Identification and classification of commercially relevant per‐ and poly‐fluoroalkyl substances (PFAS)

Per‐ and poly‐fluoroalkyl substances (PFAS) are a universe of fluorinated organic substances with very different physical, chemical, and biological properties including polymers and non‐polymers; solids, liquids, and gases. Commercial PFAS‐based products have been used in a wide variety of industrial and consumer applications because they have unique performance properties of significant socioeconomic value. The PFAS definition has evolved and expanded over the years. Numerous lists of PFAS, some with thousands of entries, have been compiled, but none have clearly identified which of the substances are commercially relevant. This study is the first to use a bona‐fide “bottom up” approach to identify how many of the 4730 PFAS substances listed in a 2018 OECD/UNEP Report are directly connected to commercial products based on input from three major global producers. This study provides new and valuable insight into the 2018 OECD/UNEP Report list of PFAS substances. The results show that 256, less than 6%, of the 4730 PFAS substances presented in the 2018 OECD/UNEP Report are commercially relevant globally. This study suggests that grouping and categorizing PFAS using fundamental classification criteria based on composition and structure can be used to identify appropriate groups of PFAS substances for risk assessment, thereby dispelling assertions that there are too many PFAS chemistries to conduct proper regulatory risk assessments for the commercially relevant substances. Integr Environ Assess Manag 2021;17:1045–1055. © 2021 The Chemours Company, Beach Edge Consulting, LLC, AGC Chemicals Americas Inc., Daikin America Inc. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

[1]  Carla A. Ng,et al.  An overview of the uses of per- and polyfluoroalkyl substances (PFAS). , 2020, Environmental science. Processes & impacts.

[2]  Zhanyun Wang,et al.  Strategies for grouping per- and polyfluoroalkyl substances (PFAS) to protect human and environmental health. , 2020, Environmental science. Processes & impacts.

[3]  Mark S. Johnson,et al.  Estimating Environmental Hazard and Risks from Exposure to Per‐ and Polyfluoroalkyl Substances (PFASs): Outcome of a SETAC Focused Topic Meeting , 2020, Environmental toxicology and chemistry.

[4]  Zhanyun Wang,et al.  Per- and polyfluoroalkylether substances: identity, production and use , 2020 .

[5]  L. Rudnick.  Synthetics, Mineral Oils, and Bio-Based Lubricants , 2020 .

[6]  Zhanyun Wang,et al.  The concept of essential use for determining when uses of PFASs can be phased out. , 2019, Environmental science. Processes & impacts.

[7]  A. Luz,et al.  Perfluorohexanoic acid toxicity, part I: Development of a chronic human health toxicity value for use in risk assessment , 2019, Regulatory toxicology and pharmacology : RTP.

[8]  A. Luz,et al.  Perfluorohexanoic acid toxicity, part II: Application of human health toxicity value for risk characterization , 2019, Regulatory toxicology and pharmacology : RTP.

[9]  J. Burkholder,et al.  Global warming potential estimates for the C 1 –C 3 hydrochlorofluorocarbons (HCFCs) included in the Kigali Amendment to the Montreal Protocol , 2018 .

[10]  Joseph P. Carlin,et al.  A critical review of the application of polymer of low concern and regulatory criteria to fluoropolymers , 2018, Integrated environmental assessment and management.

[11]  Antony J. Williams,et al.  The CompTox Chemistry Dashboard: a community data resource for environmental chemistry , 2017, Journal of Cheminformatics.

[12]  R. Buck.  Toxicology Data for Alternative “Short-Chain” Fluorinated Substances , 2015 .

[13]  Hong Liu,et al.  Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001-2011). , 2014, Chemical reviews.

[14]  Jinxia Liu,et al.  Microbial degradation of polyfluoroalkyl chemicals in the environment: a review. , 2013, Environment international.

[15]  Konrad Hungerbühler,et al.  Fluorinated alternatives to long-chain perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkane sulfonic acids (PFSAs) and their potential precursors. , 2013, Environment international.

[16]  Sina Ebnesajjad,et al.  Introduction to Fluoropolymers: Materials, Technology and Applications , 2013 .

[17]  Stockholm Convention Secretariat.  Practices In The Sound Management Of Chemicals , 2012 .

[18]  Leslie R. Rudnick,et al.  Synthetics, Mineral Oils, and Bio-Based Lubricants : Chemistry and Technology , 2005 .

[19]  R. Grundmann.  The Montreal protocol , 2003 .

[20]  D. Paustenbach.  Human and Ecological Risk Assessment: Theory and Practice , 2003 .

[21]  C. M. Berrevoets,et al.  Rijksinstituut voor Kust en Zee/RIKZ , 2003 .

[22]  Pim de Voogt,et al.  Environmental and toxicity effects of perfluoroalkylated substances. , 2003, Reviews of environmental contamination and toxicology.

[23]  B. Smart,et al.  Organofluorine chemistry : principles and commercial applications , 1994 .