The formalin test: an evaluation of the method

[1]  C. Porro,et al.  Functional activity mapping of the rat brainstem during formalin-induced noxious stimulation , 1991, Neuroscience.

[2]  C. A. Porro,et al.  Functional activity mapping of the rat spinal cord during formalin-induced noxious stimulation , 1991, Neuroscience.

[3]  K. McCarson,et al.  Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat , 1991, Brain Research.

[4]  O. Berge,et al.  Hyperbaric exposure and morphine alter the pattern of behavior in the formalin test , 1991, Pharmacology Biochemistry and Behavior.

[5]  K. Franklin,et al.  Dopamine receptor subtypes and formalin test analgesia , 1991, Pharmacology Biochemistry and Behavior.

[6]  K. Hole,et al.  Lesions of bulbo-spinal serotonergic or noradrenergic pathways reduce nociception as measured by the formalin test. , 1991, Acta physiologica Scandinavica.

[7]  J. Rosland.  The formalin test in mice: the influence of ambient temperature , 1991, Pain.

[8]  K. Hole,et al.  Chronic administration of desipramine and zimelidine changes the behavioural response in the formalin test in rats , 1991, Neuropharmacology.

[9]  A. Woda,et al.  Responses of trigeminal subnucleus oralis nociceptive neurones to subcutaneous formalin in the rat , 1991, Neuroscience Letters.

[10]  A. Cowan,et al.  Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists. , 1991, The Journal of pharmacology and experimental therapeutics.

[11]  K. Hole,et al.  Antinociceptive effect of paracetamol in rats is partly dependent on spinal serotonergic systems. , 1991, European journal of pharmacology.

[12]  R. A. Hughes,et al.  Morphine hyperalgesic effects on the formalin test in domestic fowl (Gallus gallus) , 1991, Pharmacology Biochemistry and Behavior.

[13]  J. Haley,et al.  Peripheral κ-opioid modulation of the formalin response: an electrophysiological study in the rat , 1990 .

[14]  R. Melzack,et al.  Central nervous system plasticity in the tonic pain response to subcutaneous formalin injection , 1990, Brain Research.

[15]  S. Candeletti,et al.  Antinociceptive profile of intracerebroventricular salmon calcitonin and calcitonin gene-related peptide in the mouse formalin test , 1990, Neuropeptides.

[16]  K. Hole,et al.  The formalin test in mice: effect of formalin concentration , 1990, Pain.

[17]  M. Fanselow,et al.  Tonic nociception in neonatal rats , 1990, Pharmacology Biochemistry and Behavior.

[18]  K. Hole,et al.  Nociception in Crocodiles: Capsaicin Instillation, Formalin and Hot Plate Tests: COMMUNICATION: Physiology , 1990 .

[19]  K. Franklin,et al.  6-Hydroxydopamine lesions of the ventral tegmentum abolishd-amphetamine and morphine analgesia in the formalin test but not in the tail flick test , 1990, Brain Research.

[20]  M. Hamon,et al.  Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord , 1990, Pain.

[21]  S. Hunskaar,et al.  Diazepam attenuates morphine antinociception test-dependently in mice. , 1990, Pharmacology & toxicology.

[22]  R. J. Milne,et al.  Hypercapnia depresses nociception: endogenous opioids implicated , 1990, Brain Research.

[23]  A. Pertovaara,et al.  The effect of medetomidine, an α2-adrenoceptor agonist, in various pain tests , 1990 .

[24]  K. McCarson,et al.  Time course of the alteration in dorsal horn substance p levels following formalin: blockade by naloxone , 1990, Pain.

[25]  H. Yoshino,et al.  Analgesia produced by E-2078, a systemically active dynorphin analog, in mice. , 1990, The Journal of pharmacology and experimental therapeutics.

[26]  R. Inoki,et al.  Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord. , 1990, The Journal of pharmacology and experimental therapeutics.

[27]  S. Hunt,et al.  Spinal c-fos induction by sensory stimulation in neonatal rats , 1990, Neuroscience Letters.

[28]  F. Porreca,et al.  The rat paw formalin test: comparison of noxious agents , 1990, Pain.

[29]  J. A. Tarapacki,et al.  Amniotic fluid ingestion enhances opioid-mediated but not nonopioid-mediated analgesia , 1990, Physiology & Behavior.

[30]  A. Cowan,et al.  Formalin nociception in the mouse does not lead to increased spinal serotonin turnover , 1990, Neuroscience Letters.

[31]  A I Basbaum,et al.  Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[32]  A. Pertovaara,et al.  Effect of subcutaneous formalin treatment on responses to bulboreticular nociceptive neurons in the rat , 1989, Brain Research Bulletin.

[33]  S. Hunskaar,et al.  Antinociceptive effects of serotonergic reuptake inhibitors in mice , 1989, Neuropharmacology.

[34]  Ronald Melzack,et al.  Analgesia produced by injection of lidocaine into the anterior cingulum bundle of the rat , 1989, Pain.

[35]  B. Roques,et al.  δ‐Opioid mediated inhibitions of acute and prolonged noxious‐evoked responses in rat dorsal horn neurones , 1989, British journal of pharmacology.

[36]  J. Giordano,et al.  Peripherally administered serotonin 5-HT3 receptor antagonists reduce inflammatory pain in rats. , 1989, European journal of pharmacology.

[37]  J. Giordano,et al.  Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats , 1989, Pain.

[38]  P. Raboisson,et al.  Application of the formalin test to the study of orofacial pain in the rat , 1989, Neuroscience Letters.

[39]  M. Fanselow,et al.  Role of mu and kappa opioid receptors in conditional fear-induced analgesia: the antagonistic actions of nor-binaltorphimine and the cyclic somatostatin octapeptide, Cys2Tyr3Orn5Pen7-amide. , 1989, The Journal of pharmacology and experimental therapeutics.

[40]  R. Inoki,et al.  Modified formalin test: characteristic biphasic pain response , 1989, Pain.

[41]  K. McCarson,et al.  Naloxone blocks the formalin-induced increase of substance P in the dorsal horn , 1989, Pain.

[42]  F. Porreca,et al.  Peptide fragments derived from the β-chain of hemoglobin (hemorphins) are centrally active in vivo , 1989, Peptides.

[43]  M. Fanselow,et al.  Modulation of appetitively and aversively motivated behavior by the kappa opioid antagonist MR2266. , 1989, Behavioral neuroscience.

[44]  M. Tohyama,et al.  Preproenkephalin gene expression in the rat spinal cord after noxious stimuli. , 1989, Brain Research. Molecular Brain Research.

[45]  W. Bowen,et al.  [D-Ala2,Leu5,Cys6]enkephalin: Short-term agonist effects and long-term antagonism at delta opioid receptors , 1989, Peptides.

[46]  J. Haley,et al.  Electrophysiological evidence for a role of bradykinin in chemical nociception in the rat , 1989, Neuroscience Letters.

[47]  J. Mastrianni,et al.  Activation of central μ-opioid receptors is involved in clonidine analgesia in rats , 1989, Brain Research.

[48]  T. Morrow,et al.  Cocaine: evidence for supraspinal, dopamine-mediated, non-opiate analgesia , 1989, Brain Research.

[49]  M. Fanselow,et al.  Delta opioid antagonist, 16-Me cyprenorphine, selectively attenuates conditional fear- and DPDPE-induced analgesia on the formalin test , 1989, Pharmacology Biochemistry and Behavior.

[50]  S. Hunskaar,et al.  Mechanisms of orphenadrine-induced antinociception in mice: a role for serotonergic pathways. , 1989, European journal of pharmacology.

[51]  R. Melzack,et al.  Analgesia produced by normal doses of opioid antagonists alone and in combination with morphine , 1989, Pain.

[52]  F. Porreca,et al.  Use of the formalin test in evaluating analgesics. , 1989, NIDA research monograph.

[53]  T. Pelissier,et al.  Further studies on the understanding of Octodon degus natural resistance to morphine: a comparative study with the Wistar rat. , 1989, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

[54]  T. Pelissier,et al.  New differences between the Wistar rat and Octodon degus, a putative laboratory animal resistant to morphine. , 1989, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

[55]  T. Ohkubo,et al.  [Local analgesic action and tissue irritability of nishika thesirol, a root canal disinfectant]. , 1989, Fukuoka Shika Daigaku Gakkai zasshi.

[56]  T. Pelissier,et al.  Analgesic action of clonixin, nifedipine and morphine using the formalin test. , 1989, General pharmacology.

[57]  R. Melzack,et al.  Different alpha-receptor subtypes are involved in clonidine-produced analgesia in different pain tests. , 1989, Life sciences.

[58]  L. Kocher.  Systemic naloxone does not affect pain-related behaviour in the formalin test in rat , 1988, Physiology & Behavior.

[59]  S. Young,et al.  Effect of 5-hydroxytryptamine precursors on morphine analgesia in the formalin test , 1988, Pharmacology Biochemistry and Behavior.

[60]  G. Carli,et al.  Tonic pain and social behavior in male rabbits , 1988, Behavioural Brain Research.

[61]  M. Hamba.  Effects of lesion and stimulation of rat hypothalamic arcuate nucleus on the pain system , 1988, Brain Research Bulletin.

[62]  L. Watkins,et al.  Antinociception vs motor effects of intrathecal vasopressin as measured by four pain tests , 1988, Brain Research.

[63]  H. Ueda,et al.  Endogenous GABA released into the fourth ventricle of the rat brain in vivo is enhanced by noxious stimuli , 1988, Neuroscience Letters.

[64]  J. Besson,et al.  Increased reactivity to chemical but not to heat noxious stimuli in mice producing anti-idiotypic antibodies for substance P , 1988, Brain Research.

[65]  F. Porreca,et al.  Methodological refinements to the mouse paw formalin test. An animal model of tonic pain. , 1988, Journal of pharmacological methods.

[66]  J. Svoboda,et al.  Increase in extracellular potassium level in rat spinal dorsal horn induced by noxious stimulation and peripheral injury , 1988, Brain Research.

[67]  M. Fanselow,et al.  Analgesia produced by centrally administered DAGO, DPDPE and U50488H in the formalin test. , 1988, European journal of pharmacology.

[68]  M. Tohyama,et al.  A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry. , 1988, Brain research.

[69]  F. V. Abbott.  Peripheral and central antinociceptive actions of ethylketocyclazocine in the formalin test. , 1988, European journal of pharmacology.

[70]  A. Beitz,et al.  Extracellular Amino Acid Concentrations in the Dorsal Spinal Cord of Freely Moving Rats Following Veratridine and Nociceptive Stimulation , 1988, Journal of neurochemistry.

[71]  S. Hunskaar,et al.  Modification of the antinociceptive effect of morphine by acute and chronic administration of clomipramine in mice , 1988, Pain.

[72]  E.Jørum.  The analgesic effect of peripheral nerve stimulation in various tests of nociception in rats. , 1988 .

[73]  M. Fanselow,et al.  Conditional analgesia, defensive freezing, and benzodiazepines. , 1988, Behavioral neuroscience.

[74]  R. Soto-Moyano,et al.  Topical application of morphine to the rat somatosensory corte produces analgesia to tonic pain , 1988, Journal of neuroscience research.

[75]  K. Franklin,et al.  Stimulation-produced analgesia (SPA) from brain-stem and diencephalic sites in the rat: Relationships between analgesia, aversion, seizures and catalepsy , 1988, Pain.

[76]  C. Porro,et al.  Tonic pain time-dependently affects β-endorphin-like immunoreactivity in the ventral periaqueductal gray matter of the rat brain , 1988, Neuroscience Letters.

[77]  R. Melzack,et al.  Systemic administration of naloxone produces analgesia in BALB/c mice in the formalin pain test , 1988, Neuroscience Letters.

[78]  R. Palmour,et al.  Morphine-6-glucuronide: analgesic effects and receptor binding profile in rats. , 1988, Life sciences.

[79]  S Wold,et al.  Multivariate data analysis and experimental design in biomedical research. , 1988, Progress in medicinal chemistry.

[80]  M. Fanselow,et al.  Effects of naltrexone on learning and performance of conditional fear-induced freezing and opioid analgesia , 1987, Physiology & Behavior.

[81]  A. Dickenson,et al.  Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurones , 1987, Neuroscience Letters.

[82]  R. Melzack,et al.  Analgesia produced by injection of lidocaine into the lateral hypothalamus , 1987, Pain.

[83]  S. Sakurada,et al.  [The effect of nonanoyl vanillylamide on the chemically-induced nociception]. , 1987, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[84]  M. Fanselow,et al.  Strain differences in reversal of conditional analgesia by opioid antagonists. , 1987, Behavioral neuroscience.

[85]  A. Dickenson,et al.  Subcutaneous formalin-induced activity of dorsal horn neurones in the rat: differential response to an intrathecal opiate administered pre or post formalin , 1987, Pain.

[86]  P. Eide,et al.  Test-dependent changes in nociception after administration of the putative serotonin antagonist metitepin in mice , 1987, Neuropharmacology.

[87]  S. Hunskaar,et al.  The effect of diazepam on nociception in mice. , 1987, Pharmacology & toxicology.

[88]  R. Mosqueda‐Garcia,et al.  Endorphinergic mechanism in the central cardiovascular and analgesic effects of clonidine. , 1987, Canadian journal of physiology and pharmacology.

[89]  Kjell Hole,et al.  The formalin test in mice: dissociation between inflammatory and non-inflammatory pain , 1987, Pain.

[90]  M. Fanselow,et al.  Quaternary naltrexone reveals the central mediation of conditional opioid analgesia , 1987, Pharmacology Biochemistry and Behavior.

[91]  H. Jørgensen,et al.  Antinociceptive effects of (±)‐, (+)‐ and (‐)‐nefopam in mice , 1987, The Journal of pharmacy and pharmacology.

[92]  S. Hunskaar,et al.  Involvement of central serotogenic pathways in nefopam-induced antiniciception , 1987 .

[93]  M. Inase,et al.  Effects of morphine on two types of nucleus raphe dorsalis neurons in awake cats , 1987, Pain.

[94]  C. Post,et al.  Changes in nociception after acute and chronic administration of zimelidine: Different effects in the formalin test and the substance p behavioural assay , 1987, Neuropharmacology.

[95]  J. Carmody,et al.  Swim stress reduces chronic pain in mice through an opioid mechanism , 1987, Neuroscience Letters.

[96]  S. Hunskaar.  Similar effects of acetylsalicylic acid and morphine on immediate responses to acute noxious stimulation. , 1987, Pharmacology & toxicology.

[97]  R. Mueller,et al.  The antinociceptive effects of prostaglandin antagonists in the rat. , 1987, European journal of pharmacology.

[98]  K. Saito,et al.  Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice. , 1987, Japanese journal of pharmacology.

[99]  S. Hunskaar,et al.  Orphenadrine citrate increases and prolongs the antinociceptive effects of paracetamol in mice. , 2009, Acta pharmacologica et toxicologica.

[100]  K. Franklin,et al.  A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain. , 1986, Life sciences.

[101]  M. Kirby,et al.  Regulatory mechanisms for subtance P in the dorsal horn during a nociceptive stimulus: Axoplasmic transport vs electrical activity , 1986, Brain Research.

[102]  C. Post,et al.  Effects of the putative 5-HT1A receptor agonist 8-OH-2-(di-n-propylamino)tetralin on nociceptive sensitivity in mice , 1986, Pharmacology Biochemistry and Behavior.

[103]  R. Melzack,et al.  Habenular stimulation produces analgesia in the formalin test , 1986, Neuroscience Letters.

[104]  R. Inoki,et al.  [Peripheral analgesic actions of opioid peptides and morphine analogues]. , 1986, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[105]  K. Franklin,et al.  The stress of a novel environment reduces formalin pain: possible role of serotonin. , 1986, European journal of pharmacology.

[106]  K. Hole,et al.  Changes in nociception after 6-hydroxydopamine lesions of descending catecholaminergic pathways in mice , 1986, Pharmacology Biochemistry and Behavior.

[107]  H. Takagi,et al.  Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain , 1986, Neuropharmacology.

[108]  S. Hunskaar,et al.  Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test , 1986, Pain.

[109]  R. Inoki,et al.  [Studies of inflammatory pain response: related pain producing substance and endogenous opioid system]. , 1986, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[110]  S. Jabbur,et al.  Supraspinal modulation of nociception in awake rats by stimulation of the dorsal column nuclei , 1986, Brain Research.

[111]  S. Hunskaar,et al.  Lesions of the ascending serotonergic pathways and antinociceptive effects after systemic administration of p-chloroamphetamine in mice , 1986, Pharmacology Biochemistry and Behavior.

[112]  K. Franklin,et al.  Noncompetitive antagonism of morphine analgesia by diazepam in the formalin test , 1986, Pharmacology Biochemistry and Behavior.

[113]  R. Melzack,et al.  Morphine injected into the habenula and dorsal posteromedial thalamus produces analgesia in the formalin test , 1985, Brain Research.

[114]  K. Hole,et al.  Changes in nociception after lesions of descending serotonergic pathways induced with 5,6-dihydroxytryptamine Different effects in the formalin and tail-flick tests , 1985, Neuropharmacology.

[115]  M. Fanselow,et al.  Exposure to a cat produces opioid analgesia in rats. , 1985, Behavioral neuroscience.

[116]  M. Kirby,et al.  Increase in substance P in the dorsal horn during a chemogenic nociceptive stimulus , 1985, Brain Research.

[117]  S. Hunskaar,et al.  Formalin test in mice, a useful technique for evaluating mild analgesics , 1985, Journal of Neuroscience Methods.

[118]  B. Jacobs,et al.  Response of serotonin-containing neurons in nucleus raphe magnus to morphine, noxious stimuli, and periaqueductal gray stimulation in freely moving cats , 1985, Experimental Neurology.

[119]  M. Fanselow,et al.  Odors released by stressed rats produce opioid analgesia in unstressed rats. , 1985, Behavioral neuroscience.

[120]  S. Maier,et al.  Spinal pain suppression mechanisms may differ for phasic and tonic pain , 1985, Brain Research.

[121]  S. Hunskaar,et al.  Antinociceptive effects of orphenadrine citrate in mice. , 1985, European journal of pharmacology.

[122]  C. Chapman,et al.  Pain measurement: an overview , 1985, Pain.

[123]  G. Kunos,et al.  Naloxone reverses the antinociceptive action of clonidine in spontaneously hypertensive rats , 1985, Brain Research.

[124]  S. Naruse,et al.  [Formalin-induced minor tremor response as an indicator of pain]. , 1984, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[125]  U. Nayar,et al.  The formalin test: A tonic pain model in the primate , 1984, Pain.

[126]  S. Naruse,et al.  A modified formalin test for measuring analgesia in mice , 1984 .

[127]  R. Melzack,et al.  Behavioral evidence in rats for a peptidergic-noradrenergic interaction in cutaneous sensory and vascular function , 1984, Neuroscience Letters.

[128]  R. Melzack,et al.  Unilateral analgesia produced by intraventricular morphine , 1984, Brain Research.

[129]  S. Maier,et al.  The formalin test and the opioid nature of stress-induced analgesia. , 1984, Behavioral and neural biology.

[130]  R. Melzack,et al.  Single nerve capsaicin: Effects on pain and morphine analgesia in the formalin and foot-flick tests , 1984, Brain Research.

[131]  A. Spring.  Der Einfluß des zentralen Höhlengraus der Katze auf Schmerz bei Elektrostimulation im Aquädukt , 1984 .

[132]  M. Fanselow.  Shock-induced analgesia on the formalin test: effects of shock severity, naloxone, hypophysectomy, and associative variables. , 1984, Behavioral neuroscience.

[133]  H. Takagi,et al.  Noxious stimuli and Met-enkephalin release from nucleus reticularis gigantocellularis , 1984, Brain Research Bulletin.

[134]  R. Melzack,et al.  Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests , 1984, Pain.

[135]  H. Takagi.  Experimental pain and neuropeptides. , 1984, Clinical therapeutics.

[136]  R. Melzack,et al.  Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests , 1983, Experimental Neurology.

[137]  M. Zimmermann,et al.  Ethical guidelines for investigations of experimental pain in conscious animals , 1983, Pain.

[138]  M. Kirby,et al.  Morphine blocks the increase in acid phosphatase in the substantia gelatinosa during pain , 1983, Neuroscience Letters.

[139]  R. Melzack,et al.  Morphine analgesia and tolerance in the tail-flick and formalin tests: Dose-response relationships , 1982, Pharmacology Biochemistry and Behavior.

[140]  R. Melzack,et al.  Brainstem lesions dissociate neural mechanisms of morphine analgesia in different kinds of pain , 1982, Brain Research.

[141]  M. Kirby,et al.  Changes in acid phosphatase activity in the substantia gelatinosa in response to pain , 1982, Brain Research.

[142]  R. Melzack,et al.  Morphine analgesia in the tail-flick and Formalin pain tests is mediated by different neural systems , 1982, Experimental Neurology.

[143]  R. Melzack,et al.  Dissociation of the mechanisms of stimulation-produced analgesia (SPA) in tests of tonic and phasic pain , 1981, PAIN.

[144]  R. Melzack,et al.  Apparent lack of tolerance in the formalin test suggests different mechanisms for morphine analgesia in different types of pain , 1981, Pharmacology Biochemistry and Behavior.

[145]  G. Carli,et al.  Effects of pain, morphine and naloxone on the duration of animal hypnosis , 1981, Behavioural Brain Research.

[146]  R. Melzack,et al.  Pain modulation by 5-hydroxytryptaminergic agents and morphine as measured by three pain tests , 1980, Experimental Neurology.

[147]  N. Amodei,et al.  Unilateral knife cuts produce ipsilateral suppression of responsiveness to pain in the formalin test , 1980, Brain Research.

[148]  R. Melzack,et al.  Pain modulation by adrenergic agents and morphine as measured by three pain tests. , 1980, Life sciences.

[149]  D. Moss,et al.  Tonic analgesic effects of Δ9-tetrahydrocannabinol as measured with the formalin test , 1980 .

[150]  C. Almli,et al.  Ontogeny of lateral preoptic unit activity in rats , 1979, Brain Research Bulletin.

[151]  D. Dubuisson,et al.  The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats , 1977, Pain.

[152]  M. North.  Naloxone reversal of morphine analgesia but failure to alter reactivity to pain in the formalin test. , 1978, Life sciences.

[153]  J. K. Wang.  Stimulation-produced analgesia. , 1976, Mayo Clinic proceedings.

[154]  R. Melzack,et al.  Analgesia produced by brain stimulation: evidence of a prolonged onset period. , 1974 .

[155]  P. M. Lish,et al.  Studies on the acute inflammatory response. I. Involvement of the central nervous system in certain models of inflammation. , 1968, The Journal of pharmacology and experimental therapeutics.

[156]  W. Beaver.  Mild analgesics. A review of their clinical pharmacology. II. , 1966, The American journal of the medical sciences.

[157]  Beaver Wt.  Mild analgesics. A review of their clinical pharmacology. , 1965 .

[158]  H. Selye.  Participation of Adrenal Cortex in Pathogenesis of Arthritis , 1949 .

[159]  T. Lewis.  Observations relating to referred pain. Viscecromotor reflexes and other associated phenomena. , 1939 .