SECTION 1 – The Uptake and Transport of Lysosomal Enzymes

[1]  D. Neville,et al.  Mannose 6-phosphate receptor-mediated uptake of modified low density lipoprotein results in down regulation of hydroxymethylglutaryl-CoA reductase in normal and familial hypercholesterolemic fibroblasts. , 1980, The Journal of biological chemistry.

[2]  H. Freeze,et al.  Acid hydrolases from Dictyostelium discoideum contain phosphomannosyl recognition markers. , 1980, The Journal of biological chemistry.

[3]  K. von Figura,et al.  Phosphorylated oligosaccharides in lysosomal enzymes: identification of alpha-N-acetylglucosamine(1)phospho(6)mannose diester groups. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[4]  A. Varki,et al.  Structural studies of phosphorylated high mannose-type oligosaccharides. , 1980, The Journal of biological chemistry.

[5]  D. Morré,et al.  Phosphomannosyl-enzyme receptors in rat liver. Subcellular distribution and role in intracellular transport of lysosomal enzymes. , 1980, The Journal of biological chemistry.

[6]  A. Varki,et al.  Identification of a rat liver alpha-N-acetylglucosaminyl phosphodiesterase capable of removing "blocking" alpha-N-acetylglucosamine residues from phosphorylated high mannose oligosaccharides of lysosomal enzymes. , 1980, The Journal of biological chemistry.

[7]  E. Karson,et al.  p-Isothiocyanatophenyl 6-phospho-alpha-D-mannopyranoside coupled to albumin. A model compound recognized by the fibroblast lysosomal enzyme uptake system. 2. Biological properties. , 1980, Biochemistry.

[8]  S. Kornfeld,et al.  Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues. , 1980, The Journal of biological chemistry.

[9]  W. Sly,et al.  Beta-glucuronidase binding to human fibroblast membrane receptors. , 1980, The Journal of biological chemistry.

[10]  J. Grubb,et al.  Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling , 1980, The Journal of cell biology.

[11]  A. Hasilik,et al.  Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight. , 1980, The Journal of biological chemistry.

[12]  A. Hasilik,et al.  Biosynthesis of lysosomal enzymes in fibroblasts. Phosphorylation of mannose residues. , 1980, The Journal of biological chemistry.

[13]  H. Freeze,et al.  Purification and characterization of I-cell disease alpha-L-fucosidase. , 1980, The Journal of biological chemistry.

[14]  A. Helenius,et al.  On the entry of semliki forest virus into BHK-21 cells , 1980, The Journal of cell biology.

[15]  M. Natowicz,et al.  Fibroblast receptor for lysosomal enzymes mediates pinocytosis of multivalent phosphomannan fragment , 1980, The Journal of cell biology.

[16]  G. Bach,et al.  I-cell disease: deficiency of extracellular hydrolase phosphorylation. , 1979, Biochemical and biophysical research communications.

[17]  G. Blobel,et al.  Early events in the biosynthesis of the lysosomal enzyme cathepsin D. , 1979, The Journal of biological chemistry.

[18]  R. Swank,et al.  Biosynthesis of two lysosomal enzymes in macrophages. Evidence for a precursor of beta-galactosidase. , 1979, The Journal of biological chemistry.

[19]  G. Sahagian,et al.  Identification of mannose 6-phosphate in glycoproteins that inhibit the assimilation of beta-galactosidase by fibroblasts. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[20]  O. H. Lowry,et al.  Enzymatic identification of mannose 6-phosphate on the recognition marker for receptor-mediated pinocytosis of beta-glucuronidase by human fibroblasts. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[21]  K. von Figura,et al.  Endocytosis of beta-N-acetylglucosaminidase from sections of mucolipidosis-II and-III fibroblasts by non-parenchymal rat liver cells. , 1979, The Biochemical journal.

[22]  K. von Figura,et al.  Cell surface-associated lysosomal enzymes in cultured human skin fibroblasts. , 1979, Experimental cell research.

[23]  G. Martin,et al.  Teratocarcinoma stem cells have a cell surface carbohydrate-binding component implicated in cell-cell adhesion , 1979, Cell.

[24]  L. Rome,et al.  Direct demonstration of binding of a lysosomal enzyme, alpha-L-iduronidase, to receptors on cultured fibroblasts. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[25]  M. Rattazzi,et al.  Excretion-reuptake route of beta-hexosaminidase in normal and I-cell disease cultured fibroblasts. , 1979, The Journal of clinical investigation.

[26]  A. R. Robbins.  Isolation of lysosomal α-mannosidase mutants of Chinese hamster ovary cells , 1979 .

[27]  C. W. Hall,et al.  Inhibition of receptor-mediated uptake of a lysosomal enzyme into fibroblasts by chloroquine, procaine and ammonia. , 1979, Experimental cell research.

[28]  K. Figura,et al.  Isolation and Characterization of Phosphorylated Oligosaccharides from α‐N‐Acetylglucosaminidase that Are Recognized by Cell‐Surface Receptors , 1979 .

[29]  A. Miller,et al.  Urinary lysosomal hydrolases in mucolipidosis II and mucolipidosis III. , 1979, The Biochemical journal.

[30]  R. Schmickel,et al.  The Role of Glycosidically-Bound Mannose in the Cellular Assimilation of β-D-Galactosidase , 1979 .

[31]  K. von Figura,et al.  An alternative hypothesis of cellular transport of lysosomal enzymes in fibroblasts. Effect of inhibitors of lysosomal enzyme endocytosis on intra- and extra-cellular lysosomal enzyme activities. , 1978, The Biochemical journal.

[32]  S. Kornfeld,et al.  The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides. , 1978, The Journal of biological chemistry.

[33]  W. Sly,et al.  Human β-glucuronidase: In vivo clearance and in vitro uptake by a glycoprotein recognition system on reticuloendothelial cells , 1978, Cell.

[34]  B Poole,et al.  Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R. Brady,et al.  The uptake of native and desialylated glucocerebrosidase by rat hepatocytes and Kupffer cells. , 1978, Biochemical and biophysical research communications.

[36]  K. von Figura,et al.  Evidence for lysosomal enzyme recognition by human fibroblasts via a phosphorylated carbohydrate moiety. , 1978, The Biochemical journal.

[37]  Mark J. Miller,et al.  Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[38]  S. Kornfeld,et al.  Processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis virus G protein and the IgG heavy chain. , 1978, The Journal of biological chemistry.

[39]  W. Sly,et al.  Correlation of structural features of phosphomannans with their ability to inhibit pinocytosis of human beta-glucuronidase by human fibroblasts. , 1978, The Journal of biological chemistry.

[40]  W. Sly,et al.  Phosphohexosyl recognition is a general characteristic of pinocytosis of lysosomal glycosidases by human fibroblasts. , 1977, The Journal of clinical investigation.

[41]  E. Neufeld,et al.  Recognition and receptor-mediated uptake of a lysosomal enzyme, α-l-iduronidase, by cultured human fibroblasts , 1977, Cell.

[42]  W. Sly,et al.  Human β-Glucuronidase. I. Recognition and Uptake by Animal Fibroblasts Suggests Animal Models for Enzyme Replacement Studies , 1977, Pediatric Research.

[43]  W. Sly,et al.  Phosphohexosyl components of a lysosomal enzyme are recognized by pinocytosis receptors on human fibroblasts. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[44]  J. Lloyd.  Cellular transport of lysosomal enzymes: an alternative hypothesis. , 1977, The Biochemical journal.

[45]  R. Schmickel,et al.  The role of glycosidically bound mannose in the assimilation of beta-galactosidase by generalized gangliosidosis fibroblasts. , 1976, Biochemical and biophysical research communications.

[46]  P. Schlesinger,et al.  Evidence for specific recognition sites mediating clearance of lysosomal enzymes in vivo. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[47]  A. Novikoff,et al.  The endoplasmic reticulum: a cytochemist's view (a review). , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[48]  M. Rattazzi,et al.  Abnormal lysosomal hydrolases excreted by cultured fibroblasts in I-cell disease (mucolipidosis II). , 1975, Biochemical and biophysical research communications.

[49]  S. Didonato,et al.  Effect of chloroquine on cultured fibroblasts: release of lysosomal hydrolases and inhibition of their uptake. , 1975, Biochemical and biophysical research communications.

[50]  W. Sly,et al.  Multiple isoelectric and recognition forms of human β-glucuronidase activity , 1975 .

[51]  D. Nicol,et al.  Differential uptake of human beta-glucuronidase isoenzymes from spleen by deficient fibroblasts. , 1974, Biochemical and biophysical research communications.

[52]  E. Neufeld,et al.  A recognition marker required for uptake of a lysosomal enzyme by cultured fibroblasts. , 1974, Biochemical and biophysical research communications.

[53]  W. Sly,et al.  In vitro correction of deficient human fibroblasts by beta-glucuronidase from different human sources. , 1974, Biochemical and biophysical research communications.

[54]  E. Neufeld,et al.  A hypothesis for I-cell disease: defective hydrolases that do not enter lysosomes. , 1972, Biochemical and biophysical research communications.

[55]  E. Neufeld,et al.  CORRECTIVE FACTORS FOR INBORN ERRORS OF MUCOPOLYSACCHARIDE METABOLISM , 1971, Annals of the New York Academy of Sciences.

[56]  C. W. Hall,et al.  Hurler and Hunter Syndromes: Mutual Correction of the Defect in Cultured Fibroblasts , 1968, Science.

[57]  D. Friend,et al.  FUNCTIONS OF COATED VESICLES DURING PROTEIN ABSORPTION IN THE RAT VAS DEFERENS , 1967, The Journal of cell biology.

[58]  A. Garvin,et al.  The transport of lysosomal enzymes. , 1977, Journal of supramolecular structure.

[59]  E. Neufeld,et al.  Inherited disorders of lysosomal metabolism. , 1975, Annual review of biochemistry.

[60]  K. von Figura,et al.  Quantitative aspects of pinocytosis and the intracellular fate of N-acetyl-alpha-D-glucosaminidase in Sanfilippo B fibroblasts. , 1974, The Journal of clinical investigation.

[61]  C. Duve,et al.  Functions of lysosomes. , 1966, Annual review of physiology.