LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis

[1]  Alissa M. Weaver,et al.  Regulation of invadopodia by mechanical signaling. , 2016, Experimental cell research.

[2]  J. Lewis,et al.  Invadopodia: a new therapeutic target to block cancer metastasis , 2015, Expert review of anticancer therapy.

[3]  Yan-wen Yao,et al.  PTP1B promotes cell proliferation and metastasis through activating src and ERK1/2 in non-small cell lung cancer. , 2015, Cancer letters.

[4]  W. You,et al.  The Invadopodia Scaffold Protein Tks5 Is Required for the Growth of Human Breast Cancer Cells In Vitro and In Vivo , 2015, PloS one.

[5]  P. Siegel,et al.  Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis , 2015, Oncotarget.

[6]  L. Primo,et al.  Podosomes and invadopodia: tools to breach vascular basement membrane , 2015, Cell cycle.

[7]  W. Miller,et al.  Genetic and pharmacologic inhibition of eIF4E reduces breast cancer cell migration, invasion, and metastasis. , 2015, Cancer research.

[8]  B. Fabry,et al.  Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks. , 2015, Acta biomaterialia.

[9]  Bojana Gligorijevic,et al.  Multiparametric Classification Links Tumor Microenvironments with Tumor Cell Phenotype , 2014, PLoS biology.

[10]  J. Condeelis,et al.  Digging a little deeper: the stages of invadopodium formation and maturation. , 2014, European journal of cell biology.

[11]  Amy E. Robertson,et al.  Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis. , 2014, Cell reports.

[12]  J. Yang,et al.  Invading one step at a time: the role of invadopodia in tumor metastasis , 2014, Oncogene.

[13]  B. Geiger,et al.  The interplay between the proteolytic, invasive, and adhesive domains of invadopodia and their roles in cancer invasion , 2014, Cell adhesion & migration.

[14]  S. Tsuboi,et al.  Extravasation during bladder cancer metastasis requires cortactin‑mediated invadopodia formation. , 2014, Molecular medicine reports.

[15]  Bojana Gligorijevic,et al.  Invadopodia in context , 2014, Cell adhesion & migration.

[16]  Soo Young Lee,et al.  Soft matrix is a natural stimulator for cellular invasiveness , 2014, Molecular biology of the cell.

[17]  A. Bershadsky,et al.  Integrin-Matrix Clusters Form Podosome-like Adhesions in the Absence of Traction Forces , 2013, Cell reports.

[18]  Jaykaran Charan,et al.  How to calculate sample size in animal studies? , 2013, Journal of pharmacology & pharmacotherapeutics.

[19]  S. Boateng,et al.  Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis. , 2013, American journal of physiology. Heart and circulatory physiology.

[20]  Claire M Brown,et al.  A complex containing LPP and &agr;-actinin mediates TGF&bgr;-induced migration and invasion of ErbB2-expressing breast cancer cells , 2013, Journal of Cell Science.

[21]  T. Pawson,et al.  Distinct Phosphotyrosine-dependent Functions of the ShcA Adaptor Protein Are Required for Transforming Growth Factor β (TGFβ)-induced Breast Cancer Cell Migration, Invasion, and Metastasis* , 2012, The Journal of Biological Chemistry.

[22]  H. Yamaguchi.  Pathological roles of invadopodia in cancer invasion and metastasis. , 2012, European journal of cell biology.

[23]  G. Danuser,et al.  Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility , 2012, The Journal of cell biology.

[24]  Alissa M. Weaver,et al.  Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis , 2012, Science Signaling.

[25]  M. Tremblay,et al.  Met receptor tyrosine kinase signals through a cortactin–Gab1 scaffold complex, to mediate invadopodia , 2012, Journal of Cell Science.

[26]  Alissa M. Weaver,et al.  Adhesion rings surround invadopodia and promote maturation , 2012, Biology Open.

[27]  C. Turner,et al.  Hic-5 promotes invadopodia formation and invasion during TGF-b–induced epithelial–mesenchymal transition , 2012 .

[28]  C. Turner,et al.  Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition , 2012, The Journal of cell biology.

[29]  R. Bose,et al.  Identification of Targets of c-Src Tyrosine Kinase by Chemical Complementation and Phosphoproteomics* , 2012, Molecular & Cellular Proteomics.

[30]  W. Muller,et al.  Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo , 2012, Breast Cancer Research.

[31]  M. McNiven,et al.  Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex , 2012, The Journal of cell biology.

[32]  J. Condeelis,et al.  N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors , 2012, Journal of Cell Science.

[33]  S. Courtneidge,et al.  The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function , 2011, Nature Reviews Molecular Cell Biology.

[34]  Jing Yang,et al.  Targeting invadopodia to block breast cancer metastasis , 2011, Oncotarget.

[35]  W. Muller,et al.  Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis , 2011, Proceedings of the National Academy of Sciences.

[36]  John R. Yates,et al.  Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation , 2011, Nature Cell Biology.

[37]  Thinzar M. Lwin,et al.  Twist1-induced invadopodia formation promotes tumor metastasis. , 2011, Cancer cell.

[38]  J. Condeelis,et al.  An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. , 2011, Cancer research.

[39]  Alissa M. Weaver,et al.  Sensing and modulation of invadopodia across a wide range of rigidities. , 2011, Biophysical journal.

[40]  David R. Croucher,et al.  Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. , 2010, Cancer research.

[41]  Robert D. Goldman,et al.  Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia , 2010, The Journal of cell biology.

[42]  H. Cooper,et al.  Differential Phosphoproteomics of Fibroblast Growth Factor Signaling: Identification of Src Family Kinase-Mediated Phosphorylation Events , 2010, Journal of proteome research.

[43]  John C. Dawson,et al.  The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion , 2010, Current Biology.

[44]  C. Billottet,et al.  TGFβ-induced endothelial podosomes mediate basement membrane collagen degradation in arterial vessels , 2009, Journal of Cell Science.

[45]  E. Erdfelder,et al.  Statistical power analyses using G*Power 3.1: Tests for correlation and regression analyses , 2009, Behavior research methods.

[46]  O. Destaing,et al.  Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions , 2009, Journal of Cell Science.

[47]  Saskia M Pasedag,et al.  Cell Adhesion and Transcriptional Activity - Defining the Role of the Novel Protooncogene LPP. , 2009, Translational oncology.

[48]  R. Buccione,et al.  Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix , 2009, Cancer and Metastasis Reviews.

[49]  Keith R. Johnson,et al.  TGF-beta induces formation of F-actin cores and matrix degradation in human breast cancer cells via distinct signaling pathways. , 2008, Experimental cell research.

[50]  Scott A. Guelcher,et al.  Extracellular Matrix Rigidity Promotes Invadopodia Activity , 2008, Current Biology.

[51]  M. Mann,et al.  Investigation of Protein-tyrosine Phosphatase 1B Function by Quantitative Proteomics*S , 2008, Molecular & Cellular Proteomics.

[52]  A. Pandey,et al.  Global impact of oncogenic Src on a phosphotyrosine proteome. , 2008, Journal of proteome research.

[53]  T. Pawson,et al.  ShcA signalling is essential for tumour progression in mouse models of human breast cancer , 2008, The EMBO journal.

[54]  A. Huttenlocher,et al.  Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion , 2008, The Journal of cell biology.

[55]  W. Muller,et al.  Signaling through ShcA Is Required for Transforming Growth Factor β- and Neu/ErbB-2-Induced Breast Cancer Cell Motility and Invasion , 2008, Molecular and Cellular Biology.

[56]  Alissa M. Weaver,et al.  Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia. , 2007, Cancer research.

[57]  B. Kennedy,et al.  Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis , 2007, Nature Genetics.

[58]  Rebecca Slack,et al.  Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. , 2006, Experimental cell research.

[59]  M. Majesky.  Organizing motility: LIM domains, LPP, and smooth muscle migration. , 2006, Circulation research.

[60]  J. Resau,et al.  The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. , 2005, Cancer cell.

[61]  J. Segall,et al.  Molecular mechanisms of invadopodium formation , 2005, The Journal of cell biology.

[62]  J. Rush,et al.  Immunoaffinity profiling of tyrosine phosphorylation in cancer cells , 2005, Nature Biotechnology.

[63]  T. Takenawa,et al.  Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts. , 2002, Cancer research.

[64]  N. Worth,et al.  Vascular smooth muscle cell phenotypic modulation in culture is associated with reorganisation of contractile and cytoskeletal proteins. , 2001, Cell motility and the cytoskeleton.

[65]  M. De Brabander,et al.  Ultrastructural localization of alpha-actinin and filamin in cultured cells with the immunogold staining (IGS) method , 1984, The Journal of cell biology.

[66]  K. Fujiwara,et al.  Distribution of alpha-actinin in single isolated smooth muscle cells , 1983, The Journal of cell biology.

[67]  J. Condeelis,et al.  High-resolution live-cell imaging and time-lapse microscopy of invadopodium dynamics and tracking analysis. , 2013, Methods in molecular biology.

[68]  J. Segall,et al.  Molecular mechanisms of invadopodium formation: the role of the N-WASP–Arp2/3 complex pathway and cofilin , 2005 .