Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil.

Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection in endemic areas might facilitate more effective schistosomiasis control. We conducted a cross-sectional study of persons resistant to schistosomiasis and found no association between socioeconomic status and resistance to infection. Mononuclear cells of resistant subjects produced higher levels of interleukin-5 (IL-5), IL-13 and interferon-γ upon stimulation with soluble egg antigen (SEA) compared with infected persons. When stimulated with Sm21.6 or Sm22.6, levels of IL-10 were higher in cell culture of resistant persons. Levels of IgE against soluble adult worm antigen (SWAP) and against interleukin-4-inducing principle from S. mansoni eggs (IPSE) and levels of IgG4 against SWAP, SEA, and Sm22.6 were lower in the resistant group compared with the susceptible group. Our data suggest that socioeconomic status could not fully explain resistance to S. mansoni infection observed in the studied area. However, a mixture of Th1 and Th2 immune responses and low levels of specific IgG4 against parasite antigens could be mediating resistance to infection.

[1]  M. Caliari,et al.  IPSE/alpha‐1 of Schistosoma mansoni egg induces enlargement of granuloma but does not alter Th2 balance after infection , 2010, Parasite immunology.

[2]  R. Corrêa-Oliveira,et al.  Schistosoma mansoni infection in a rural area of the Jequitinhonha Valley, Minas Gerais, Brazil: analysis of exposure risk. , 2010, Acta tropica.

[3]  R. Corrêa-Oliveira,et al.  Sm21.6 a novel EF-hand family protein member located on the surface of Schistosoma mansoni adult worm that failed to induce protection against challenge infection but reduced liver pathology. , 2009, Vaccine.

[4]  S. Meshnick,et al.  Prevalence Distribution and Risk Factors for Schistosoma hematobium Infection among School Children in Blantyre, Malawi , 2009, PLoS neglected tropical diseases.

[5]  T. Beaty,et al.  High heritability but uncertain mode of inheritance for total serum IgE level and Schistosoma mansoni infection intensity in a schistosomiasis-endemic Brazilian population. , 2008, The Journal of infectious diseases.

[6]  S. Verjovski-Almeida,et al.  Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection , 2008, PLoS neglected tropical diseases.

[7]  J. Utzinger,et al.  Trick or Treat: The Role of Vaccines in Integrated Schistosomiasis Control , 2008, PLoS neglected tropical diseases.

[8]  Alex Loukas,et al.  Current Status of Vaccines for Schistosomiasis , 2008, Clinical Microbiology Reviews.

[9]  M. Barreto,et al.  The relative influence of polyparasitism, environment, and host factors on schistosome infection. , 2007, The American journal of tropical medicine and hygiene.

[10]  M. Tanner,et al.  Risk factors for Schistosoma mansoni and hookworm in urban farming communities in western Côte d'Ivoire , 2007, Tropical medicine & international health : TM & IH.

[11]  E. Pearce,et al.  Cutting Edge: IPSE/alpha-1, a Glycoprotein from Schistosoma mansoni Eggs, Induces IgE-Dependent, Antigen-Independent IL-4 Production by Murine Basophils In Vivo1 , 2007, The Journal of Immunology.

[12]  R. Oliveira,et al.  Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis , 2007, Microbial cell factories.

[13]  G. Velásquez-Melendez,et al.  Socioeconomic determinants of schistosomiasis in a poor rural area in Brazil. , 2006, Acta tropica.

[14]  A. Swindale,et al.  Development of a universally applicable household food insecurity measurement tool: process, current status, and outstanding issues. , 2006, The Journal of nutrition.

[15]  S. Oliveira,et al.  Immunization with Schistosoma mansoni 22.6 kDa antigen induces partial protection against experimental infection in a recombinant protein form but not as DNA vaccine. , 2006, Immunobiology.

[16]  A. Miyoshi,et al.  Oral administration of a live Aro attenuated Salmonella vaccine strain expressing 14-kDa Schistosoma mansoni fatty acid-binding protein induced partial protection against experimental schistosomiasis. , 2005, Acta tropica.

[17]  Á. Cruz,et al.  Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma. , 2004, The Journal of infectious diseases.

[18]  Peter G. Smith,et al.  Socioeconomic determinants of schistosomiasis in an urban area in the Northeast of Brazil. , 2003, Revista panamericana de salud publica = Pan American journal of public health.

[19]  R. Quinnell.  Genetics of susceptibility to human helminth infection. , 2003, International journal for parasitology.

[20]  Franco H Falcone,et al.  Molecular Characterization of an Interleukin-4-inducing Factor from Schistosoma mansoni Eggs* , 2003, The Journal of Biological Chemistry.

[21]  D. Karanja,et al.  Resistance to reinfection with Schistosoma mansoni in occupationally exposed adults and effect of HIV-1 co-infection on susceptibility to schistosomiasis: a longitudinal study , 2002, The Lancet.

[22]  M. Burattini,et al.  Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni. , 2002, The Journal of infectious diseases.

[23]  Prevention and control of schistosomiasis and soil-transmitted helminthiasis , 2004 .

[24]  R. Sturrock.  Schistosomiasis epidemiology and control: how did we get here and where should we go? , 2001, Memorias do Instituto Oswaldo Cruz.

[25]  R. Corrêa-Oliveira,et al.  Exposure to Schistosoma mansoni infection in a rural area of Brazil. I: Water contact , 2001, Tropical medicine & international health : TM & IH.

[26]  Brito,et al.  CD4+ T Cells of Schistosomiasis Naturally Resistant Individuals Living in an Endemic Area Produce Interferon‐γ and Tumour Necrosis Factor‐α in Response to The Recombinant 14kdaSchistosoma mansoni Fatty Acid‐Binding Protein , 2000, Scandinavian journal of immunology.

[27]  A. Hoerauf,et al.  Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by Th3/Tr1-type cytokines IL-10 and transforming growth factor-β but not by a Th1 to Th2 shift , 2000 .

[28]  E. Pearce,et al.  Human Immune Responses to Schistosoma mansoni Vaccine Candidate Antigens , 2000, Infection and Immunity.

[29]  R. Corrêa-Oliveira,et al.  Susceptibility and resistance to Schistosoma mansoni reinfection: parallel cellular and isotypic immunologic assessment. , 2000, The American journal of tropical medicine and hygiene.

[30]  A. Hoerauf,et al.  Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift. , 2000, International immunology.

[31]  M. Woolhouse,et al.  Seeking the ghost of worms past , 1999, Nature Medicine.

[32]  M. I. Araújo,et al.  Detection of specific IgE antibodies in parasite diseases. , 1999, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[33]  A. Deelder,et al.  Development of Antibody Isotype Responses to Schistosoma mansoni in an Immunologically Naive Immigrant Population: Influence of Infection Duration, Infection Intensity, and Host Age , 1999, Infection and Immunity.

[34]  J. B. Alves,et al.  Induction of protective immunity and modulation of granulomatous hypersensitivity in mice using PIII, an anionic fraction of Schistosoma mansoni adult worm , 1997, Parasitology.

[35]  F. Finkelman,et al.  Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models. , 1997, Annual review of immunology.

[36]  B. Mordmüller,et al.  Antischistosome IgG4 and IgE responses are affected differentially by chemotherapy in children versus adults. , 1996, The Journal of infectious diseases.

[37]  R. Garratt,et al.  A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[38]  R. Corrêa-Oliveira,et al.  Comparison of antibody isotype responses to Schistosoma mansoni antigens by infected and putative resistant individuals living in an endemic area , 1995, Parasite immunology.

[39]  R. Sturrock,et al.  A statistical approach to schistosome population dynamics and estimation of the life-span of Schistosoma mansoni in man , 1995, Parasitology.

[40]  A. Sher,et al.  Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens. , 1994, The Journal of infectious diseases.

[41]  A. Sher,et al.  Interferon-gamma production by peripheral blood mononuclear cells from residents of an area endemic for Schistosoma mansoni. , 1994, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[42]  D. Dunne,et al.  Immunity after treatment of human schistosomiasis: association between cellular responses and resistance to reinfection , 1993, Infection and immunity.

[43]  M. Ouattara,et al.  Resistance to Schistosoma mansoni in humans: influence of the IgE/IgG4 balance and IgG2 in immunity to reinfection after chemotherapy. , 1993, The Journal of infectious diseases.

[44]  A. Capron,et al.  Immunity after treatment of human schistosomiasis: association between IgE antibodies to adult worm antigens and resistance to reinfection , 1992, European journal of immunology.

[45]  D. Colley,et al.  Human immune responses during schistosomiasis mansoni. , 1992, Revista da Sociedade Brasileira de Medicina Tropical.

[46]  R. Corrêa-Oliveira,et al.  Differential cellular reactivity to adult worm antigens of patients with different clinical forms of schistosomiasis mansoni. , 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[47]  A. Prata,et al.  Evidence for an association between human resistance to Schistosoma mansoni and high anti‐larval IgE levels , 1991, European journal of immunology.

[48]  L. Abel,et al.  Evidence for the segregation of a major gene in human susceptibility/resistance to infection by Schistosoma mansoni. , 1991, American journal of human genetics.

[49]  D. Colley,et al.  A multivariate analysis of socio-demographic factors, water contact patterns and Schistosoma mansoni infection in an endemic area in Brazil. , 1991, Revista do Instituto de Medicina Tropical de Sao Paulo.

[50]  A. Simpson,et al.  Human IgE, IgG4 and resistance to reinfection with Schistosomahaematobium , 1991, Nature.

[51]  A. Sher,et al.  The human immune response to defined immunogens of Schistosoma mansoni: elevated antibody levels to paramyosin in stool-negative individuals from two endemic areas in Brazil. , 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[52]  R. Hayes,et al.  Resistance to reinfection after treatment of urinary schistosomiasis. , 1987, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[53]  C. Antunes,et al.  Water-contact patterns and socioeconomic variables in the epidemiology of schistosomiasis mansoni in an endemic area in Brazil. , 1987, Bulletin of the World Health Organization.

[54]  M. King.  At risk drinking among general practice attenders: validation of the CAGE questionnaire , 1986, Psychological Medicine.

[55]  A. Barbour,et al.  The importance of age and water contact patterns in relation to Schistosoma haematobium infection. , 1985, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[56]  J. Ewing,et al.  Detecting alcoholism. The CAGE questionnaire. , 1984, JAMA.

[57]  E Guillibert,et al.  [Detecting alcoholism]. , 1984, Soins; la revue de reference infirmiere.

[58]  P. Das,et al.  IgG4 antibodies in Egyptian patients with schistosomiasis. , 1981, International archives of allergy and applied immunology.

[59]  D. Mayfield,et al.  The CAGE questionnaire: validation of a new alcoholism screening instrument. , 1974, The American journal of psychiatry.

[60]  P. Coelho,et al.  Evaluation of Kato's quantitative method through the recovery of Schistosoma mansoni eggs added to human feces. , 1970, The Journal of parasitology.