Pregnancy‐Associated Uterine Granulated Metrial Gland Cells in Mutant and Transgenic Mice

PROBLEM: Granulated metrial gland (GMG) cells are pregnancy‐specific uterine lymphocytes found in rodents. The lineage relationships of GMG cells are incompletely defined, although genetic and immunophenotyping studies suggest membership in the natural killer (NIC) cell lineage. Pregnancy‐specific functions have been postulated for GMG cells, but no successful depletion of these cells has been achieved that would permit assessment of any critical roles that might influence gestational outcome.

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