Arteriographic evaluation of small coronary arteries.

The purpose of this study was to determine the accuracy of imaging small coronary arteries with current radiographic equipment. Phantom assessments were performed using a phantom that comprises a large array of circular objects of varying diameter and contrast density. More objects could be identified in the moving cinearteriogram than in single cine frames. Using the largest object as the calibration standard, diameters less than 1 mm were markedly overestimated. A simple morphometric method showed that arteriographic visualization of small vessels was better by digital processing than by cine recording. However, there was no statistically significant difference in the average size of the smallest identifiable vessel by either method (0.5 versus 0.51 mm). After correcting for overestimation and the inaccurate imaging of the smallest detectable vessels, the practical arteriographic threshold is approximately 0.5 mm. Parametric imaging holds promise, but its significance for evaluating small vessel disease has yet to be determined.

[1]  A. Bruschke,et al.  Clinical Course of Patients with Normal or Slightly or Moderately Abnormal Coronary Arteriograms: 10‐year Follow‐up of 521 Patients , 1980, Circulation.

[2]  R. Cannon,et al.  Angina caused by reduced vasodilator reserve of the small coronary arteries. , 1983, Journal of the American College of Cardiology.

[3]  R. Vogel The radiographic assessment of coronary blood flow parameters. , 1985, Circulation.

[4]  J. Reiber,et al.  Does the quantitative assessment of coronary artery dimensions predict the physiologic significance of a coronary stenosis? , 1987, Circulation.

[5]  J. Dankelman,et al.  Local Control of Coronary Flow , 1987 .

[6]  W Grossman,et al.  Optimal resources for examination of the heart and lungs: cardiac catheterization and radiographic facilities. Examination of the Chest and Cardiovascular System Study Group. , 1983, Circulation.

[7]  J. Elion,et al.  Methods for Calculation of Coronary Flow Reserve by Computer Processing of Digital Angiograms , 1988 .

[8]  Sones Fm,et al.  Cine-coronary arteriography. , 1962 .

[9]  B. Amor,et al.  Reduced coronary flow and resistance reserve in primary scleroderma myocardial disease. , 1986, American heart journal.

[10]  J. Hoffman Maximal coronary flow and the concept of coronary vascular reserve. , 1984, Circulation.

[11]  R. Bonow,et al.  Myocardial ischemia in patients with hypertrophic cardiomyopathy: contribution of inadequate vasodilator reserve and elevated left ventricular filling pressures. , 1985, Circulation.

[12]  J. Hodgson,et al.  Assessment of coronary flow reserve using digital angiography before and after successful percutaneous transluminal coronary angioplasty. , 1987, The American journal of cardiology.

[13]  F. Harrell,et al.  Prognostic implications of angiographically normal and insignificantly narrowed coronary arteries. , 1986, The American journal of cardiology.

[14]  A. Nitenberg,et al.  Multifactorial determinants of reduced coronary flow reserve after dipyridamole in dilated cardiomyopathy. , 1985, The American journal of cardiology.

[15]  A. Osterspey,et al.  [Value of the dipyridamole test in the diagnosis of coronary heart disease. Comparison with the stress ECG and coronary angiogram]. , 2008, Deutsche Medizinische Wochenschrift.

[16]  C A Mistretta,et al.  Digital subtraction angiographic imaging of coronary flow reserve. , 1987, Circulation.

[17]  R. Cannon,et al.  Site of increased resistance to coronary flow in patients with angina pectoris and normal epicardial coronary arteries. , 1986, Journal of the American College of Cardiology.

[18]  E. Bates,et al.  Abnormal coronary flow reserve and abnormal radionuclide exercise test results in patients with normal coronary angiograms. , 1985, Journal of the American College of Cardiology.

[19]  B. Livesley,et al.  Angina pectoris with normal coronary arteries. Transvenous myocardial biopsy in diagnosis. , 1974, Lancet.

[20]  H. Toshima,et al.  Impaired coronary vasodilatory capacity after dipyridamole administration in hypertrophic cardiomyopathy. , 1987, Japanese heart journal.

[21]  G.B.John Mancini,et al.  Comparison of 35 mm Cine Film and Digital Radiographic Image Imaging for Quantitative Coronary Arteriography , 1988 .

[22]  K. Gould,et al.  Assessing stenosis severity: coronary flow reserve, collateral function, quantitative coronary arteriography, positron imaging, and digital subtraction angiography. A review and analysis. , 1988, Progress in cardiovascular diseases.

[23]  J. Forrester,et al.  Digital angiographic measurement of radiographic contrast material kinetics for estimation of myocardial perfusion. , 1986, Circulation.