Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks
暂无分享,去创建一个
Mariano J. Alvarez | K. Aldape | A. Califano | M. Alvarez | K. Diefes | James C. Chen | F. Talos | Harshil Dhruv | G. Rieckhof | A. Iyer | M. Berens | M. Shen
[1] Mariano J. Alvarez,et al. Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy. , 2014, Cancer cell.
[2] Anne E Carpenter,et al. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. , 2014, Cell reports.
[3] Andrea Califano,et al. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. , 2013, Cancer cell.
[4] D. Haussler,et al. The Somatic Genomic Landscape of Glioblastoma , 2013, Cell.
[5] D. Pe’er,et al. RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation. , 2013, Cancer research.
[6] Raul Rabadan,et al. The integrated landscape of driver genomic alterations in glioblastoma , 2013, Nature Genetics.
[7] Steven A. Roberts,et al. Mutational heterogeneity in cancer and the search for new cancer genes , 2014 .
[8] L. Tran,et al. Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease , 2013, Cell.
[9] David Tamborero,et al. Oncodrive-CIS: A Method to Reveal Likely Driver Genes Based on the Impact of Their Copy Number Changes on Expression , 2013, PloS one.
[10] Huaxi Xu,et al. Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy , 2013, Nature Reviews Neurology.
[11] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumours , 2013 .
[12] Steven A. Roberts,et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes , 2013 .
[13] A. Butte,et al. Leveraging models of cell regulation and GWAS data in integrative network-based association studies , 2012, Nature Genetics.
[14] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumors , 2012, Nature.
[15] Andrea Califano,et al. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL , 2011, Nature Medicine.
[16] Xuerui Yang,et al. An Extensive MicroRNA-Mediated Network of RNA-RNA Interactions Regulates Established Oncogenic Pathways in Glioblastoma , 2011, Cell.
[17] Andrea Califano,et al. The TLX1 oncogene drives aneuploidy in T-cell transformation , 2010, Nature Medicine.
[18] Benito Munoz,et al. Towards patient-based cancer therapeutics , 2010, Nature Biotechnology.
[19] Mariano J. Alvarez,et al. A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers , 2010, Molecular systems biology.
[20] J. Uhm,et al. The transcriptional network for mesenchymal transformation of brain tumours , 2010 .
[21] Yuan Qi,et al. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH 1 , EGFR , and NF 1 Citation Verhaak , 2010 .
[22] Mariano J. Alvarez,et al. Genome-wide Identification of Post-translational Modulators of Transcription Factor Activity in Human B-Cells , 2009, Nature Biotechnology.
[23] Wei Keat Lim,et al. The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain. , 2009, Developmental cell.
[24] R. Dalla‐Favera,et al. Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma , 2009, Nature.
[25] Ji Luo,et al. Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction , 2009, Cell.
[26] Wei Keat Lim,et al. Master Regulators Used As Breast Cancer Metastasis Classifier , 2008, Pacific Symposium on Biocomputing.
[27] Joshua M. Korn,et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways , 2008, Nature.
[28] A. Ferrando,et al. The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia , 2007, The Journal of experimental medicine.
[29] G. Sumara,et al. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. , 2007, Developmental cell.
[30] K. Nakayama,et al. Ubiquitin ligases: cell-cycle control and cancer , 2006, Nature Reviews Cancer.
[31] Jayant P. Menon,et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. , 2006, Cancer cell.
[32] Thomas D. Wu,et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. , 2006, Cancer cell.
[33] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[34] P. Kleihues,et al. Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. , 2005, Journal of neuropathology and experimental neurology.
[35] Adam A. Margolin,et al. Reverse engineering of regulatory networks in human B cells , 2005, Nature Genetics.
[36] R. Stern,et al. Establishment and characterization of five cell lines derived from human malignant gliomas , 2004, Acta Neuropathologica.
[37] S. Elledge,et al. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3 , 2003, Nature.
[38] J. Thiery. Epithelial–mesenchymal transitions in tumour progression , 2002, Nature Reviews Cancer.
[39] Ulrich Siebenlist,et al. Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells , 2001, The Journal of experimental medicine.