Synthesis, characterization and in vitro cytotoxicity of ruthenium(II) metronidazole complexes: Cell cycle arrest at G1/S transition and apoptosis induction in MCF-7 cells.

[1]  A. Brás,et al.  Ruthenium(II)–Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs , 2022, Pharmaceutics.

[2]  J. Kusz,et al.  Multifunctional Silver(I) Complexes with Metronidazole Drug Reveal Antimicrobial Properties and Antitumor Activity against Human Hepatoma and Colorectal Adenocarcinoma Cells , 2022, Cancers.

[3]  M. Ionta,et al.  Ruthenium(II) complex containing cinnamic acid derivative inhibits cell cycle progression at G0/G1 and induces apoptosis in melanoma cells , 2022, New Journal of Chemistry.

[4]  Colin G. Cameron,et al.  It Takes Three to Tango - the length of the oligothiophene determines the nature of the long-lived excited state and the resulting photocytotoxicity of a Ru(II) photodrug. , 2021, ChemPhotoChem.

[5]  C. Kim,et al.  Ruthenium Complexes as Anticancer Agents: A Brief History and Perspectives , 2020, Drug design, development and therapy.

[6]  S. Jana,et al.  Analysis of Isotopic Abundance Ratio of Consciousness Energy Healing Treated Metronidazole Using LC-MS and GC-MS Spectrometry , 2020 .

[7]  A. Ozarowski,et al.  Structural, spectroscopic insights, and antimicrobial properties of mononuclear and dinuclear metal(II) carboxylate derivatives with metronidazole , 2020 .

[8]  D. Bellnier,et al.  TLD1433-Mediated Photodynamic Therapy with an Optical Surface Applicator in the Treatment of Lung Cancer Cells In Vitro , 2020, Pharmaceuticals.

[9]  R. Viana,et al.  Novel ruthenium(II) complexes with cimetidine: DFT calculations and in vitro cytotoxic activities against glioblastoma cell lines , 2020, Inorganica Chimica Acta.

[10]  R. C. Gonçalves,et al.  Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities. , 2020, Journal of inorganic biochemistry.

[11]  L. Radko,et al.  Silver(I) Complexes of the Pharmaceutical Agents Metronidazole and 4-Hydroxymethylpyridine: Comparison of Cytotoxic Profile for Potential Clinical Application , 2019, Molecules.

[12]  B. James,et al.  Syntheses of new ruthenium (II and III)-nitroimidazole complexes , 2019, Inorganica Chimica Acta.

[13]  F. Jia,et al.  Recent Developments in the Interactions of Classic Intercalated Ruthenium Compounds: [Ru(bpy)2dppz]2+ and [Ru(phen)2dppz]2+ with a DNA Molecule , 2019, Molecules.

[14]  L. C. Romero-Quezada,et al.  Therapeutic uses of metronidazole and its side effects: an update. , 2019, European review for medical and pharmacological sciences.

[15]  Huaben Bo,et al.  Applications of Ruthenium Complex in Tumor Diagnosis and Therapy , 2018, Front. Pharmacol..

[16]  Guilherme A. Ferreira-Silva,et al.  Pro-apoptotic activity of ruthenium 1-methylimidazole complex on non-small cell lung cancer. , 2018, Journal of inorganic biochemistry.

[17]  A. Batista,et al.  Phosphine/diimine ruthenium complexes with Cl−, CO, NO+, NO2−, NO3− and pyridine ligands: Pro-apoptotic activity on triple-negative breast cancer cells and DNA/HSA interactions , 2018 .

[18]  E. Barreiro,et al.  Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics? , 2018, Journal of medicinal chemistry.

[19]  N. Hunter,et al.  Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms. , 2018, The Journal of antimicrobial chemotherapy.

[20]  J. Ellena,et al.  Polypyridyl Ruthenium Complexes: Novel DNA-Intercalating Agents against Human Breast Tumor , 2017 .

[21]  Guilherme A. Ferreira-Silva,et al.  [Ru(pipe)(dppb)(bipy)]PF6: A novel ruthenium complex that effectively inhibits ERK activation and cyclin D1 expression in A549 cells. , 2017, Toxicology in vitro : an international journal published in association with BIBRA.

[22]  B. Patrick,et al.  Ruthenium(III and II) β-diketonate complexes containing imidazoles , 2017 .

[23]  M. Cooper,et al.  Nitroimidazoles: Molecular Fireworks That Combat a Broad Spectrum of Infectious Diseases. , 2017, Journal of medicinal chemistry.

[24]  F. Bhat.  ORGANOMETALLIC COMPOUNDS OF RUTHENIUM AND THEIR ANTI-CANCER PROPERTIES , 2017 .

[25]  S. Halder,et al.  A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition , 2016, Scientific Reports.

[26]  Lanmei Chen,et al.  The studies on the cytotoxicity in vitro, cellular uptake, cell cycle arrest and apoptosis-inducing properties of ruthenium methylimidazole complex [Ru(MeIm)4(p-cpip)](2.). , 2016, Journal of inorganic biochemistry.

[27]  Jian-hua Zhao,et al.  Effect of radiation on cytotoxicity, apoptosis and cell cycle arrest of human osteosarcoma MG-63 induced by a ruthenium(II) complex. , 2015, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

[28]  A. V. Netto,et al.  Antitumour Complexes and DNA Interactions and their Tools of Analysis: an Approach to Metalointercalators , 2015 .

[29]  V. Moreno,et al.  Cytoxicity and Apoptotic Mechanism of Ruthenium(II) Amino Acid Complexes in Sarcoma-180 Tumor Cells , 2014, PloS one.

[30]  T. Govender,et al.  Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands. , 2013, European journal of medicinal chemistry.

[31]  Nicolas P E Barry,et al.  Exploration of the medical periodic table: towards new targets. , 2013, Chemical communications.

[32]  S. Shiva.  Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function☆ , 2013, Redox biology.

[33]  E. Silveira-Lacerda,et al.  Induction of Cell Cycle Arrest and Apoptosis by Ruthenium Complex cis-(Dichloro)tetramineruthenium(III) Chloride in Human Lung Carcinoma Cells A549 , 2011, Biological Trace Element Research.

[34]  Kai Liu,et al.  Nitroimidazoles as anti-tumor agents. , 2011, Anti-cancer agents in medicinal chemistry.

[35]  A. Nagarjuna,et al.  DNA–interactions of ruthenium(II) & cobalt(III) phenanthroline and bipyridine complexes with a planar aromatic ligand 2-(2-fluronyl)1H-imidazo[4,5-f][1,10-Phenanthroline] , 2011 .

[36]  E. Antonarakis,et al.  Ruthenium-based chemotherapeutics: are they ready for prime time? , 2010, Cancer Chemotherapy and Pharmacology.

[37]  C. Gomes,et al.  Nitroimidazoles - a promising class of compounds for the treatment of Tuberculosis , 2010 .

[38]  W. Berger,et al.  KP1019, A New Redox‐Active Anticancer Agent – Preclinical Development and Results of a Clinical Phase I Study in Tumor Patients , 2008, Chemistry & biodiversity.

[39]  Antonio G. Ferreira,et al.  Sobre uma degenerescência acidental nos deslocamentos químicos de RMN de 31P{¹H} em complexos difosfínicos de rutênio , 2008 .

[40]  B. Patrick,et al.  Ruthenium(III) maltolato-nitroimidazole complexes: synthesis and biological activity. , 2006, Journal of Inorganic Biochemistry.

[41]  V. Brabec,et al.  DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity. , 2006, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[42]  S. Agarwal,et al.  Synthesis and Anti‐Amoebic Activity of Gold(I), Ruthenium(II), and Copper(II) Complexes of Metronidazole , 2005, Chemistry & biodiversity.

[43]  A. Adjei,et al.  Targeting Apoptosis Pathways in Cancer Therapy , 2005, CA: a cancer journal for clinicians.

[44]  J. G. Haasnoot,et al.  Synthesis and chemical-pharmacological characterization of the antimetastatic NAMI-A-type Ru(III) complexes (Hdmtp)[trans-RuCl4(dmso-S)(dmtp)], (Na)[trans-RuCl4(dmso-S)(dmtp)], and [mer-RuCl3(H2O)(dmso-S)(dmtp)] (dmtp = 5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidine). , 2004, Journal of Medicinal Chemistry.

[45]  B. Patrick,et al.  Ruthenium(II) sulfoxide-maltolato and -nitroimidazole complexes: synthesis and MTT assay. , 2003, Inorganic chemistry.

[46]  S. Piscitelli,et al.  Clinical Pharmacokinetics of Metronidazole and Other Nitroimidazole Anti-Infectives , 1992, Clinical pharmacokinetics.

[47]  N. Farrell,et al.  A new ruthenium radiosensitizer: RuCl2(DMSO)2(4-nitroimidazole)2. , 1986, International journal of radiation oncology, biology, physics.

[48]  Y. Chien,et al.  Interaction of metronidazole with metallic ions of biological importance. , 1975, Journal of pharmaceutical sciences.

[49]  W. Geary.  The use of conductivity measurements in organic solvents for the characterisation of coordination compounds , 1971 .

[50]  M. Waring,et al.  Complex formation between ethidium bromide and nucleic acids. , 1965, Journal of molecular biology.