and in the solid state. , 2005, Journal of pharmaceutical sciences.
[121] Inn Yuk,et al. Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody. , 2008, Analytical chemistry.
[122] J. Beijnen,et al. Analytical techniques used to study the degradation of proteins and peptides: chemical instability. , 1998, Journal of pharmaceutical and biomedical analysis.
[123] C. Schneider,et al. Setting the stage for biosimilar monoclonal antibodies , 2012, Nature Biotechnology.
[124] Liying Wang,et al. Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity , 2013, BioMed research international.
[125] S. Clarke,et al. Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation. , 1987, The Journal of biological chemistry.
[126] D. Gjerde,et al. Enrichment of Amadori products derived from the nonenzymatic glycation of proteins using microscale boronate affinity chromatography. , 2009, Analytical biochemistry.
[127] L. Łankiewicz,et al. Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1-10, 1-16 fragments of human and mouse beta-amyloid peptide. , 2004, Journal of inorganic biochemistry.
[128] Gang Huang,et al. Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn , 2009, Protein science : a publication of the Protein Society.
[129] Alain Van Dorsselaer,et al. Characterization by liquid chromatography combined with mass spectrometry of monoclonal anti-IGF-1 receptor antibodies produced in CHO and NS0 cells. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[130] R. Zubarev,et al. Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides , 2010, Electrophoresis.
[131] R. Rink,et al. To protect peptide pharmaceuticals against peptidases. , 2010, Journal of pharmacological and toxicological methods.
[132] Hongcheng Liu,et al. Accurate determination of protein methionine oxidation by stable isotope labeling and LC-MS analysis. , 2013, Analytical chemistry.
[133] C. Quan,et al. Susceptibility of rhDNase I to glycation in the dry-powder state. , 1999, Analytical chemistry.
[134] L Renee Ruhaak,et al. Oligosaccharide analysis by mass spectrometry: a review of recent developments. , 2014, Analytical chemistry.
[135] Hongcheng Liu,et al. Structural effect of deglycosylation and methionine oxidation on a recombinant monoclonal antibody. , 2008, Molecular immunology.
[136] R Tyler-Cross,et al. Effects of amino acid sequence, buffers, and ionic strength on the rate and mechanism of deamidation of asparagine residues in small peptides. , 1991, The Journal of biological chemistry.
[137] Yang Wang,et al. Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. , 2011, Molecular immunology.
[138] Identification of deamidation and isomerization sites on pharmaceutical recombinant antibody using H(2)(18)O. , 2007, Analytical biochemistry.
[139] J. Moss,et al. Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity. , 2000, The Journal of biological chemistry.
[140] Cheng Lin,et al. Quantitating the relative abundance of isoaspartyl residues in deamidated proteins by electron capture dissociation , 2007, Journal of the American Society for Mass Spectrometry.
[141] Analysis of deamidation artifacts induced by microwave-assisted tryptic digestion of a monoclonal antibody , 2014, Analytical and Bioanalytical Chemistry.
[142] J. Bonfield,et al. Finishing the euchromatic sequence of the human genome , 2004, Nature.
[143] Huilin Li,et al. Native top-down electrospray ionization-mass spectrometry of 158 kDa protein complex by high-resolution Fourier transform ion cyclotron resonance mass spectrometry. , 2014, Analytical chemistry.
[144] Wei Zhang,et al. Analysis of isoaspartate in a recombinant monoclonal antibody and its charge isoforms. , 2003, Journal of pharmaceutical and biomedical analysis.
[145] Thomayant Prueksaritanont,et al. Impact of methionine oxidation on the binding of human IgG1 to Fc Rn and Fc gamma receptors. , 2009, Molecular immunology.
[146] Cheng Lin,et al. Use of 18O labels to monitor deamidation during protein and peptide sample processing , 2008, Journal of the American Society for Mass Spectrometry.
[147] Shibdas Banerjee,et al. Electrospray Ionization Mass Spectrometry: A Technique to Access the Information beyond the Molecular Weight of the Analyte , 2011, International journal of analytical chemistry.
[148] B. Kabakoff,et al. Identification of multiple sources of charge heterogeneity in a recombinant antibody. , 2001, Journal of chromatography. B, Biomedical sciences and applications.
[149] S. Leigh,et al. Photosensitizers form in histidine buffer and mediate the photodegradation of a monoclonal antibody. , 2011, Journal of pharmaceutical sciences.
[150] T. Kislinger,et al. Qualitative determination of specific protein glycation products by matrix-assisted laser desorption/ionization mass spectrometry Peptide mapping. , 2002, Journal of agricultural and food chemistry.
[151] A. Acharya,et al. Amadori rearrangement potential of hemoglobin at its glycation sites is dependent on the three-dimensional structure of protein. , 1992, Biochemistry.
[152] H. Wright. Sequence and structure determinants of the nonenzymatic deamidation of asparagine and glutamine residues in proteins. , 1991, Protein engineering.
[153] R. Flückiger,et al. Nonenzymatic glycosylation of albumin in vivo. Identification of multiple glycosylated sites. , 1986, The Journal of biological chemistry.
[154] R. Bischoff,et al. Electrochemical oxidation and cleavage of tyrosine- and tryptophan-containing tripeptides. , 2010, Analytical chemistry.
[155] Andrew M Goetze,et al. Rates and impact of human antibody glycation in vivo. , 2012, Glycobiology.
[156] N. Vijayasankaran,et al. Controlling glycation of recombinant antibody in fed‐batch cell cultures , 2011, Biotechnology and bioengineering.
[157] S. Sanglier-Cianférani,et al. Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: characterization of immune complexes using noncovalent ESI-MS. , 2009, Analytical chemistry.
[158] C. Dutertre,et al. Activating and inhibitory Fcγ receptors in immunotherapy: being the actor or being the target , 2009, Expert review of clinical immunology.
[159] Richard D. Smith,et al. An integrated top-down and bottom-up strategy for broadly characterizing protein isoforms and modifications. , 2009, Journal of proteome research.
[160] P. Schnier,et al. Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry. , 2010, Analytical chemistry.
[161] T. Ryll,et al. Controlling trisulfide modification in recombinant monoclonal antibody produced in fed‐batch cell culture , 2012, Biotechnology and bioengineering.
[162] Wei Wang,et al. Factors affecting cleavage at aspartic residues in model decapeptides. , 2009, Journal of pharmaceutical and biomedical analysis.
[163] H. Steinhart,et al. Oxidation of Free Tryptophan and Tryptophan Residues in Peptides and Proteins. , 1998, Journal of agricultural and food chemistry.
[164] Margit Jeschke,et al. Determination of the Origin of Charge Heterogeneity in a Murine Monoclonal Antibody , 2000, Pharmaceutical Research.
[165] Richard D. Smith,et al. Application of electron transfer dissociation mass spectrometry in analyses of non-enzymatically glycated peptides. , 2007, Rapid communications in mass spectrometry : RCM.
[166] E. Randell,et al. Plasma protein advanced glycation end products, carboxymethyl cysteine, and carboxyethyl cysteine, are elevated and related to nephropathy in patients with diabetes , 2007, Molecular and Cellular Biochemistry.
[167] G. Biggio,et al. Biosimilar Drugs , 2012, BioDrugs.
[168] M. Weert,et al. Mass spectrometric analysis of oxidized tryptophan , 1998 .
[169] Cheng Lin,et al. Detecting deamidation products in proteins by electron capture dissociation. , 2006, Analytical chemistry.
[170] Liang-Yu Shih,et al. An improved trypsin digestion method minimizes digestion-induced modifications on proteins. , 2009, Analytical biochemistry.
[171] N. Neumann. [31] Oxidation with hydrogen peroxide. , 1972, Methods in enzymology.
[172] E. C. Beuvery,et al. Analytical Approaches to the Study of Monoclonal Antibody Stability , 1990, Pharmaceutical Research.
[173] Zhongqi Zhang,et al. Large-scale identification and quantification of covalent modifications in therapeutic proteins. , 2009, Analytical chemistry.
[174] Da Ren,et al. Structure and stability changes of human IgG1 Fc as a consequence of methionine oxidation. , 2008, Biochemistry.
[175] Steven L. Cohen,et al. Beta-elimination and peptide bond hydrolysis: two distinct mechanisms of human IgG1 hinge fragmentation upon storage. , 2007, Journal of the American Chemical Society.
[176] Z. Szewczuk,et al. Selective Detection of Carbohydrates and Their Peptide Conjugates by ESI-MS Using Synthetic Quaternary Ammonium Salt Derivatives of Phenylboronic Acids , 2014, Journal of The American Society for Mass Spectrometry.
[177] O. Jensen. Modification-specific proteomics: characterization of post-translational modifications by mass spectrometry. , 2004, Current opinion in chemical biology.
[178] Margaret Ricci,et al. The LC/MS analysis of glycation of IgG molecules in sucrose containing formulations. , 2007, Journal of pharmaceutical sciences.
[179] Surendra Dasari,et al. Quantification of isotopically overlapping deamidated and 18o-labeled peptides using isotopic envelope mixture modeling. , 2009, Journal of proteome research.
[180] D. Creasy,et al. Unimod: Protein modifications for mass spectrometry , 2004, Proteomics.
[181] A. Raghani,et al. Analysis of monoclonal antibody product heterogeneity resulting from alternate cleavage sites of signal peptide. , 2010, Analytical biochemistry.
[182] Andreas Petzold,et al. Identification of Potential Sites for Tryptophan Oxidation in Recombinant Antibodies Using tert-Butylhydroperoxide and Quantitative LC-MS , 2011, PloS one.
[183] J. Farber,et al. Mechanisms of cell injury by activated oxygen species. , 1994, Environmental health perspectives.
[184] Hongcheng Liu,et al. Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[185] L. Waskell,et al. Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation , 2005, Protein science : a publication of the Protein Society.
[186] B. Kerwin,et al. A Quantitative Kinetic Study of Polysorbate Autoxidation: The Role of Unsaturated Fatty Acid Ester Substituents , 2009, Pharmaceutical Research.
[187] B. Shilton,et al. Sites of glycation of human and horse liver alcohol dehydrogenase in vivo. , 1991, The Journal of biological chemistry.
[188] François Debaene,et al. Time resolved native ion-mobility mass spectrometry to monitor dynamics of IgG4 Fab arm exchange and "bispecific" monoclonal antibody formation. , 2013, Analytical chemistry.
[189] A. Marshall,et al. Top-down structural analysis of an intact monoclonal antibody by electron capture dissociation-Fourier transform ion cyclotron resonance-mass spectrometry. , 2013, Analytical chemistry.
[190] S. Arena,et al. Non-enzymatic glycation and glycoxidation protein products in foods and diseases: an interconnected, complex scenario fully open to innovative proteomic studies. , 2014, Mass spectrometry reviews.
[191] J. Capelo,et al. Ultra fast trypsin digestion of proteins by high intensity focused ultrasound. , 2005, Journal of proteome research.
[192] L. Deterding,et al. Mass spectrometric identification of oxidative modifications of tryptophan residues in proteins: Chemical artifact or post-translational modification? , 2010, Journal of the American Society for Mass Spectrometry.
[193] Ralf Hoffmann,et al. Arginine-derived advanced glycation end products generated in peptide-glucose mixtures during boiling. , 2014, Journal of agricultural and food chemistry.
[194] T. Kislinger,et al. Analysis of Protein Glycation Products by MALDI‐TOF/MS , 2005, Annals of the New York Academy of Sciences.
[195] Douglas S Rehder,et al. Reversed-phase liquid chromatography/mass spectrometry analysis of reduced monoclonal antibodies in pharmaceutics. , 2006, Journal of chromatography. A.
[196] T. H. Nguyen,et al. Aggregation and precipitation of human relaxin induced by metal-catalyzed oxidation. , 1995, Biochemistry.
[197] Robert Gurny,et al. Stability of human growth hormone: influence of methionine oxidation on thermal folding. , 2011, Journal of pharmaceutical sciences.
[198] John F. Valliere-Douglass,et al. Molecular mass analysis of antibodies by on-line SEC-MS , 2008, Journal of the American Society for Mass Spectrometry.
[199] C. Milstein,et al. Continuous cultures of fused cells secreting antibody of predefined specificity , 1975, Nature.
[200] F. Weygand,et al. Die Amadori‐Umlagerung , 1937 .
[201] Difei Qiu,et al. C‐terminal lysine variants in fully human monoclonal antibodies: Investigation of test methods and possible causes , 2008, Biotechnology and bioengineering.
[202] R. Borchardt,et al. Chemical Pathways of Peptide Degradation. IV. Pathways, Kinetics, and Mechanism of Degradation of an Aspartyl Residue in a Model Hexapeptide , 2004, Pharmaceutical Research.
[203] Zhongqi Zhang,et al. LC-MS/MS Peptide Mapping with Automated Data Processing for Routine Profiling of N-Glycans in Immunoglobulins , 2014, Journal of The American Society for Mass Spectrometry.
[204] K. Gevaert,et al. Protein processing and other modifications analyzed by diagonal peptide chromatography. , 2006, Biochimica et biophysica acta.
[205] Ziping Wei,et al. Identification of a single tryptophan residue as critical for binding activity in a humanized monoclonal antibody against respiratory syncytial virus. , 2007, Analytical chemistry.
[206] Aditya A Wakankar,et al. The effect of cosolutes on the isomerization of aspartic acid residues and conformational stability in a monoclonal antibody. , 2007, Journal of pharmaceutical sciences.
[207] R. Townsend,et al. Identification, quantification, and characterization of glycopeptides in reversed-phase HPLC separations of glycoprotein proteolytic digests. , 1993, Analytical biochemistry.
[208] P. Livne,et al. Medium-Term Follow-Up of Children with Unilateral Non or Poorly Functioning Kidney: A Single-Center Experience , 2013 .
[209] Manfred Nimtz,et al. Sequencing of tri- and tetraantennary N-glycans containing sialic acid by negative mode ESI QTOF tandem MS , 2002, Journal of the American Society for Mass Spectrometry.
[210] Hongcheng Liu,et al. Arginine modifications by methylglyoxal: discovery in a recombinant monoclonal antibody and contribution to acidic species. , 2013, Analytical chemistry.
[211] D. Aswad,et al. Isoaspartate in peptides and proteins: formation, significance, and analysis. , 2000, Journal of pharmaceutical and biomedical analysis.
[212] P. Edwards. Some properties and applications of monoclonal antibodies. , 1981, The Biochemical journal.
[213] Hongcheng Liu,et al. Glutamine deamidation of a recombinant monoclonal antibody. , 2008, Rapid communications in mass spectrometry : RCM.