Role of Type I Interferon Signaling and Microglia in the Abnormal Long-term Potentiation and Object Place Recognition Deficits of Male Mice With a Mutation of the Tuberous Sclerosis 2 Gene

[1]  Alcino J. Silva,et al.  Postnatal immune activation causes social deficits in a mouse model of tuberous sclerosis: Role of microglia and clinical implications , 2021, Science advances.

[2]  J. Lacaille,et al.  Tsc1 haploinsufficiency in Nkx2.1 cells upregulates hippocampal interneuron mTORC1 activity, impairs pyramidal cell synaptic inhibition, and alters contextual fear discrimination and spatial working memory in mice , 2020, Molecular Autism.

[3]  M. Wong.  The role of glia in epilepsy, intellectual disability, and other neurodevelopmental disorders in tuberous sclerosis complex , 2019, Journal of Neurodevelopmental Disorders.

[4]  Pengcheng Zhou,et al.  CA1-Projecting Subiculum Neurons Facilitate Object-Place Learning , 2019, Nature Neuroscience.

[5]  R. Feil,et al.  Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging , 2017, Nature Neuroscience.

[6]  J. Weinstein,et al.  Microglial Interferon Signaling and White Matter , 2017, Neurochemical Research.

[7]  Luis de la Torre Ubieta,et al.  Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism , 2016, Nature.

[8]  B. Zhang,et al.  Microglial activation during epileptogenesis in a mouse model of tuberous sclerosis complex , 2016, Epilepsia.

[9]  A. Vignoli,et al.  Autism spectrum disorder in tuberous sclerosis complex: searching for risk markers , 2015, Orphanet Journal of Rare Diseases.

[10]  A. Najafi,et al.  Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice , 2015, Journal of Neuroinflammation.

[11]  M. Sahin,et al.  Tuberous Sclerosis: A New Frontier in Targeted Treatment of Autism , 2015, Neurotherapeutics.

[12]  Annie Vogel-Ciernia,et al.  Examining Object Location and Object Recognition Memory in Mice , 2014, Current protocols in neuroscience.

[13]  Brian L. West,et al.  Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain , 2014, Neuron.

[14]  J. Yates,et al.  Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor , 2013, Cell.

[15]  M. Johnston,et al.  Potential for treatment of severe autism in tuberous sclerosis complex. , 2013, World journal of clinical pediatrics.

[16]  A. Mildner,et al.  Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. , 2013, Immunity.

[17]  E. Aronica,et al.  Fetal Brain Lesions in Tuberous Sclerosis Complex: TORC1 Activation and Inflammation , 2013, Brain pathology.

[18]  W. Regehr,et al.  Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice , 2012, Nature.

[19]  M. Mizuguchi,et al.  Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex , 2012, Nature Communications.

[20]  Mark F. Bear,et al.  Mutations causing syndromic autism define an axis of synaptic pathophysiology , 2011, Nature.

[21]  G. Barker,et al.  When Is the Hippocampus Involved in Recognition Memory? , 2011, The Journal of Neuroscience.

[22]  Marcelo A Wood,et al.  Hippocampal Focal Knockout of CBP Affects Specific Histone Modifications, Long-Term Potentiation, and Long-Term Memory , 2011, Neuropsychopharmacology.

[23]  Alcino J. Silva,et al.  Increased Levels of Anxiety-related Behaviors in a Tsc2 Dominant Negative Transgenic Mouse Model of Tuberous Sclerosis , 2011, Behavior genetics.

[24]  M. Wood,et al.  HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner. , 2011, Learning & memory.

[25]  P. D. Vries,et al.  Targeted treatments for cognitive and neurodevelopmental disorders in tuberous sclerosis complex , 2010, Neurotherapeutics.

[26]  S. Camposano,et al.  The natural history of epilepsy in tuberous sclerosis complex , 2009, Epilepsia.

[27]  Alcino J. Silva,et al.  From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis. , 2009, Journal of intellectual disability research : JIDR.

[28]  B. Manning,et al.  A complex interplay between Akt, TSC2 and the two mTOR complexes. , 2009, Biochemical Society transactions.

[29]  E. Aronica,et al.  Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex , 2008, Neuropathology : official journal of the Japanese Society of Neuropathology.

[30]  Alcino J. Silva,et al.  Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis , 2008, Nature Medicine.

[31]  B. Manning,et al.  The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2 , 2008, Molecular and Cellular Biology.

[32]  E. Aronica,et al.  Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex , 2008, Epilepsy Research.

[33]  C. Ribak,et al.  Rapid astrocyte and microglial activation following pilocarpine‐induced seizures in rats , 2008, Epilepsia.

[34]  J. Cheadle,et al.  Cognitive deficits in Tsc1+/−mice in the absence of cerebral lesions and seizures , 2007, Annals of neurology.

[35]  D. Holtzman,et al.  Abnormal glutamate homeostasis and impaired synaptic plasticity and learning in a mouse model of tuberous sclerosis complex , 2007, Neurobiology of Disease.

[36]  E T Bullmore,et al.  Neuroanatomical correlates of memory deficits in tuberous sclerosis complex. , 2007, Cerebral cortex.

[37]  I. Izquierdo,et al.  mTOR signaling in the hippocampus is necessary for memory formation , 2007, Neurobiology of Learning and Memory.

[38]  G. Baird,et al.  Medical investigation of children with autistic spectrum disorders. , 2006, Child: care, health and development.

[39]  M. López-Aranda,et al.  Localization of the GoLoco motif carrier regulator of G‐protein signalling 12 and 14 proteins in monkey and rat brain , 2006, The European journal of neuroscience.

[40]  H. Beck,et al.  Impaired synaptic plasticity in a rat model of tuberous sclerosis , 2006, The European journal of neuroscience.

[41]  D. Kwiatkowski,et al.  Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. , 2005, Human molecular genetics.

[42]  D. Mumby,et al.  Hippocampal damage and exploratory preferences in rats: memory for objects, places, and contexts. , 2002, Learning & memory.

[43]  H. Onda,et al.  Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. , 1999, The Journal of clinical investigation.

[44]  S Povey,et al.  Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. , 1997, Science.

[45]  S. Thomas,et al.  Identification and characterization of the tuberous sclerosis gene on chromosome 16 , 1993, Cell.

[46]  A. Ennaceur,et al.  A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory , 1992, Behavioural Brain Research.

[47]  S. Smalley,et al.  Autism and tuberous sclerosis , 1992, Journal of autism and developmental disorders.

[48]  J. Delacour,et al.  A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data , 1988, Behavioural Brain Research.

[49]  A. Maekawa,et al.  An autopsy case of tuberous sclerosis. , 1970, Nagoya medical journal.

[50]  B. King,et al.  Tuberous sclerosis associated neuropsychiatric disorders (TAND) and the TAND Checklist. , 2015, Pediatric neurology.

[51]  K. Inoki,et al.  TSC2: filling the GAP in the mTOR signaling pathway. , 2004, Trends in biochemical sciences.