1 Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China 2 Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 3 Toxicology Centre University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 4 School of Environment and Sustainability, University of Saskatchewan, Saskatoon, Saskatchewan, Canada. 5 Department of Zoology, and Center for Integrative Toxicology, Michigan State University, East Lansing, MI, USA 6 Department of Biology & Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, SAR, China * E-mail: tangjch@nankai.edu.cn